anyone else been asked for her2 receptor status to tailor chemo/antibody treatment

pete43lost_at_sea
pete43lost_at_sea Member Posts: 3,900 Member
in Colorectal Cancer #1
i got asked this today.
possibly something we should all know given that 11% of us can benefit from more effective treatments i suspect.

just curious ?

hugs,
Pete


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648993/

Comments

  • Lovekitties
    Lovekitties Member Posts: 3,364 Member
    #2
    Hi Pete
    The study paper you sent us to was published in January 2009.

    Here is the conclusion of those doing the study:
    ____________________________________
    Conclusion.

    We have not demonstrated compelling evidence supporting a potential role for Herceptin in colorectal carcinoma as shown in breast cancer. Similarly we have not revealed that it is an important prognostic indicator. Some patients who overexpress HER-2 (11%) will respond to Herceptin. The evolution of signature genes in colorectal cancer and molecular profiling may facilitate identification of the small subset of patients overexpressing HER-2 who will have a favourable response to Herceptin therapy.
    ___________________________________

    Given this conslusion, I doubt it is on the radar of most doctors. I would also suspect that given it's low sucess rate (only some of the 11%) with colorectal cancer the potential side effect I found on another site would cause most to side step it if other things are better suited. That is not to say there aren't riskes in all the "medical" treatment options.

    __________________________________________________________

    Perhaps the most important side effect to note is Herceptin's potential to cause severe cardiac problems, including heart failure.

    ____________________________________

    Marie who loves kitties
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #3
    thanks marie
    your conclusions are correct based on the paper,
    i have to apologise, the paper i put to explain the receptor background for colorectal,

    so what new and available for me is another piggy back trifuntional antibody for her2,
    that can be helpful for some colorectals.

    so if i am her2 i get it. only one place on the planet, this antibody is still in testing.

    i was curious if anyone else had been asked, i guess the answer is no.

    this her2 antibody works with removab, its made by the same company. i would encourage patients to ask for their her2 status. you need to have your parrafin tumour slide reviewed. i hope i am positive her2. the immune sysytem needs all the help it can get.

    hugs,
    pete
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #4
    here is the study for + her2 receptor status
    i am so kind and loving, but a touch frustrated I cannot get either of my sydney oncologists to look up my her 2 status. I just need a + to have another effective antibody treatment.

    I have posted this on my blog as well.

    http://meeting.ascopubs.org/cgi/content/abstract/26/15_suppl/3071

    its not enough that for 10 months my onc says go away and grow the tumour, now I ask them to get the slide reviewed for her2 status and it takes 9 days to get no answer. I have made a follow call and was promised. good service speaks for itself, so does poor service.

    does someone fighting for survival deserve better service, after all, they only have to call the lab where the tissue is stored. I could probably call the lab myself, pretend to be doctor pete and get the answer myself, but its against my ethics. I will give them a few more days. but not even getting an email response from bell my sydney onc, that sux. everyday in the clinic costs, I feel better, i have got this off my chest and I found the link for the antibody study.

    hugs,
    Pete
  • Lovekitties
    Lovekitties Member Posts: 3,364 Member
    #5
    pete43lost_at_sea said:

    here is the study for + her2 receptor status
    i am so kind and loving, but a touch frustrated I cannot get either of my sydney oncologists to look up my her 2 status. I just need a + to have another effective antibody treatment.

    I have posted this on my blog as well.

    http://meeting.ascopubs.org/cgi/content/abstract/26/15_suppl/3071

    its not enough that for 10 months my onc says go away and grow the tumour, now I ask them to get the slide reviewed for her2 status and it takes 9 days to get no answer. I have made a follow call and was promised. good service speaks for itself, so does poor service.

    does someone fighting for survival deserve better service, after all, they only have to call the lab where the tissue is stored. I could probably call the lab myself, pretend to be doctor pete and get the answer myself, but its against my ethics. I will give them a few more days. but not even getting an email response from bell my sydney onc, that sux. everyday in the clinic costs, I feel better, i have got this off my chest and I found the link for the antibody study.

    hugs,
    Pete

    Hi Pete
    Is it possible for one of the docs there at the clinic to call and make the request? Or to fax a request to your Aussie doc?

    Some times another doc has more pull at getting things like this done than just the patient who is in the fight.

    Hope you hear soon.

    Hugs,

    Marie who loves kitties
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #6
    Lovekitties said:

    Hi Pete
    Is it possible for one of the docs there at the clinic to call and make the request? Or to fax a request to your Aussie doc?

    Some times another doc has more pull at getting things like this done than just the patient who is in the fight.

    Hope you hear soon.

    Hugs,

    Marie who loves kitties

    thanks marie
    great suggestion, i will give it a try tomorrow.
    hugs,
    pete
  • Minnesotagirl
    Minnesotagirl Member Posts: 141
    #7
    pete43lost_at_sea said:

    thanks marie
    great suggestion, i will give it a try tomorrow.
    hugs,
    pete

    Just thinking about you Pete
    Just wanted to pop in and say "proud of you Pete". Keep the faith my friend and continue to give "c" a good kick in the butt! Although I don't post much, I still follow your storyline. Praying for you Pete and all on this board.

    "Minnesotagirl"
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #8
    Minnesotagirl said:

    Just thinking about you Pete
    Just wanted to pop in and say "proud of you Pete". Keep the faith my friend and continue to give "c" a good kick in the butt! Although I don't post much, I still follow your storyline. Praying for you Pete and all on this board.

    "Minnesotagirl"

    thanks minnesotagirl
    some times prayers come when we really need them. just like tonight. thank you again!
    godbless us all, and may all our lives be full of peace and love.

    i know the c is cancer, but my prayer tonight is for continued courage. i miss my family so much, i know the german treatment idea is my responsibility, but often the reality is more challenging than the idea.

    hugs,
    pete
  • Minnesotagirl
    Minnesotagirl Member Posts: 141
    #9
    pete43lost_at_sea said:

    thanks minnesotagirl
    some times prayers come when we really need them. just like tonight. thank you again!
    godbless us all, and may all our lives be full of peace and love.

    i know the c is cancer, but my prayer tonight is for continued courage. i miss my family so much, i know the german treatment idea is my responsibility, but often the reality is more challenging than the idea.

    hugs,
    pete

    Continued Courage it is
    So tonight I shall pray for continued courage for Pete. I will also pray for grace and mercy for you as well. I can't imagine how much your family must miss you...keep the faith Pete and above all stay strong and well.

    "Minnesotagirl"

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