My Recent Pathology Report
I have been reading lots of your posts and some links from them and I thank all of you for these.
I got dianosed with PCa 2 yrs ago 7/2013 at age 56 after going on HRT where my PSA spiked from 3.8 to 5.3 within 30 days.
I had the 12 blind biopsy with 1 core having 1% adenocarcinoma. GS was 3+3
I went on Active Servelence with first year having an MRI with Gadolinium contrast and Transrectal Ultrasound. Nothing alarming except I had aquired a bad rash all over my body, numb right arm for 3 months, and a very bad case of dandruff. Needless to say I could not do this again so I studied about my PCa for another year.
I had also been seeing a Naturopathic doctor that really knows how cancer works and we were able to correct all of my NK cells and cytokines levels except IL-12.
I became alarmed with several recent NIH research papers that showed if I had certain gene mutations (NOS3) which I most certainly did (thanks to 23andme for providing this service) I had 6.3 times chance of my PCa progressing.
The -786T>C promoter polymorphism of the NOS3 gene is associated with prostate cancer progression.
Another recent NIH paper showed I had 1.6 times chance of having aggressive prostate cancer.
TT genotype of SNP rs4054823 at 17p12 Inherited genetic variant predisposes to aggressive but not indolent prostate cancer (PMCID2836698)
Also my 23andme results showed I had a 5.3 times chance of developing PCa based on several gene mutations. How true.
So I sent these research papers to my Doctor (Libertino) and presented this to him and he agreed to take out my prostate via open surgery as he is better at this method and he can be more accurate if he had to take some of the nerve bundls out. As it was he said he had removed 50% from each nerve bundle.
It was a good thing, but it may have been to late.
Here is my Pathology Report
Adenocarcinoma of Prostate with Bi-Lateral Extension into Extraprostatic soft tissue.
Tumor Site - Bilateral, mostly in peripheral zone
Weight 63 grams Size 3.5x4x3.5 cm
Gleason score - 3 +4
Terttiary Pattern - Not PResent
Severity and Extent of Tumor: 3/5 (3 being 15 - 30-%)
No Lymph Nodes were biopsied
TNM Stage pT3a, pNX, pMX
Lymphatic (small vessel) invasion: Not Seen
PNI is present
No Tumor seen in Seminal Vesel
Margin status: Positive Inked margins: Right and Left Peripheral Prostate, Focaly Transected
Positive shaved margine - NO
Other Margins are Clear.
I am not sure what I can do at this time, but wait for my 8 weeks for my PSA and hope.
I am moving my treatment to Mass General and am confident in them. I am also worried about radiation and Hormone Ablation Therapy.
I have been reading about some new immunotherapies like CAR T cell and I really need to not worry and just wait for my PSA in 2 weeks.
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