Maybe Cyramza(ramucirumab) will be of help for some of you here:

janderson1964 said:

Info i could find looks

Info i could find looks promising however isnt this what Zaltrap was supposed to be which wasnt any brtter than avastin with a cost so hogh that MSK wouldnt even use it. I hope i am wrong. We are desperate for new options.

has approved only Zaltrap and Regorafenib. I've read of many others that failed or are still in clinical phases,from every part of the world. If you want, i'll toss out a bunch of stuff i've come across if anyone wants to do some further research.....(D4476 with an antimalarial,chlorquine; adding vemurafenib to BRAF-mutatant treatment;MEK162 plus FOLFOX being most recent)

coloCan said:

a little more on FDA's approval

http://ecancer.org/news/7245-fda-approves-ramucirumab-for-mketatastic-colorectal-cancer.php

Hopefully this will prove effecive to many who could use it

(TAS-102 still to be heard from in US)

prnewswire.com on 4/23 had an item about a CRC vaccine being worked on by DanDrit Biotech and Riyadh Pharma

And here's a link to trial for Xilonix

http://xcitecolontrial.com/clinical-qualifier-questionnaire/

www.newswise.com/articles/camptothecin-analog-fl118-can-overcome-treatment-resistance-outperform-approved-therapies

janderson1964 said:

All you posts and information

All you posts and information is very helpful. I really appreciate it and read all of the links that you post.