Update on John's (one putt) Nivolumab / Votrient Trial
John had his 36 week scan on Wednesday, January 16. Scan basically showed stability since last scan. But the report came with an initial gasp as his nurse noted what she considered good news: “John’s liver tumor had decreased in size.” That wasn’t particularly well received as John didn’t know he had a liver tumor. After John questioned this, Dr. Hammers confirmed his belief there is no liver tumor and that the radiologist’s comment on the report was not a cause for worry.
Overall, John and I are extremely happy that he continues positive results from the Nivolumab/Votrient trial. John hasn’t posted these results as I believe he’s experiencing a little guilt. Keeps asking why he continues to get positive results when so many aren’t as fortunate.?.?
MEDSCAN MAN – hope you are around to comment and make sense of the liver question. This is what is noted: “Abdomen: In the arterial phase inferiorly in hepatic segment 6/7 a 4.7 mm enhancing lesion has been decreased since prior studies measuring 8.8 mm on the study of 8/1/2012.”
_____________________________________
John’s History at Johns Hopkins:
10/14/11 – Diagnosed with Kidney cancer clear cell/grade 4/stage 4 – with sarcomatoid features and lung mets; also has soft tissue mass in shoulder area and pelvic area.
Symptoms: weight loss followed by cough
11/1/11 – Surgery for removal of right kidney (nephrectomy)
Treatments to date:
January & February 2012 -HDIL2 treatment/first round 14 doses/2nd round 10 doses;
(discontinued after February 2012 as scan did not merit continuation)
5/10/2012 – Began Nivolumab/Votrient trial BMS 936558 (also began Xgeva);
6/20/2012–CT scan showed 31% reduction in tumor burden;
8/1/2012–CT scan showed add'l 11% tumor reduction for total of 42%:
9/12/2012 – CT scan showed 46% reduction in tumor burden (4% addl.)
10/24/2012-CT scan showed 47% reduction (1% add’l.)
Comments
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Good News
Alice I am so happy you got some good news with his scans. John should not feel guilty about getting good results, that gives all of us hope when we read about good news. I'm praying the Votrient continues to maintain the cancer.
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Yea, 1 putt!DMike said:Update
Hi Alice,
I'm vey happy for John and you. Great news on the stability. Hopefully Jeff will reply and provide some answers to your questions.
Good news is always welcome!
--David
I am smiling! Keep up the recovery. I may get more scans than most here. I know each time someone different reads the scans, my results vary. One time there is a tumor, next time there isn't. Broken rib on my left becomes a broken rib on my right. One time the radiologist reported on my stent in my cardiac widow maker. After I asked for a clarification, he claimed the transcriptionist made an error. Yeah, right. HEY! NO DRINKING ON THE JOB!!!!!!!! Sheesh, we take this stuff seriously.
Alice, you wonderful, beautiful, and damn smart woman, John is a lucky man. I hope he appreciates you. If not, I can send some criminally insane bikers his way for a talk. Even if they don't know many words. By the way keep your helmet handy..... Some time back you mentioned to me that I had been conspicuously absent. So, where have you been? I guess we all need some down time once in a while. FLY.
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Good news!foxhd said:Yea, 1 putt!
I am smiling! Keep up the recovery. I may get more scans than most here. I know each time someone different reads the scans, my results vary. One time there is a tumor, next time there isn't. Broken rib on my left becomes a broken rib on my right. One time the radiologist reported on my stent in my cardiac widow maker. After I asked for a clarification, he claimed the transcriptionist made an error. Yeah, right. HEY! NO DRINKING ON THE JOB!!!!!!!! Sheesh, we take this stuff seriously.
Alice, you wonderful, beautiful, and damn smart woman, John is a lucky man. I hope he appreciates you. If not, I can send some criminally insane bikers his way for a talk. Even if they don't know many words. By the way keep your helmet handy..... Some time back you mentioned to me that I had been conspicuously absent. So, where have you been? I guess we all need some down time once in a while. FLY.
Fox, you make me laugh!
Alice, that's great news about your husband. Great hope for those of us on Votrient. So happy for you....
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You are always great for thefoxhd said:Yea, 1 putt!
I am smiling! Keep up the recovery. I may get more scans than most here. I know each time someone different reads the scans, my results vary. One time there is a tumor, next time there isn't. Broken rib on my left becomes a broken rib on my right. One time the radiologist reported on my stent in my cardiac widow maker. After I asked for a clarification, he claimed the transcriptionist made an error. Yeah, right. HEY! NO DRINKING ON THE JOB!!!!!!!! Sheesh, we take this stuff seriously.
Alice, you wonderful, beautiful, and damn smart woman, John is a lucky man. I hope he appreciates you. If not, I can send some criminally insane bikers his way for a talk. Even if they don't know many words. By the way keep your helmet handy..... Some time back you mentioned to me that I had been conspicuously absent. So, where have you been? I guess we all need some down time once in a while. FLY.
You are always great for the soul Fox. Thank you. And you're right about those radiologists. I remember Dena Battle (Chris Battle's wife) talking about Chris's scan referencing his uterus. Really??????
You're right I have been more scarce than usual but I'm getting ready to retire after 43 years in the banking world. And tying up loose ends has occupied much of the past couple weeks. But after January 31, I'm retired!!!! WOO HOO. I don't know what it will be like NOT to go to work, but promise to make everyone (John included) sick of having me around! And enjoy every minute of it!!!!
As always, John and I love having you on our sidelines!!!!
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good newsKJones1969 said:Good News
Alice I am so happy you got some good news with his scans. John should not feel guilty about getting good results, that gives all of us hope when we read about good news. I'm praying the Votrient continues to maintain the cancer.
Thanks K. Appreciate your keeping us in your prayers as we do you and your hubby. Let's keep our fingers crossed 2013 is a good year for us all!
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Happy Newstacyarts said:Happy news!!!
What great news, stability for the next 20 years would sure be acceptable. I am so very happy for the two of you.
Great to hear from you; thank you.
We've been wondering how your recovery is going and if you've returned to trial????? We're all stronger together!
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Alice's retirementalice124 said:Happy News
Great to hear from you; thank you.
We've been wondering how your recovery is going and if you've returned to trial????? We're all stronger together!
Wow! that is exciting! That's great news! I hope you have nothing but good moments.
By the way, GO PATS!..........(you can't have all good moments)
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good newsDMike said:Update
Hi Alice,
I'm vey happy for John and you. Great news on the stability. Hopefully Jeff will reply and provide some answers to your questions.
Good news is always welcome!
--David
Hey David,
Thanks for the cheering.
I'm behind in my reading on Board and don't know how you are planning to treat lung nodules. Has that been determined? I tried searching for it but was unsuccessful.
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Thanks Jam. We are happy andjam66 said:Good news!
Fox, you make me laugh!
Alice, that's great news about your husband. Great hope for those of us on Votrient. So happy for you....
Thanks Jam. We are happy and know how fortunate we are. Hope it's a Win for you too. Go Votrient.
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foxhd said:
Alice's retirement
Wow! that is exciting! That's great news! I hope you have nothing but good moments.
By the way, GO PATS!..........(you can't have all good moments)
I have continued the mdx portion of trial and will continue sutent next Thursday. My next scans are the 31st, boy lots of scan anxiety. I get my brace off next Thursday and then should be able to start putting a little weight on my leg. Thus far not much pain but I'm sure that I will hate my physiCal therapist since I've been on my back for over 3 months now but I'm ready!!
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Catch upjam66 said:Good news!
Fox, you make me laugh!
Alice, that's great news about your husband. Great hope for those of us on Votrient. So happy for you....
Jennifer, how long have you been on Votrient? It's been almost two years now since your original op. so your Family will be happy to see you up and at it. I reckon the IL2 will have set you up to benefit well from Votrient, particularly since I seem to remember you did fine on Sutent and the side-effects on Votrient are much gentler than on Sutent - are you finding it so? Are your kids all taking your situation in their stride. I'm guessing they are and are helping to keep you buoyed up.
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therapisttacyarts said:I have continued the mdx portion of trial and will continue sutent next Thursday. My next scans are the 31st, boy lots of scan anxiety. I get my brace off next Thursday and then should be able to start putting a little weight on my leg. Thus far not much pain but I'm sure that I will hate my physiCal therapist since I've been on my back for over 3 months now but I'm ready!!
Good luck with the scans. I understand being anxious. We poor therapists. We meet people and get paid to hurt them. No wonder we aren't the patients favorite people. Here's hoping you have a good one. Knowing how much to do is tough. You never want to do too much and set yourself back. A good therapist will know the proper rate of progress for you.
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PTfoxhd said:therapist
Good luck with the scans. I understand being anxious. We poor therapists. We meet people and get paid to hurt them. No wonder we aren't the patients favorite people. Here's hoping you have a good one. Knowing how much to do is tough. You never want to do too much and set yourself back. A good therapist will know the proper rate of progress for you.
I was going to tell David he'd be OK if his PT is foxy - next best thing - getting some Foxy counsel.
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Presumed innocentTexas_wedge said:PT
I was going to tell David he'd be OK if his PT is foxy - next best thing - getting some Foxy counsel.
Alice, do persuade John to plead not guilty. I tend to share his feelings.
However, we shouldn't feel guilty - the reason we're both feeling so good is that it's the reward for virtue, seeing as we're lawyers - I'm confident Gary will confirm the accuracy of this conclusion.
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"By the way, GOfoxhd said:Alice's retirement
Wow! that is exciting! That's great news! I hope you have nothing but good moments.
By the way, GO PATS!..........(you can't have all good moments)
"By the way, GO PATS!"
hmmmmmmmmmmmmmm - where did they go?
".........you can't have all good moments" - but this one is mine FOX!
Rooted for the Ravens - not against you Fox. For the record, still adore Tom Brady!
ELF
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Presumed InnocentTexas_wedge said:Presumed innocent
Alice, do persuade John to plead not guilty. I tend to share his feelings.
However, we shouldn't feel guilty - the reason we're both feeling so good is that it's the reward for virtue, seeing as we're lawyers - I'm confident Gary will confirm the accuracy of this conclusion.
LOAO!!!
Virtue and lawyer in the same sentence. Can't wait for Gary to check in. . .
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dupTexas_wedge said:Presumed innocent
Alice, do persuade John to plead not guilty. I tend to share his feelings.
However, we shouldn't feel guilty - the reason we're both feeling so good is that it's the reward for virtue, seeing as we're lawyers - I'm confident Gary will confirm the accuracy of this conclusion.
dup
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Right attitudetacyarts said:I have continued the mdx portion of trial and will continue sutent next Thursday. My next scans are the 31st, boy lots of scan anxiety. I get my brace off next Thursday and then should be able to start putting a little weight on my leg. Thus far not much pain but I'm sure that I will hate my physiCal therapist since I've been on my back for over 3 months now but I'm ready!!
Know the last several months have been hard but am keeping fingers and toes crossed that you've turned the corner. Know physical therapy will be tough but you're tougher. Great attitude!!!
Keep us posted!!!
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