Nexavar Sorafenib questions please help
I need to know how good is Nexavar (Sorafenib) at targeting RAF1 mutation, I ask this because Mom used Foundation One, have this mutation, and one of three Targeted Therapies recommended is Sorafenib, the other two being Regorafenib and Trametinib
The mutation is related to cell division pathway called the MAPK path: MAPK>RAS>RAF>MEK>CCNE1
Also, how to avoid as much as we can nausea? and if you can tell the most frequent side effects in practise and ways to avoid them
Primary cancer is unknown mucinous adenocarcinoma but Sorafenib is recommended, people use it on this forum, and there are five liver metastases, that's why the question here
Many thanks in advance for any help
Comments
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Nexavar Use
I was on Nexavar for about 10 months out of 14 months. Started out on 400mg/day and worked up to 600mg/day. The following is an excerpt from an email I sent to my doctors regarding how I felt taking Nexavar.
"The fatigue is absolutely crushing, I have digestive tract issues every other day, my ability to focus and concentrate is impaired, my appetite has dropped, I am physically weak, my energy level is extremely low and my attitude is poor. I would put my quality of life at 50% of what it normally is. I have had to cancel business trips as I do not have the energy or strength to travel as I should. My enjoyment of my personal life has been significantly reduced due to my fatigue, energy level and poor attitude."
The benefit was questionable so I opted to discontinued taking it. Two TACE procedures have shrunk the HCC tumors I had and now the docs are deciding if I should have an RFA or Y-90 treatment on the remaining tumor mass. The docs supported my decision, although I would have decided the same whether they agreed or not. It becomes a personal choice. Good luck.
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