Staging uterine Carcinoma

Staging uterine carcinoma - UpToDate 3/17/17, 10:06 AM

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Staging uterine carcinoma* (TNM and International Federation of

Gynecology and Obstetrics [FIGO])

Primary tumor (T) (surgical-pathologic findings)

TNM

categories

FIGO

stages

Definition

TX Primary tumor cannot be assessed

T0 No evidence of primary tumor

Tis Carcinoma in situ (preinvasive carcinoma)

T1 I Tumor confined to corpus uteri

T1a IA Tumor limited to endometrium or invades less than one-half of the myometrium

T1b IB Tumor invades one-half or more of the myometrium

T2 II Tumor invades stromal connective tissue of the cervix but does not extend

beyond uterus

T3a IIIA Tumor involves serosa and/or adnexa (direct extension or metastasis)

T3b IIIB Vaginal involvement (direct extension or metastasis) or parametrial

involvement

T4 IVA Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not

sufficient to classify a tumor as T4)

Regional lymph nodes (N)

TNM

categories

FIGO

stages

Definition

NX Regional lymph nodes cannot be assessed

N0 No regional lymph node metastasis

N1 IIIC1 Regional lymph node metastasis to pelvic lymph nodes

N2 IIIC2 Regional lymph node metastasis to para-aortic lymph nodes, with or without

positive pelvic lymph nodes

Distant metastasis (M)

TNM

categories

FIGO

stages

Definition

M0 No distant metastasis

¶

Δ

Staging uterine carcinoma - UpToDate 3/17/17, 10:06 AM

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M1 IVB Distant metastasis (includes metastasis to inguinal lymph nodes intraperitoneal

disease, or lung, liver, or bone. It excludes metastasis to para-aortic lymph

nodes, vagina, pelvic serosa, or adnexa.)

Anatomic stage/prognostic groups

Carcinomas*

Stage 0 Tis N0 M0

Stage I T1 N0 M0

Stage IA T1a N0 M0

Stage IB T1b N0 M0

Stage II T2 N0 M0

Stage III T3 N0 M0

Stage IIIA T3a N0 M0

Stage IIIB T3b N0 M0

Stage IIIC1 T1-T3 N1 M0

Stage IIIC2 T1-T3 N2 M0

Stage IVA T4 Any N M0

Stage IVB Any T Any N M1

NOTE: cTNM is the clinical classification, pTNM is the pathologic classification.

* Carcinosarcomas should be staged as carcinoma.

¶ FIGO no longer includes Stage 0 (Tis).

Δ Endocervical glandular involvement only should be considered as Stage I and not as Stage II.

Used with the permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original

source for this material is the AJCC Cancer Staging Manual, Seventh Edition (2010) published by Springer

New York, Inc.

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