Grade and KI67 ratings

vickiek811
vickiek811 Member Posts: 20
in Breast Cancer #1

I'm curious....how much value do oncologists place on the grade and KI67 score when deciding treatmwnt?  My grade was considered 3+ and my Ki67 was 38% and "unfavorable."  I was told as soon as the stage is known (mine is 2A) that that is what doctors really rely on.  What does the "unfavorable" mean on the Ki67 rating?  I heard it's how effective it will respond to treatment.  I talked with the doctor about it at my first appointment, but it was answered in a round about way that didn't really answer it at all.  Thanks!

Comments

  • so-she-did
    so-she-did Member Posts: 2
    #2
    My Ki-67 score was 50%.  This

    My Ki-67 score was 50%.  This means that about 50% of my cells that they viewed under the microscope were in the process of reproducing to make new cells (called mitosis).  This helps determine how fast the tumor is growing.  My path report states, "Patients who overexpress Ki-67 in more than 50% of the cells are at high risk of developing recurrent disease" - which is why I may undergo chemo even if my lymph biopsy is negaitve - it will be up to my medical oncologist.  I have consulted with 2 surgeons and the first surgeon was more concerned about the score than the 2nd. Both of the surgeons I have seen have said that they are basically building a story of my tumor and all the information together determines treatment, not one thing alone.  I know that I haven't answered all of your question (I am a newby myself and don't know the whole answer), but I hope I cleared up the Ki-67 for you. 

     

    Invasive ductal carcinoma with some lobular features, grade 2.  ER+, PR+, HER2-.  Lumpectomy and lymph node biopsy scheduled for Jan. 15.

  • happydyad
    happydyad Member Posts: 1
    #3
    so-she-did said:

    My Ki-67 score was 50%.  This

    My Ki-67 score was 50%.  This means that about 50% of my cells that they viewed under the microscope were in the process of reproducing to make new cells (called mitosis).  This helps determine how fast the tumor is growing.  My path report states, "Patients who overexpress Ki-67 in more than 50% of the cells are at high risk of developing recurrent disease" - which is why I may undergo chemo even if my lymph biopsy is negaitve - it will be up to my medical oncologist.  I have consulted with 2 surgeons and the first surgeon was more concerned about the score than the 2nd. Both of the surgeons I have seen have said that they are basically building a story of my tumor and all the information together determines treatment, not one thing alone.  I know that I haven't answered all of your question (I am a newby myself and don't know the whole answer), but I hope I cleared up the Ki-67 for you. 

     

    Invasive ductal carcinoma with some lobular features, grade 2.  ER+, PR+, HER2-.  Lumpectomy and lymph node biopsy scheduled for Jan. 15.

    Thinking of You, so-she-did! Tomorrow's the day!

    I noticed that your lumpectomy is tomorrow and will be keeping you in my prayers.  You will do great!  Ki-67 indicates the likelihood of the cancer to migrate to another area of your body. I did a mastectomy so skipped any radiation but since you are having lumpectomy you will likely be following that up with 6 weeks or more of radiation and possibly with chemo too.  Stay brave.  Stay strong.  This too will pass!  Big hug, Judy

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