kras mutation

kennyt
kennyt Member Posts: 110
in Colorectal Cancer #1

I found out today I have the kras mutation is that a really bad thing?

Comments

  • jen2012
    jen2012 Member Posts: 1,607 Member
    #2
    not bad
    Kenny...I think that just tells the docs that some types of chemo will not be of benefit to you. Good to know so they can try something that will work!
  • LivinginNH
    LivinginNH Member Posts: 1,456 Member
    #3
    Erbitux

     

    The drug Cetuximab (Erbitux) will not work for KRAS mutant type individuals.  If you were KRAS wild-type, it would most likely be given after Folfox/Folfuri is no longer working to suppress the cancer cells.

    "Cetuximab is indicated for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing, KRAS wild-type metastatic colorectal cancer (mCRC), in combination with chemotherapy, and as a single agent in patients who have failed oxaliplatin- and irinotecan-based therapy and who are intolerant to irinotecan."

    Take care,

    Cyn

  • thxmiker
    thxmiker Member Posts: 1,278 Member
    #4
    KRAS means that some Chemos

    KRAS means that some Chemos are  not going to be effective.  (Luckily some of the most destructive to the body chemos are not going to be administered!)  I would go to a real professional like Lenz @ USC, UCSD, Sugerbaker in DC, etc...

     

    Best Always,  mike

  • herdizziness
    herdizziness Member Posts: 3,624 Member
    #5
    No Kenny not a really bad thing

    It just means that certain chemo's won't do  you much good. For instance being Kras Wild, will give you more availability to other chemo's.  But it is good to know you won't waste your time and body on chemo's that won't work, in your case for instance Erbitux being one of them, it saves you from going to things that won't work well by the knowledge of what you are, in your case Kras Mutant.  Don't feel alone, many are Kras mutant.

    Winter Marie

  • coloCan
    coloCan Member Posts: 1,944 Member
    #6
    herdizziness said:

    No Kenny not a really bad thing

    It just means that certain chemo's won't do  you much good. For instance being Kras Wild, will give you more availability to other chemo's.  But it is good to know you won't waste your time and body on chemo's that won't work, in your case for instance Erbitux being one of them, it saves you from going to things that won't work well by the knowledge of what you are, in your case Kras Mutant.  Don't feel alone, many are Kras mutant.

    Winter Marie

    vectibix(panitumumab) is also not recommended for those

    with a KRAS mutation; it is like Erbitux (Cetuximab)in that both target EGFR

  • renw
    renw Member Posts: 282 Member
    #7
    Statistically, your long term

    Statistically, your long term survival is lower as a kras mutant, but still better to have kras than braf.

  • kennyt
    kennyt Member Posts: 110
    #8
    renw said:

    Statistically, your long term

    Statistically, your long term survival is lower as a kras mutant, but still better to have kras than braf.

    I'm planning on beating the

    I'm planning on beating the stats anyhow

  • jen2012
    jen2012 Member Posts: 1,607 Member
    #9
    kennyt said:

    I'm planning on beating the

    I'm planning on beating the stats anyhow

    Good plan Kenny!
    Good plan Kenny!
  • MaryCarol5
    MaryCarol5 Member Posts: 102
    #10
    kennyt said:

    I'm planning on beating the

    I'm planning on beating the stats anyhow

    Love that!

    Love that!

  • fatbob2010
    fatbob2010 Member Posts: 467 Member
    #11
    Good Plan

    Kenny...love your attitude...keep it up!!

    Art

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