Poorly differeniate diffuse signet ring cells

Hi Ellen
CDH1 is a genetic
Hi Ellen
CDH1 is a genetic mutation that is known to cause Hereditary Diffuse Gastric cancer. However, HDGC has been known to run in families that do not carry the CDH1 mutation. This is very rare and represents only a fraction of stomach cancers. Any family that finds clusters of gastric cancer, particularly early onset (age 50 or under) should become informed about CDH1 and HDGC.
As far as it being aggressive, that's not how I would describe it at all. More like "sneaky." This cancer does not form large tumors, rather the cells are scattered and often hiding in the stomach lining. Because of this, it is very hard to detect until it has spread. I would refer you to the website
Bestronghearted.org
There you will find lots of information and links to even more information about this condition.

I have the same cancer type - treated with 5FU, then oxaliplatin

I also have "poorly differentiated" and "diffuse signet cell type" adenocarcinoma. I had most of my stomach removed, followed by 5FU chemotherapy plus radiation. After that ended, my oncologist started me on the "XELOX" regimen (Xeloda plus oxaliplatin). I was wondering if anybody else received this treatment, or has any experience with it. 

I 2 have "poorly differentiated" and "diffuse" signet cell type

I also have "poorly differentiated" and "diffuse signet cell type" gastric adenocarcinoma. I was diagnosed on April 13 and was fully staged (4) by May 10, the date of my first EOX chemo treatment--3 cycles, then will re-stage. I am in the Bay Area, treated at Alta Bates and consulting at Stanford. I am looking into possibly HIPEC (CA options for HIPEC include City of Hope in L.A. and UCSD). Scared but taking it day-by-day. I welcome input! 

Sima said:

I have the same cancer type - treated with 5FU, then oxaliplatin

I also have "poorly differentiated" and "diffuse signet cell type" adenocarcinoma. I had most of my stomach removed, followed by 5FU chemotherapy plus radiation. After that ended, my oncologist started me on the "XELOX" regimen (Xeloda plus oxaliplatin). I was wondering if anybody else received this treatment, or has any experience with it. 

POORLY DIFFERENTIATED

Hello Sima,

My husband was diagnosed with the same as you in the first week of April 2017. He had first chemo on apr 26 and second on may 16. His treatment is ECX every 3 weeks. He is on Xeolda from the beginning.  He is 53. He did not have any side effects other than hair loss.  How are you doing?  I am very emotional. I have 3 young kid. I hope you are feeling better.

Looking for direction

My sister has been diagnosed with stage IV, signet cell adenocarcinoma of the stomach and we are desperate to find a hospital, cancer center, or doctor that is familiar with kind of cancer. Also what kind of chemo and treatments have others received that can slow this runaway train down. Any and all help is appreciate.

Thank you

Peggy

Signet ring gastric cancer

Hello: Am new to this forum. My husband was diagnosed with stage 4 signet ring carcinoma in October of 2015. Surgeon diagnosed it as colon cancer, and did a hemicolectomy excising hopefully all of the cancer in the colon. Biopsy showed it to be poorly differentiated. Then in August of 2017, he was having some belching, so a gastroenterologist did a scope on him and did a biopsy of some tissue. The diagnosis was changed to gastric cancer. The doctor said his type of cancer grows very flat, so technically it has never "shown" on any of his PET scans and CT scans. We have used two different oncologists as we were not happy with either one - just providing little knowledge and a reluctance to fully answer questions - extremely frustrating. Both oncologists had to have known that gastric cancer often grows flat, so they should not have told my husband that he was in remission. His chemo was cut back, then the stomach scope of August 2017, which changed the doctor's mind on remission. Twice, his doctor has told him that he is surprised my husband has lasted this long - that is really not a compliment and a patient does not need to hear this, for pete's sake. Could write volumes on the insensitivity of many physicians. My husband's doctor believes in systemic chemo and has been totally resistant to immunotherapy. Finally, he tested my husband and found him PDL1-negative, which means he is not a candidate for immunotherapy. The doctor also seems very reluctant to Hipec surgery and cannot really give a reason that I can comprehend. My husband is presently on Taxol and Cyramza as the other chemo finally gave too many side effects. Again, the cancer has not shown on any PET or CT scans, so we wonder how bad can it be? He feels pretty good except for tiredness. I know it seems like the thing to do would be to change doctors, but since we have changed already, my husband is reluctant to change again and doesn't want to spend a lot of time at a hospital like M.D. Anderson. If it was up to me, I'd move on to a third oncologist. Any advice from any of you fine people on anything I have written - would be much appreciated.