Sutent Side Effects

Texas_wedge said:

L-glutamine

I forgot that I'd meant to point out that mountcarmel referred to glucosamine, not glutamine and they are, of course, very different chemicals and unconnected (without going into amine building blocks and so on).  She was probably thinking of glucosamine sulphate as a supplement (used in treating, e.g. osteoarthritis) and its function in the body is entirely distinct from the many functions of L-glutamine. 

There's no contra-indication to taking both but the one that's more important in this context is L-glutamine, assuming that one's diet is deficient in supplying an adequate amount (a real risk on, e.g. a vegan diet).

Thanks, Tex.  Clearly I did not read Mountcarmel's post closely.  As soon as there was a mention of gastrointestinal issues (and a question about my previous posts dealing with it) I simply commenced to discuss L-Glutamine and never caught the original reference to Glucosamine.

Glucosamine, of course, will have no effect on these issues.  And, just as an aside, there is plenty of debate as to whether it has much effect on treating joint pain and/or osteroarthritis.

Were you a librarian in a previous birth?  You always so easilty catch my typos, grammatical errors, and now my lack of reading skills... 

Hi  Nick,  I have taken Sutent for neuroendocrine cancer for 13 months; 37.5 mg. per day, 3 pills.  I take 3 pills for five weeks and one pill for one week in a six week cycle.  I am female, 5'7" and 140 lbs. My Oncologist is a Research M.D. from UCLA and uses Sutent for many patients.  He told me it does not matter whether you take it with or without food. So I always take it with food.  Only grapefruit juice and green tea are forbidden.  The Sutent has contained the cancer in my lymph nodes and is shrinking and killing the metastatic sites in my bone and liver, those lesions are healing. So the food does not seem to bother the Sutent at all and it would help your stomach.  Thank you for the advice on the Metamucil for diarrhea, it has really helped more than the Immodium.  I take the Sutent first with food and at least an hour later I take the Metamucil. The Metamucil does not interfere with the Sutent, you can tell by looking at my feet  and my white hair that the Sutent is absorbing quite well.  Gatorade May also help, the G2 Gatorade doesn't have all the sugar and it replenishes your electrolytes as well as helping your dehydration. Sorry about your nausea.  Thank you for your research NanoSecond, so kind of you to pass on your knowledge to us.  J

NanoSecond said:

Gatorade G2

Hi J,

Many thanks for your kind words.  However I must take strong exception to your suggestion about consuming Gatorade G2 (or any other version for that matter).

Exactly how much has the nutritional composition changed with Gatorade G2? An 8 ounce serving of G2 has 25 calories, 0 fat calories, 0 grams of fat, 110mg of sodium, 30mg of potassium, 7 grams of carbohydrates, 7 grams of sugar, 0 grams of protein and NO FIBER. An 8 ounce serving of regular Gatorade has 50 calories, 0 fat calories, 0 grams of fat, 110mg of sodium, 30mg of potassium, 14 grams of carbohydrates, 14 grams of sugar, 0 grams of protein and NO FIBER. So G2 has about half the calories and sugar(s) of the original Gatorade.

If you read my guide to nutrition I explain in detail why a lack of fiber, combined with excess sugar(s), should be avoided at all costs for those suffering from any cancer.  It is a shame that many oncologists don't seem to understand (or perhaps the correct term is care) about how tumor cell metabolism differs from normal cell metabolism.  This is true for virtually each and every version of cancer out there.  It is certainly absolutely true for all versions of RCC.

If you are worried about replenishing electrolytes, use Pedialyte.  It does have some glucose - but it is a very small amount that helps its other vital nutrients get easily digested.

For simple hydration - please stick to water. Preferably not from a plastic bottle.  But I digress.

Hey nano.. .are you familiar with a Dr Max Gerson..?  I was "whispered" his name the other day...

Be Well..

Ron

TerriNick said:

drugs

Hi Nano

Sorry I haven't been online. We had a public holiday over here and I took the weekend off for once in my life and didn't work or check anything online.

Re medications Nick has tried Amlodipine and Felodipine and Ramipril without success and with loads of side effects. He is now on Losartan 25mg twice daily and Indapamide 1.5mg once or twice daily. These are still not managing his BP very well at those doses and I think that the cardiologist (who Nick is seeing today on his own) will probably increase the doses. Apart from those, Zantac and Sutent obviously he is not taking any other drugs except for the complementary ones.

Did you want a list of the comp meds I have him taking?

Terri

Yes Terri.  I would like to see all the med's he is taking.  To save bandwidth, why don't you send the list to me directly?

I think you have my email address.  But, if not, its:  n.feldman@videopost.com

Gfarmerrn said:

Sutent

Hi: 

I am a nurse and I find this very encouraging and interested in what 

paper u have written about Sutent my old boss has beeI on Sutent for ten months now and his  dosage was lowered and now his lung mass has doubled in size I would like to know what your thoughts are?

 

thanks 

I am happy to share with anyone my guide to the science and rationale behind what I have called a "proper diet" and "appropriate" supplements for those sufferering from RCC.  It also explains some of the theory behind approaching cancer as a "metabolic" disease.

However, it is a .pdf file (over 57 pages long).  So please email me at: n.feldman@videopost.com

So I can send it as an attachment to an email to you.

Best wishes,

-NanoSecond (Neil)

NanoSecond said:

Slightly outside the box approach to pain relief

If you are interested, one of the best "natural" anti-inflammatory agents available is the spice curcumin - found in Turmeric:

Curcumin has multiple benefits leading with it being highly anti-inflammatory. In animal studies it was shown to protect the lining of the artery walls from damage caused by homocysteine.

 

Curcumin (chemical name = Diferuloylmethane) is the yellow compound found in the spice turmeric. Curcumin has been shown to suppress tumor promotion and proliferation, inflammatory signaling, and angiogenesis (the development of new blood vessels). The anti-inflammatory activity of curcumin is, in part, due to its ability to inhibit enzymes that are necessary for the synthesis of lipid mediators of inflammation. In particular, curcumin inhibits cyclooxygenase-2 (COX-2: this is the same enzyme that is inhibited by the NSAID drug Celebrex®) and lipoxygenase. In studies on the effects of curcumin using human cells in culture it has been shown that the compound blocks the release of inducible nitric oxide synthase (iNOS) and COX-2 from airway epithelial cells, prevents COX-2 expression in mammary epithelial cells, inhibits cytiokine secretion from macrophages, and blocks the release of cytokines and ROS from arterial cells.

 

More here: http://www.ncbi.nlm.nih.gov/pubmed/17569207

 

Here is a study showing that COX-2 inhibitors may make VEGF inhibitors (specifically Sutent) work longer: "COX-2 inhibition enhances the activity of Sunitinib in human renal cell carcinoma xenografts": http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566808/

 

"Conclusion: COX-2 inhibition can extend the effectiveness of VEGFR inhibition. This effect is dependent on the timing of therapy. Clinical trials combining Su and COX-2 inhibitors should be considered as a means delaying time to progression on sunitinib in patients with metastatic cRCC."

Hello NanoSecond, 

Thanks for your link about the COX-2 and curcumin, its very interesting. Anyhow I have been on sutent 2 week on 1 week off now for just over a year now. Its still working because last CT scan 2 weeks go showed continued shrinkage of one tumour in my lung and the other tumour in my lung is now completely undetectable. Anyhow my main question is about curcumin, I am now taking regular doses of it each day (just started with BCM-95 high absorption formula).  My concern is I am reading on some web sites on the internet that curcumin inhibits CYP3A4. I am wondering if you know or  have come across any research that indicates how much it might inhibit CYP3A4 ?. In other words if I am taking curcumin at the same time I’m taking Sutent could the combination of taking both at the same time or even hours apart be increasing the blood levels of Sutent to a dangerous level; similar to the effects grapefruit juice does ?.

Thanks

NanoSecond said:

Gerson

Hi Ron.  Yes, I am familiar with him and his therapy.  Sorry, I don't buy it.  However, there are many aspects of his diet that he got right - but for the wrong reasons.

Hello Nano,

I just joined the cancer survivors network.  

3 years ago I was diagnosed with advanced renal carcinoma and they removed my right kidney.  The only other site I had was on the ischium.  I went through radiation treatment and a year of sutent, at which point I went into remission  Fast forward to 3 months ago and it's back.  I again went through radiation treatments and am now again taking Sutent to treat the site.  My PET scan shows it to be the only site and I am again enjoying all the marvelous side effects that brings such variety to my life.

One that I have not had the pleasure to experience before is pain in the hip joint, which is downright annoying.  The others I have dealt with before (naseua, lack of appetite and general tiredness) and overall I am happy that I am still here

I noted before that you have created documents about sutent and ways to handle the various side effects that can and often do crop up.  I would be greatly interested in any information you would be willing to share.  

Thanks in advance and if you need anything else from me please ask

mike

mike_gilbert said:

Sutent information

Hello Nano,

I just joined the cancer survivors network.  

3 years ago I was diagnosed with advanced renal carcinoma and they removed my right kidney.  The only other site I had was on the ischium.  I went through radiation treatment and a year of sutent, at which point I went into remission  Fast forward to 3 months ago and it's back.  I again went through radiation treatments and am now again taking Sutent to treat the site.  My PET scan shows it to be the only site and I am again enjoying all the marvelous side effects that brings such variety to my life.

One that I have not had the pleasure to experience before is pain in the hip joint, which is downright annoying.  The others I have dealt with before (naseua, lack of appetite and general tiredness) and overall I am happy that I am still here

I noted before that you have created documents about sutent and ways to handle the various side effects that can and often do crop up.  I would be greatly interested in any information you would be willing to share.  

Thanks in advance and if you need anything else from me please ask

mike

A side effect of sutent? Surely not.

When I had my first MRI the radiologist said that my hip must be hurting because of some bone degeneration. I told her it didnt and she promised me it would. It does! A lot! Are you telling me that this could be another side effect of Sutent?

Sonsweet said:

diet and supplements

would you please  send me the PDF regarding diet and supplements. My husband was just diagnosed with nonclear cell papillary ca all over the peritoneal surfaces and has just completed his first cycle of sutent . Mouth sores and diarrhea are his biggest complaint

I'm afraid Neil is no longer with us. I used to use Sutent, and now wholeheartedly recommend flushable moist wipes. Perhaps someone else has his pdf that they can forward to you.