low dose xeloda
the onc just prescribed low dose xeloda ( 500 mg/day) to my dad as maintenance chemo.
does anyone have experience with low does xeloda?
it will be helpful to know what to look out for and any know abt good results as well
rgds
A
update ( 8th July )
just as i was thinking and discussing maintenance chemo with the onc my dad had massive upper GI bleeding ( vomitting clumps of blood). He was in ICU for 3 days, got 2 pints of blood ,total 1 week total in the hospital. He was a little weak because of all this but is bouncing back and doing better each day
good news is that they did all tests ( Xrays, ECG, liver function , renal function,doppler ultrasound) and found no abnormality ( DVT or portal hypertension) and the gastric varice was closed by endoscopy . so he stays NED , But we still dont know what caused the bleed.
Onc doesnt seem to think it was chemo side effect !! i will be meeting him again to discuss options for maintenance !
Comments
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hello nice
to meet you.i am stage 4 colorectal cancer and will be on chemo for life.too many spots in lungs now.i have been on 1000mg/day for almost a year i had hardly any side effects at all maybe some stomach cramping.had to have my spleen out in feb.due to my platelets would not rise to be on avastin with the xeloda.after that they doubled my dose of xeloda to 2000mg/day with the avastin.started having bad hand and foot syndrome with that dosage so i am now on 1600mg/day with the avastin.7 days on 7 days off.with such a low dosage there should not be any problems but if there are any tumors to be controlled by this low dosage i might be a little concerned that it would not do the job.please ask the doctor about this as this seems to be a very low dosage.....Godbless...johnnybegood
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HI JBG,johnnybegood said:hello nice
to meet you.i am stage 4 colorectal cancer and will be on chemo for life.too many spots in lungs now.i have been on 1000mg/day for almost a year i had hardly any side effects at all maybe some stomach cramping.had to have my spleen out in feb.due to my platelets would not rise to be on avastin with the xeloda.after that they doubled my dose of xeloda to 2000mg/day with the avastin.started having bad hand and foot syndrome with that dosage so i am now on 1600mg/day with the avastin.7 days on 7 days off.with such a low dosage there should not be any problems but if there are any tumors to be controlled by this low dosage i might be a little concerned that it would not do the job.please ask the doctor about this as this seems to be a very low dosage.....Godbless...johnnybegood
thanks for yourHI JBG,
thanks for your inputs....there are no visible mets and my dad is currently NED.
The onc wanted to do avastin +xeloda maintenance but he wants to do a laproscopy first to determine state of the peritoneum . So the avastin is being withheld right now.
A
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I did 1000mg/day for a fewvinaykumar said:HI JBG,
thanks for yourHI JBG,
thanks for your inputs....there are no visible mets and my dad is currently NED.
The onc wanted to do avastin +xeloda maintenance but he wants to do a laproscopy first to determine state of the peritoneum . So the avastin is being withheld right now.
A
I did 1000mg/day for a few weeks with no side effects, but then my oncs here increased my dose to 2000mg/day (2 weeks on and 1 week off). I'll be starting FOLFIRI plus avastin in a coupel weeks so I will be back on infusion 5FU for that and not Xeloda.
Tedd
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status ckvinaykumar said:HI JBG,
thanks for yourHI JBG,
thanks for your inputs....there are no visible mets and my dad is currently NED.
The onc wanted to do avastin +xeloda maintenance but he wants to do a laproscopy first to determine state of the peritoneum . So the avastin is being withheld right now.
A
NED, that's great ! Could you quote more CEA, CA199, MCV, esr results and where you are on any off label uses (CIM, celebrex, metformin, etc)?
I would question if he meant xeloda 500 mg twice a day, everyday, no breaks or weekends only, if there is no DPD syndrome. 500 mg per day without DPD syndrome, sounds low even for elderly. Second opinion time ?
We use low dose UFT-LV and off labels, but there are critical low thresholds that things start to rise , so we aim to not set a low dose record.
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Xeloda
I'm so glad that your dad is doing well. 500mg/day Xeloda sounds low. Don't be shy to get a second opinion. My oncologist gave me half of the dose I needed and I went like that for 8 days. If wasn't for this forum my recovery would have been delayed and compromised.
as far as the side effects: keep hands and feet moisterized because xeloda may cause reall bad cracks in the skin. Very unlikely but watch out for diarrhea.
good luck.
laz
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update ( 8th July )
update ( 8th July )
just as i was thinking and discussing maintenance chemo with the onc my dad had massive upper GI bleeding ( vomitting clumps of blood). He was in ICU for 3 days, got 2 pints of blood ,total 1 week total in the hospital. He was a little weak because of all this but is bouncing back and doing better each day
good news is that they did all tests ( Xrays, ECG, liver function , renal function,doppler ultrasound) and found no abnormality ( DVT or portal hypertension) and the gastric varice was closed by endoscopy . so he stays NED , But we still dont know what caused the bleed.
Onc doesnt seem to think it was chemo side effect !! i will be meeting him again to discuss options for maintenance !
0
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