Renal Vein Invasion

Texas_wedge said:

suspected gall bladder

For the purposes of my database building,  I'd be grateful if you could put me in touch with everyone you know who has chRCC.  It may well be that they are all already in my db but given the rarity of our pathology I'm anxious not to miss any cases that could come my way!

 I hope your path report turns out to be as good as possible and I look forward to hearing the finer details once you have them to hand.

Hi TW,

 It was Fizziwizz a

nd Tiffanyz. They commented at the bottom of the chromophobe rcc thread I started the other day.ll

Galrim said:

You are not ignorant, far from :-)

And theres no question in here that will be read as such :-)

As for your path report its as you indicated, identical invasion site as for the renal invasion. When you have a macroscopic invasion the microscopic one is a detail that doesnt have much weight in your prognosis.

/G

Ok, so 'splain it to me, Galrim (Lucy  ).  Why does the macroscopic carry more weight in prognosis than microscopic? And....what generally is the prognosis with renal vein invasion?  

Galrim said:

Here goes

When your prognosis is done, in terms of estimating your risk for recurrence, the oncologists work with a range of prognostic factors.

Some of these independently poses an increased risk for recurrence, others only if they are present in conjunction with other, or very specific, factors.

Some of the primary factors which independently results in an increased risk of recurrence:

Metastatic disease at time of diagnosis

Large tumor size

Tumor grade 3 or 4 (Fuhrman scale 1-4, the lower the better)

Macroscopic invasion of the renal vein, renal fat tissue or the gerotas fascia (macroscopic renal vein invasion increases the risk of spreading to other sites in your body quite a lot, sorry)

Involvement of lymph nodes

Specific agressive sub-types of kidney cancer

Extensive necrosis in the tumor tissue

Sarcomatoid features in the tumor tissue

 

Dependant factors, which doesnt by themselves increase the risk of recurrence but is considered as a part of the "full picture":

Microscopic renal invasion

Age and general health condition

Tumor grade 1 and 2

Less agressive RCC subtypes

 

I probably missed one or two.

 

As for your own prognosis you should sit down with your oncologist and get a detailed breakdown of everything. Obviously macroscopic vein invasion is a quite negative factor, but it is still only a part of the full picture, and statistics are only numbers, not a reflection of your individual case.

/G

 

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Thank you for breaking it down to an understandable level.  Makes much more sense now.