just published research on nutrients,genes and cancer:

coloCan
coloCan Member Posts: 1,944 Member
edited August 2012 in Colorectal Cancer #1
medicalxpress.com/news/2012-08-documents-links-nutrients-genes-cancer.html

(original pub isn't free,so far, so this is a report on it)

Comments

  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #2
    GMO etc
    Boycott buying GMO, albeit FDA, FTC and companies have made identifying GMO content more difficult. You can also buy from known sources, or raise more of your own. Can even go to regions, or countries, that have more what you want or need. The US corporate-expanded government axis that we see is literal fascism, the economic system, it's likely to get more intense before it gets better.
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #3
    thanks Steve, and tans and diet offers us with crc healthy hope
    Hugs,
    Pete
  • coloCan
    coloCan Member Posts: 1,944 Member
    #4
    tanstaafl said:

    GMO etc
    Boycott buying GMO, albeit FDA, FTC and companies have made identifying GMO content more difficult. You can also buy from known sources, or raise more of your own. Can even go to regions, or countries, that have more what you want or need. The US corporate-expanded government axis that we see is literal fascism, the economic system, it's likely to get more intense before it gets better.

    Little stickers with numbers on fruit,etc
    In the US,sometimes you find little stickers with a number on it affixed to apples,pears,etc....(While i keep forgeting to look myself),supposedly a
    4-digit number=conventionally grown
    5-digit starting with a 9=organic
    5-digit starting withan 8=GMO

    There is a very strong link between Monsanto and its cohorts and that part of the FDA that pertains to GMOs and pesticides,etc giving such firms an enormous influence at a msjor gov't agancy supposed to monitior such companies-nothing gnu here.......

    Worst is that "we the people" seem to have no say in this matter and the only research that supports GMOs is paid for or sponsored by these huge "agribusinesses"
  • tommycat
    tommycat Member Posts: 790 Member
    #5
    coloCan said:

    Little stickers with numbers on fruit,etc
    In the US,sometimes you find little stickers with a number on it affixed to apples,pears,etc....(While i keep forgeting to look myself),supposedly a
    4-digit number=conventionally grown
    5-digit starting with a 9=organic
    5-digit starting withan 8=GMO

    There is a very strong link between Monsanto and its cohorts and that part of the FDA that pertains to GMOs and pesticides,etc giving such firms an enormous influence at a msjor gov't agancy supposed to monitior such companies-nothing gnu here.......

    Worst is that "we the people" seem to have no say in this matter and the only research that supports GMOs is paid for or sponsored by these huge "agribusinesses"

    thank you
    Very good information here...thank you Colocan.
    Tommycat
  • coloCan
    coloCan Member Posts: 1,944 Member
    #6
    pete43lost_at_sea said:

    thanks Steve, and tans and diet offers us with crc healthy hope
    Hugs,
    Pete

    and you're right, Pete, in also emphasizing exercise,
    wherein breast and colon cancers are mentioned specifically:

    newswise.com/articles/view/593032?print-article

    "Exercise can help pstients but few oncologists suggest it"......til now,as with vitamin D-3:

    foodconsumer.org/newsite/Nutrition/vitamin_d_breast_colon_lung_cancer_0828120653.html
  • peterz54
    peterz54 Member Posts: 341
    #7
    excerpt
    "He saw substances like amino acids, vitamin D, ethanol, ginseng extract, the tomato carotenoid lycopene, the turmeric component curcumin, pomegranate juice, fish oil and others affecting gene expression in breast, colorectal, prostate, skin, lung and other cancers. Typically, the substances acted epigenetically, which is to say they turned metastasis suppressor genes on or off. "So these epigenetic mechanisms are influenced by what you eat," he says. "That may also be related to how the metastasis suppressor genes are being regulated. That's a very new area of research that has largely not been very well explored in terms of diet and nutrition." Meadows says his study reinforces two concepts."

    full article >> links between nutrients, genes and cancer spread

    this is consistent with other research, including that of the Angiogenesis Foundation
  • steved
    steved Member Posts: 834 Member
    #8
    This article
    The full article is worth a read at

    http://rd.springer.com/static-content/0.5088/pdf/278/art%3A10.1007%2Fs10555-012-9369-5.pdf?token=1346236414612--228c5c23f5a932ce709dec3f1acc42e51bd59477afbf2c5e2e29e04f8cc27ead2de07583ab3c6b03adcf23041880d4c1c008725bfe517a03f1c1491824093dad&doi=10.1007/s10555-012-9369-5&contentType=article

    IT talks in more details about which nutrient is associated with evidence of supppression of mestasis in which cancer. Some of those mentioned in colorectal cancer include flavones (found in fruit and veg mainly), vitamin D and folate (suggesting a diet with adeuqate fruit and veg and sunlight exposure is a good start). It also list enough wierd supplements to drive PEte into a frenzy of new experiments!

    Good to read a well written intelligent review of some of the literature that points to more research being needed and good to see it published in a decent peer review journal with a good impact factor- suggests the mainstream conventional system is taking this seriously. It has triggered the usual inatipharma paranoid discussion on line elsewhere but in truth is a step forward to ligitimising more research in this area.

    Steve


    PS used Phils tutorial on making a link using the a href=.... system and didn't work so yo have to cut and paste above link- anyone suggest what I was doing wrong?
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #9
    steved said:

    This article
    The full article is worth a read at

    http://rd.springer.com/static-content/0.5088/pdf/278/art%3A10.1007%2Fs10555-012-9369-5.pdf?token=1346236414612--228c5c23f5a932ce709dec3f1acc42e51bd59477afbf2c5e2e29e04f8cc27ead2de07583ab3c6b03adcf23041880d4c1c008725bfe517a03f1c1491824093dad&doi=10.1007/s10555-012-9369-5&contentType=article

    IT talks in more details about which nutrient is associated with evidence of supppression of mestasis in which cancer. Some of those mentioned in colorectal cancer include flavones (found in fruit and veg mainly), vitamin D and folate (suggesting a diet with adeuqate fruit and veg and sunlight exposure is a good start). It also list enough wierd supplements to drive PEte into a frenzy of new experiments!

    Good to read a well written intelligent review of some of the literature that points to more research being needed and good to see it published in a decent peer review journal with a good impact factor- suggests the mainstream conventional system is taking this seriously. It has triggered the usual inatipharma paranoid discussion on line elsewhere but in truth is a step forward to ligitimising more research in this area.

    Steve


    PS used Phils tutorial on making a link using the a href=.... system and didn't work so yo have to cut and paste above link- anyone suggest what I was doing wrong?

    thanks always steve
    see the new post, never a dull day in cea land.

    hugs,
    Pete

    ps it used to be so boring pushing the fuit and veg wagon, its so great to have friends that have faith in these ultra radical dangerous therapies. tonight my wife and kids, placed our big weekly organic order. i also had some organic freerange chicken.

    i will check it out, but i have to finish my due diligence on ndl.

    my rule is never to start more than one new cancer therapy on the same day.
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #10
    peterz54 said:

    excerpt
    "He saw substances like amino acids, vitamin D, ethanol, ginseng extract, the tomato carotenoid lycopene, the turmeric component curcumin, pomegranate juice, fish oil and others affecting gene expression in breast, colorectal, prostate, skin, lung and other cancers. Typically, the substances acted epigenetically, which is to say they turned metastasis suppressor genes on or off. "So these epigenetic mechanisms are influenced by what you eat," he says. "That may also be related to how the metastasis suppressor genes are being regulated. That's a very new area of research that has largely not been very well explored in terms of diet and nutrition." Meadows says his study reinforces two concepts."

    full article >> links between nutrients, genes and cancer spread

    this is consistent with other research, including that of the Angiogenesis Foundation

    thanks also peter
    this is music to my ears. now if some of these cool ideas start translating to measurable blood results and feeling just better than fine, well then we can have our first official csn 128 alt cured party. i will invite everyone, that will be a day i cannot wait for. to be honest i don't care if i am not the first, but it would be nice, just as long as i don't miss out on the party.

    hugs,
    pete
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #11
    still flogging a dead horse, enduracell broccoli powder
    i took my bag of supplements to chicago, it weighted 20 kgs as well as my tcm.
    the integrative doctors would have been amazed but i kept my bag of tricks closed.

    on the top of the list is broccoli sprout powder.

    now we have diet and exercise accepted by some wonderful enthusiastic cancer friends.

    next battle is supplements, well lets just bring it on.

    i cannot be defeated on broccoli powder, just read about nrf2. of course just rely on your onc to save your life if you want, we all have choice.

    my onc never backed any onbe of my therapies, she still does not.

    think of it, one chemo shot is equal to a long lifetimes supply of broccoli powder. of course i hope this stuff helps me, so far so good. but dam these crc cells are persistent. lucky i am more persistent.

    I am human as well, i need encouragement. i started on all these therapies on my gut feelings and guesses and some research. but the longer i live, the more research comes out, the more confident i get.

    A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics
    Topics in Current Chemistry 2012,
    Zheng-Yuan Su, Limin Shu, Tin Oo Khor, Jong Hun Lee, Francisco Fuentes, Ah-Ng Tony Kong
    Look Inside Get Access
    Abstract
    Oxidative stress is caused by an imbalance of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the antioxidative stress defense systems in cells. ROS/RNS or carcinogen metabolites can attack intracellular proteins, lipids, and nucleic acids, which can result in genetic mutations, carcinogenesis, and other diseases. Nrf2 plays a critical role in the regulation of many antioxidative stress/antioxidant and detoxification enzyme genes, such as glutathione S-transferases (GSTs), NAD(P)H:quinone oxidoreductase 1 (NQO1), UDP-glucuronyl transferases (UGTs), and heme oxygenase-1 (HO-1), directly via the antioxidant response element (ARE). Recently, many studies have shown that dietary phytochemicals possess cancer chemopreventive potential through the induction of Nrf2-mediated antioxidant/detoxification enzymes and anti-inflammatory signaling pathways to protect organisms against cellular damage caused by oxidative stress. In addition, carcinogenesis can be caused by epigenetic alterations such as DNA methylation and histone modifications in tumor–suppressor genes and oncogenes. Interestingly, recent studies have shown that several naturally occurring dietary phytochemicals can epigenetically modify the chromatin, including reactivating Nrf2 via demethylation of CpG islands and the inhibition of histone deacetylases (HDACs) and/or histone acetyltransferases (HATs). The advancement and development of dietary phytochemicals in cancer chemoprevention research requires the integration of the known, and as-yet-unknown, compounds with the Nrf2-mediated antioxidant, detoxification, and anti-inflammatory systems and their in vitro and in vivo epigenetic mechanisms; human clinical efficacy studies must also be performed.
  • jen2012
    jen2012 Member Posts: 1,607 Member
    #12
    pete43lost_at_sea said:

    still flogging a dead horse, enduracell broccoli powder
    i took my bag of supplements to chicago, it weighted 20 kgs as well as my tcm.
    the integrative doctors would have been amazed but i kept my bag of tricks closed.

    on the top of the list is broccoli sprout powder.

    now we have diet and exercise accepted by some wonderful enthusiastic cancer friends.

    next battle is supplements, well lets just bring it on.

    i cannot be defeated on broccoli powder, just read about nrf2. of course just rely on your onc to save your life if you want, we all have choice.

    my onc never backed any onbe of my therapies, she still does not.

    think of it, one chemo shot is equal to a long lifetimes supply of broccoli powder. of course i hope this stuff helps me, so far so good. but dam these crc cells are persistent. lucky i am more persistent.

    I am human as well, i need encouragement. i started on all these therapies on my gut feelings and guesses and some research. but the longer i live, the more research comes out, the more confident i get.

    A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics
    Topics in Current Chemistry 2012,
    Zheng-Yuan Su, Limin Shu, Tin Oo Khor, Jong Hun Lee, Francisco Fuentes, Ah-Ng Tony Kong
    Look Inside Get Access
    Abstract
    Oxidative stress is caused by an imbalance of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the antioxidative stress defense systems in cells. ROS/RNS or carcinogen metabolites can attack intracellular proteins, lipids, and nucleic acids, which can result in genetic mutations, carcinogenesis, and other diseases. Nrf2 plays a critical role in the regulation of many antioxidative stress/antioxidant and detoxification enzyme genes, such as glutathione S-transferases (GSTs), NAD(P)H:quinone oxidoreductase 1 (NQO1), UDP-glucuronyl transferases (UGTs), and heme oxygenase-1 (HO-1), directly via the antioxidant response element (ARE). Recently, many studies have shown that dietary phytochemicals possess cancer chemopreventive potential through the induction of Nrf2-mediated antioxidant/detoxification enzymes and anti-inflammatory signaling pathways to protect organisms against cellular damage caused by oxidative stress. In addition, carcinogenesis can be caused by epigenetic alterations such as DNA methylation and histone modifications in tumor–suppressor genes and oncogenes. Interestingly, recent studies have shown that several naturally occurring dietary phytochemicals can epigenetically modify the chromatin, including reactivating Nrf2 via demethylation of CpG islands and the inhibition of histone deacetylases (HDACs) and/or histone acetyltransferases (HATs). The advancement and development of dietary phytochemicals in cancer chemoprevention research requires the integration of the known, and as-yet-unknown, compounds with the Nrf2-mediated antioxidant, detoxification, and anti-inflammatory systems and their in vitro and in vivo epigenetic mechanisms; human clinical efficacy studies must also be performed.

    thank you
    Just wanted to thank you all for sharing so much great information ... and hope, something the docs aren't giving us a lot of. My husband's diagnosis is still so new and it's been such a difficult 2 weeks. I've spent so many hours on this website and others trying to gather information and survival stories. It has been so helpful.
  • smokeyjoe
    smokeyjoe Member Posts: 1,425 Member
    #13
    jen2012 said:

    thank you
    Just wanted to thank you all for sharing so much great information ... and hope, something the docs aren't giving us a lot of. My husband's diagnosis is still so new and it's been such a difficult 2 weeks. I've spent so many hours on this website and others trying to gather information and survival stories. It has been so helpful.

    Steve I couldn't open the
    Steve I couldn't open the link you posted....which weird supplements?? Thanks L
  • steved
    steved Member Posts: 834 Member
    #14
    smokeyjoe said:

    Steve I couldn't open the
    Steve I couldn't open the link you posted....which weird supplements?? Thanks L

    Try this
    Try going to the site

    http://rd.springer.com/article/10.1007/s10555-012-9369-5

    and opening the pdf file or downloading the article.

    Some of the things that caught my eye included the delight of taking 'mouse serum' as well as many compounds I have never heard of such as Isoliquiritigenin and Phenethylisothiocyanate.

    Was most disappointed to see that alcohol hasn;t got proven value in colorectal cancer as that is probably the only one on the list I regularly do take!

    steve

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