cisplatin & chronic kidney disease CKD

friendly frieda said:

Stage 2C
During surgery they were certain it was a Stage 3 but when all (many) of the biopsies were returned they downgraded it to a 2C since it had not invaded any of the organs they saw it on. We were elated until we discovered that "C" is the most aggressive! Yes, I'm blessed. And no symptoms of kidney disease. I was referred to a nephrologist because my GFR is low and something with the bun creatinine ratio. Were you ovarian? What stage? Frieda

kayandok said:

I had cisplatin
in 2009 (6 infusions). I live in Japan and it is required here that you have to be hospitalized for cisplatin infusions to flush the chemo with hydration before and after for 2 days, to prevent any damage to the kidneys. Fortunately, it did not affect my kidneys at all. I have chosen though, to never go on cisplatin again, because of the extreme side effects.

Wishing you the best,
kathleen

Hi,

i have just completed my first cycle of IP/IV Cisplatin and Taxol combo. My creatinine levels went up indicating possible kidney disease as a side effect from the Cisplatin. I have been getting two liters of IV fluid every other day in an attempt to bring the Creatine level down. It hasn't worked so far. In fact the Creatinine continues to climb. I've had so much fluid pumped into me without it really leaving my body. My abdomen has become so swollen from the fluid that I can't zip my coat. I gained fifteen pounds in the past week. It is so uncomfortable. I had shortness of breath just trying to keep up with my daughter who is a New Yorker(they all walk super fast). I have always been an athlete so this sudden change in my health is throwing me, and my doctors, for a loop.

Now my doctor wants to stop the fluids and just monitor my vital signs and do labs every day to see if the Creatinine will come down on it's own.

has anyone else experienced this? Kelly

Kaleena said:

Kidney Issues

I was diagnosed with Endometrial Adenocarcinoma in 2005  (at age 45) and went through the treatment of Carbo/Gemzar and then three doses of bracytherapies.   I never had high blood pressure or other issues.   However, in January of this year, I developed hydrouteronephrosis of the left ureter causing my left kidney to swell.    The urologist I went to see indicated that I wasn't having any symptoms and just sent me back to my gyne/onc.  However, within several months my left kidney shrunk and I also developed high blood pressure for which I have to take medication for now since August.   Originally thought that the hydronephrosis was caused by a soft tissue mass that I have but my new urologist believes that the radiation (bracytherapies) caused scar tissue to developed whereby causing a blockage.   I now have to have stent placed in to save my kidney which has already decreased in size and has some loss.

I have been trying to find the answers that you have been asking but I did not get anywhere as I still want to protect both of my kidneys.   I keep asking about certain diets etc but the urologist says there isn't any.   My eGFR prior to stent was 59 and after stent is now 65.   My creatinine was usually in the .70s but this year was slowly going up and at one time was 1.1 but still no one seemed to take notice.    

I feel that I may be experiencing something now with my right kidney but I don't exhibit symptoms - it is just feelings (like I had with my left side).   I will find out sometime in March when I have another PET scan.

If you find anything else out about diet, etc., let me know.

Who'd have thunk that pumping toxic chemicals throughout your body may cause "other" issues.  Just a wild guess, but I would think so.  Based on your mirage of posts, seems like the fallout from chemo/radiation has created a second money pit for the "medical community."