Avastin news

peterz54
peterz54 Member Posts: 341
edited August 2012 in Colorectal Cancer #1
short video.
Avastin & Improving Survival

or June 2012 article
ASCO 2012: Continuing bevacizumab with second-line chemotherapy after first progression extends survival for advanced colorectal cancer

Comments

  • steved
    steved Member Posts: 834 Member
    #2
    Important stuff
    This was mentioned a couple of months back but good to reinforce the message: if you are on a cytotoxic agent eg oxaliplatin or irinitecan with avastin and your tumour progresses to the point where you decide to change the treatment DON'T STOP THE AVASTIN- just change the cytotoxic (previosuly normal protocols said to stop avastin if you cancer progresses while on it).

    steve
  • PhillieG
    PhillieG Member Posts: 4,866 Member
    #3
    Thanks Peter
    Always nice to see positive news and progress in the battle, whatever the weapon being used is.
    -phil
  • luvinlife2
    luvinlife2 Member Posts: 172 Member
    #4
    Thank You !!
    I'll be keeping this for my onc when and if the time comes that my first protocol ceases to do it's thing. Avastin definitely works for me. In BC, it's only given with the first protocol and discontinued per all the old info so this will come in handy!
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #5
    trying to get lifetime VEGF protection from day 1
    Given the terrific economic pressures that are going to be brought to bear, my question is how does Avastin compare, and interact with, cimetidine (Tagamet). Both drugs reduce VEGF-A, although with different overall strengths, benefits and side effects.

    CRC stage II or III patients with significant CA19-9 stained tumor tissues that are highly associated with the great majority of those that recur and die without extra treatment. Cimetidine survival appears grossly superior to Avastin, not to mention the better side effect profile, in these high risk, stage II-III patients.

    There is very limited cimetidine data on stage IV CRC, but that data, combined with other stage IV adenocarcinomas treated with cimetidine, speculatively appears very favorable to patients with CA19-9 biomarked (and presumably more so, CSLEX biomarked) tumors.

    My supposition is that longer term cimetidine from day 1 can provide more coverage in low tumor dissemination for stage 4 timewise with less debility and risks for some stage IV patients. If push comes to shove on VEGF-A, we will consider titrating Avastin with cimetidine for some optimum use.
  • smokeyjoe
    smokeyjoe Member Posts: 1,425 Member
    #6
    tanstaafl said:

    trying to get lifetime VEGF protection from day 1
    Given the terrific economic pressures that are going to be brought to bear, my question is how does Avastin compare, and interact with, cimetidine (Tagamet). Both drugs reduce VEGF-A, although with different overall strengths, benefits and side effects.

    CRC stage II or III patients with significant CA19-9 stained tumor tissues that are highly associated with the great majority of those that recur and die without extra treatment. Cimetidine survival appears grossly superior to Avastin, not to mention the better side effect profile, in these high risk, stage II-III patients.

    There is very limited cimetidine data on stage IV CRC, but that data, combined with other stage IV adenocarcinomas treated with cimetidine, speculatively appears very favorable to patients with CA19-9 biomarked (and presumably more so, CSLEX biomarked) tumors.

    My supposition is that longer term cimetidine from day 1 can provide more coverage in low tumor dissemination for stage 4 timewise with less debility and risks for some stage IV patients. If push comes to shove on VEGF-A, we will consider titrating Avastin with cimetidine for some optimum use.

    I seem to be on the Lovenox
    I seem to be on the Lovenox for life plan, so avastin etc. will never be prescribed for me....cimitidine is my only option.
  • pepebcn
    pepebcn Member Posts: 6,331 Member
    #7
    smokeyjoe said:

    I seem to be on the Lovenox
    I seem to be on the Lovenox for life plan, so avastin etc. will never be prescribed for me....cimitidine is my only option.

    After my folfox avastin failure I'm now in xeloda avastin an for
    The moment is working very well!

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