anyone with B-RAF mutation CRC? Seeking alternative cures..

Hello

I a sorry to hear about your sister's diagnosis and continued tries with chemo regimes. 

I personally can't help you with any advice concerning the oils and mushrooms. I hope soon, someone will pop by who can help you. 

Although my stage is IV, I'm blessed to only have had one met, and so far, it has stayed as such. 

During my treatment, I uesed guided imagery, meitation, music to heal. I should have used foods and essential oils, but I didn't. 

There are so many avenues, not all medical. 

I wish your sister well. 

Here's hoping someone posts which can help. You are a loving sibling to visit here looking for ways to help your sister survive. 

Tru

Has she tried a new treatment

called Vemurafenib?

MyJourneywithCancer said:

Or Dabrafenib plus Trametinib?
Sorry for being late. FOLFOX failed and almost killed my wife (54), diagnosed with an aggressive metastatic disease spread to liver, lungs, lymph nodes, and kidney, with unknown primary. Her liver biopsy showed BRAF V600E (hope that’s what you meant), and she has excellent response to BRAF plus MEK inhibitor (combo is known to reduce drug resistance) for 6 months and counting. Side effects are almost non-existent.

Or Dabrafenib plus Trametinib?

I have a BRAF V600E mutation from liver biopsy (primary on pancreas) and have been taking Dabrafenib and Trmetinib for 10 months. Had excellent shrinkage at first but it has slowed down. And now there is a new unknown growth that I had biopsied--still waiting for results. How is your wife doing now?

NHMike said:

For those wondering about

For those wondering about BRAF (I read this thread and it was scary), BRAF testing looks like it's covered by ImmunoHistoChemistry testing as well as MicroSatelliteInstability testing and anyone with Colon Cancer should have at least had the first test done. Their oncologist should have ordered the IHC test; the MSI test is a genetic test and it isn't necessarily done as I believe that it's more expensive and that the IHC test almost entirely covers four variant genes. I believe that the MSI test covers five genes (my son told me this yesterday). I believe that both tests cover 92% of the overall bad genes but not the same 92%.

For those wondering about

Why is it scary? What's more scary than cancer?

linnythepoo said:

Or Dabrafenib plus Trametinib?

I have a BRAF V600E mutation from liver biopsy (primary on pancreas) and have been taking Dabrafenib and Trmetinib for 10 months. Had excellent shrinkage at first but it has slowed down. And now there is a new unknown growth that I had biopsied--still waiting for results. How is your wife doing now?

Hello Linnythepoo
Good to hear that your disease responded for 10 months, and your onco team is proactive in doing new biopsy on progression. Hopefully this will lead to new clue(s) as to how the drug resistance occurred, and identification of at least one new drugable target. Make sure they are doing another genomic profiling from the new biopsy sample to follow the tumor evolution. Secondly, microsatellite status should be included in the diagnostics, so be PD-L1 quantitation, in anticipation of possible immunotherapy. Thirdly, recent publications from Dr. Neyns' and other groups showed BRAFi+MEKi re-challenge is also an viable option with intervening drug 'holiday'.
As for my wife, her liver enzymes started to show some upward trending, but her latest scan about a month ago showed a stable condition, and she is feeling excellent.
Please keep in touch.
Wish you all the best.

Something called Encorafenib is in early trial phase:

www.cancerdiscovery.aacrjournals.org/content/7/6/610

or

www.medicalxpress.com/print415898642.html      on vemurafenib.

There's also something called PLX8394