Grape Seed Extract

SandiaBuddy
SandiaBuddy Member Posts: 1,381 Member
in Colorectal Cancer #1

Does anyone have any thoughts or knowledge about Grape Seed Extract and its effect on colorectal cancer?  There appear to be some initially encouraging test tube studies, but I do not see anything about humans.  Maybe someone else has completed this research or has personal experience?

Here is some of what I found:

Promising: https://www.ncbi.nlm.nih.gov/pubmed/25280404
Test tube: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977641/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217504/
Mice: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710656/
Generic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248468/
Preventative, test tube: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728696/

Thanks for your help.

 

 

 

 

Comments

  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #2
    ltd data

    I'm favorable to combined flavonoids as an essential set of ingredients to make our 5FU cocktail work, e.g. "sensitization", based on actual chemo activity levels for presence vs absence of GSE.  Also GSE has some documentation for clot prevention, like in embolisms - a consideration for a disease where hypercoagulability can be associated with either the disease or the treatments.  

    We've used  GSE at 200-500 mg when on protocol.  N=1

  • mozart13
    mozart13 Member Posts: 118
    edited June 2017 #3
    Grape seed extract

    I've tried before start of folfox treatments, took about 4 or 5 doses, high concentration, felt like taking chemo therapy after few doses, stopped it at that point, dessicion was made that I will skip surgery and go for folfox, so I prepared myself for chemo, had couple of weeks between grape seed extract and chemo, grape seeds  definetlly felt like chemo.

    Here is interesting link:

    <Content edited by CSN Support Team>

  • SandiaBuddy
    SandiaBuddy Member Posts: 1,381 Member
    #4
    Not with oxiliplatin

    Here's an interesting article I came accross that says Grape Seed Extract may help 5-Fu work better, but may decrease the effect of oxiliplatin.   So it seems it would be a good idea to avoid GSE if you are on oxiliplatin:

    http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&amp;page=article&amp;op=view&amp;path[]=15139&amp;path[]=48423

     

     

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