" the Regoranfenib Post & other new drugs"

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Comments

  • pepebcn
    pepebcn Member Posts: 6,331 Member

    Misunderstanding
    I think there has been a misundertanding...if you read starting at the title of the post and continue to the body, you will see that the post you reference is actually very interested in this drug.

    Pamela, l think there are lots of people interested in
    Regoranfenib Here! specially hear about effectiveness and secondary effects so is very important for most of us to know about you!
    By the way have you started ? if so any special effect ?.
    Hugs my friend!
  • Kathryn_in_MN
    Kathryn_in_MN Member Posts: 1,252

    Am I understanding this
    Am I understanding this correctly? Those that got the actuall drug lived approxiamatley a month and a half longer than those that got placebo?

    Understanding trial results
    "The phase 3 trial called CORRECT showed that regorafenib improved survival by a median of 1.4 months, increasing the survival rate from 5 months with placebo to 6.4 months with the drug. Although it represents a small bump in median survival, it’s a 29 percent increase in overall survival in a hard-to-treat patient population."

    Median is NOT average. Median is the middle point of any large scattered data. Understanding trial results gets tricky. This drug is VERY promising. The important thing to look at is the 29% increase in overall survival rate - and this is in people that have failed first-line and second-line treatments. These are people with no hope left at all, not expected to live much longer. And it is helping many of them. Also, think of what it might do if used earlier, which I think it will eventually be licensed for - a first-line treatment, just like Xeloda.

    Those interested should go to the FightCRC.org website and watch last week's webinar with Dr Grothey - very interesting info from the ASCO meeting.
  • janderson1964
    janderson1964 Member Posts: 2,215 Member
    Pamela123 said:

    I'm sorry that my
    I'm sorry that my descriptions are not the most informative and desivive. I dont think i will continue this post due to lack of interest. The comment about "Who would want to take this drug anyway" kinda made that descision for me. Thank you for the help this site has giving me in my times of need.

    Please continue you to
    Please continue you to update us. We are all very interested in this drug.
  • steved
    steved Member Posts: 834

    Please continue you to
    Please continue you to update us. We are all very interested in this drug.

    Have been reading a bit on these lately and thought I would post my interpretation of the data so far:

    Regorafenib (Reg, hear forward to save typing)- is a blocker of VEGF receptor so works in the same pathway as Avastin (which binds VEGF A) aiming to interfere with development of new blood vessels in tumours. The big phase III trial described is certainly significant despite the confusing finding it only increased median survival by 1.4 months. The patient group , as described above, were a very late group who had not responded to all other treatments whose life expectancy was very short. It was extended by almost a third by the drug.In this group almost none (1%) 'responded' ie saw tumour shrinkage, but a good number had their disease stabilised- a good outcome in this group. It needs testing on earlier phases with more data on other end points- quality of life beingone of them. They are also investigating subgroups with the feeling there is a likely group of peoplpe who benefit (bit like the KRAS issue with cetuxamab).

    Aflibercept- is described as a VEGF trap- it binds VEGF A and B and other factors that promote angiogenesis (blood vessel development). It is therefore being promoted as being able to do more than avastin. It too has a phase III trial (VELOUR) in 1226 patients treated with either FOLFIRI with placebo or FOLFIRI with aflibercept. Again survival was improved by about 1.5 months and progression free survival (stable disease period) was increased by 2.2 months. There was also a higher 'response rate' of 19.8% in the treatment group (11.1% in placebo) which is something the Reg study didn't find (though in different patient groups). The side effect profile does concern me though with Aflibercept with high rates of renal problems and hypertension.It is now being studied with FOLFOX.

    Both are very important developments and I think there will be a race to get them approved and find a place in the protocols. They will initially be used late in protocols after others fail but as more studies are done in ealier groups they may move up the algorithms.

    I do think people's experiences with these drugs MUST be reported here as they are invaluable to many of us.If people feel discouraged from doing so it is a huge loss to many of us interested in these drugs. They are truly the first big developments since avastin in a field that has been quiet for too long. For many of us they offer hope- that is vital.

    steve
  • peterz54
    peterz54 Member Posts: 341
    Trial Results
    This articles mentions a 1.4 month overall survival gain for people who did not fair well on first line

    Trial Article at Medpedia
  • smokeyjoe
    smokeyjoe Member Posts: 1,425
    peterz54 said:

    Trial Results
    This articles mentions a 1.4 month overall survival gain for people who did not fair well on first line

    Trial Article at Medpedia

    Pamela...just wondering how
    Pamela...just wondering how you are doing on the trial drug so far?? From you're posts I'm thinking that you've had a weeks worth of the drug and I'm wonding if you're having any side effects etc. Hope it's going very well for you.
  • Pamela123
    Pamela123 Member Posts: 12
    smokeyjoe said:

    Pamela...just wondering how
    Pamela...just wondering how you are doing on the trial drug so far?? From you're posts I'm thinking that you've had a weeks worth of the drug and I'm wonding if you're having any side effects etc. Hope it's going very well for you.

    I think I should start over
    I think I should start over with my description of the drug trial for regoranfenib. I was dx with stage 2 cancer 5/2010. recurrance stage 4 4/2011and 5/2-12. I've had 3 surgeries for colon resections, radiation and i've tried all the drugs zeloda, oxiplatin, iranatecon, avastin. After my last surgery, this drug trial was recommended by my Onc. My Onc said the drug is known for stablizing and stopping growth, they are not sure yet about shrinkage, happens in some. But even no growth or stable is great to hear too. maybe this drug will lead to something that will cure.

    I started on the drugs two weeks ago in Michigan. the drugs is taken with food, and lots of water. Four tablets every morning for 3 weeks on and than 1 week off. Blood is drawn and urine is taken weekly for the first 6 weeks, dr visits everyother week, ct scan every 2 months.

    It is very weird not to have to go to the infussion center, get hookedup and after spending the whole day there, then taking home the pump. It gives a little bit of freedom and better life, as the other drugs took away feeling good.

    The only side effects I have sofar (knock on wood) is a little fatigue, some foods taste a little different. Some effects they said to watch for are the usually suspects.


    I will keep you posted on the progress. Thanks
  • smokeyjoe
    smokeyjoe Member Posts: 1,425
    Pamela123 said:

    I think I should start over
    I think I should start over with my description of the drug trial for regoranfenib. I was dx with stage 2 cancer 5/2010. recurrance stage 4 4/2011and 5/2-12. I've had 3 surgeries for colon resections, radiation and i've tried all the drugs zeloda, oxiplatin, iranatecon, avastin. After my last surgery, this drug trial was recommended by my Onc. My Onc said the drug is known for stablizing and stopping growth, they are not sure yet about shrinkage, happens in some. But even no growth or stable is great to hear too. maybe this drug will lead to something that will cure.

    I started on the drugs two weeks ago in Michigan. the drugs is taken with food, and lots of water. Four tablets every morning for 3 weeks on and than 1 week off. Blood is drawn and urine is taken weekly for the first 6 weeks, dr visits everyother week, ct scan every 2 months.

    It is very weird not to have to go to the infussion center, get hookedup and after spending the whole day there, then taking home the pump. It gives a little bit of freedom and better life, as the other drugs took away feeling good.

    The only side effects I have sofar (knock on wood) is a little fatigue, some foods taste a little different. Some effects they said to watch for are the usually suspects.


    I will keep you posted on the progress. Thanks

    Yeah, infusion and chemo
    Yeah, infusion and chemo pump sucks.....if someone told me I could pop chemo. pills over infusions I would do that ANYDAY!!! Thank you so much for the update :) Keep us posted how it's going. You are our pioneer on this drug.
  • pepebcn
    pepebcn Member Posts: 6,331 Member
    steved said:

    Have been reading a bit on these lately and thought I would post my interpretation of the data so far:

    Regorafenib (Reg, hear forward to save typing)- is a blocker of VEGF receptor so works in the same pathway as Avastin (which binds VEGF A) aiming to interfere with development of new blood vessels in tumours. The big phase III trial described is certainly significant despite the confusing finding it only increased median survival by 1.4 months. The patient group , as described above, were a very late group who had not responded to all other treatments whose life expectancy was very short. It was extended by almost a third by the drug.In this group almost none (1%) 'responded' ie saw tumour shrinkage, but a good number had their disease stabilised- a good outcome in this group. It needs testing on earlier phases with more data on other end points- quality of life beingone of them. They are also investigating subgroups with the feeling there is a likely group of peoplpe who benefit (bit like the KRAS issue with cetuxamab).

    Aflibercept- is described as a VEGF trap- it binds VEGF A and B and other factors that promote angiogenesis (blood vessel development). It is therefore being promoted as being able to do more than avastin. It too has a phase III trial (VELOUR) in 1226 patients treated with either FOLFIRI with placebo or FOLFIRI with aflibercept. Again survival was improved by about 1.5 months and progression free survival (stable disease period) was increased by 2.2 months. There was also a higher 'response rate' of 19.8% in the treatment group (11.1% in placebo) which is something the Reg study didn't find (though in different patient groups). The side effect profile does concern me though with Aflibercept with high rates of renal problems and hypertension.It is now being studied with FOLFOX.

    Both are very important developments and I think there will be a race to get them approved and find a place in the protocols. They will initially be used late in protocols after others fail but as more studies are done in ealier groups they may move up the algorithms.

    I do think people's experiences with these drugs MUST be reported here as they are invaluable to many of us.If people feel discouraged from doing so it is a huge loss to many of us interested in these drugs. They are truly the first big developments since avastin in a field that has been quiet for too long. For many of us they offer hope- that is vital.

    steve

    Steve , afilbercept is available here!
    just notice it in case you r interested!.
    hugs.
  • Bear23
    Bear23 Member Posts: 84
    Pamela123 said:

    I think I should start over
    I think I should start over with my description of the drug trial for regoranfenib. I was dx with stage 2 cancer 5/2010. recurrance stage 4 4/2011and 5/2-12. I've had 3 surgeries for colon resections, radiation and i've tried all the drugs zeloda, oxiplatin, iranatecon, avastin. After my last surgery, this drug trial was recommended by my Onc. My Onc said the drug is known for stablizing and stopping growth, they are not sure yet about shrinkage, happens in some. But even no growth or stable is great to hear too. maybe this drug will lead to something that will cure.

    I started on the drugs two weeks ago in Michigan. the drugs is taken with food, and lots of water. Four tablets every morning for 3 weeks on and than 1 week off. Blood is drawn and urine is taken weekly for the first 6 weeks, dr visits everyother week, ct scan every 2 months.

    It is very weird not to have to go to the infussion center, get hookedup and after spending the whole day there, then taking home the pump. It gives a little bit of freedom and better life, as the other drugs took away feeling good.

    The only side effects I have sofar (knock on wood) is a little fatigue, some foods taste a little different. Some effects they said to watch for are the usually suspects.


    I will keep you posted on the progress. Thanks

    I am in the process of
    I am in the process of trying to get into the Aventura site. It really is amazing that there are no sites in New England. Aventura has not started dispensing the meds yet, about another week. My files have been faxed down and we are awaiting a reply. I would be number 5 on the wait list. However I just stopped Xelox on Friday and would need to wait 4 weeks before starting anyways. If I don't get my lung tumors to stop growing, I was told I have about 6 months. I have been on Folfox, 5 fu and avastin, Irinotecan and Vectibix, Xelox and avastin. I have not tried Mitomycin.

    I agree that we need to keep talking and posting about what is going on with Regorafinib and other drugs. It gives us some hope that maybe, even though we are stage 4, there is something to help. Please keep posting Pam.

    Valerie
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900
    Bear23 said:

    I am in the process of
    I am in the process of trying to get into the Aventura site. It really is amazing that there are no sites in New England. Aventura has not started dispensing the meds yet, about another week. My files have been faxed down and we are awaiting a reply. I would be number 5 on the wait list. However I just stopped Xelox on Friday and would need to wait 4 weeks before starting anyways. If I don't get my lung tumors to stop growing, I was told I have about 6 months. I have been on Folfox, 5 fu and avastin, Irinotecan and Vectibix, Xelox and avastin. I have not tried Mitomycin.

    I agree that we need to keep talking and posting about what is going on with Regorafinib and other drugs. It gives us some hope that maybe, even though we are stage 4, there is something to help. Please keep posting Pam.

    Valerie

    this is a great thread
    I hope this and any other drugs can help.
    Really huge hugs for you all and my prayers,

    Hugs,
    Pete

    Ps I am not on chemo and my focus is natural health but if any drug new or old offers hope then I pray it delivers.
  • peterz54
    peterz54 Member Posts: 341
    for mCRC
    I just read an article in press for Clinical Colorectal Cancer

    Survival Outcomes of Bevacizumab Beyond
    Progression in Metastatic Colorectal Cancer
    Patients Treated in US Community Oncology - T. Cartwright

    it indicates that mCRC patients who have completed their first line therapy and then take Bevacizumab (Avastin) beyond progression have a 6 month advantage in overall survival versus those that did not take Bevacizumab
  • steved
    steved Member Posts: 834
    peterz54 said:

    for mCRC
    I just read an article in press for Clinical Colorectal Cancer

    Survival Outcomes of Bevacizumab Beyond
    Progression in Metastatic Colorectal Cancer
    Patients Treated in US Community Oncology - T. Cartwright

    it indicates that mCRC patients who have completed their first line therapy and then take Bevacizumab (Avastin) beyond progression have a 6 month advantage in overall survival versus those that did not take Bevacizumab

    Interesting
    Thanks for this- can only find abstracts of the article online- do you have access to the full article {(if so can you put a link or perhaps send it as a PM for me to read through- prefer to make a judgement of the value of the data only after seeing the full article).

    If I understand right the suggestion is that if you are on avastin and your cancer progresses you do still do better if you stay on Avastin (6 months longer survival overall, but only 4 onths better if measured from teh point where your cancer is deemed to have still progressed) than if you come off it. This is important as often doctors response to cancer progression on chemo is to stop or change that chemo and in the case of avastin that may not be the best thing. :It suggests, even in progressing cancer blocking VEGF slows the overall rate to death in CRC.

    Worth making your docs aware of this if you are in this position but also on a personal level it doesn't address the issues of quality of life on and off avastin- only measures time till death as the end point.

    steve
  • manwithnoname
    manwithnoname Member Posts: 402
    smokeyjoe said:

    Yeah, infusion and chemo
    Yeah, infusion and chemo pump sucks.....if someone told me I could pop chemo. pills over infusions I would do that ANYDAY!!! Thank you so much for the update :) Keep us posted how it's going. You are our pioneer on this drug.

    You can pop pills
    Been looking into this, its called Metronomic chemo, meaning low doses orally but for much longer time frames.
    Sometimes these protocols include non-chemo drugs. They can sometimes be much more effective without the side effects.

    We have started this. It is still very new though.
  • peterz54
    peterz54 Member Posts: 341
    steved said:

    Interesting
    Thanks for this- can only find abstracts of the article online- do you have access to the full article {(if so can you put a link or perhaps send it as a PM for me to read through- prefer to make a judgement of the value of the data only after seeing the full article).

    If I understand right the suggestion is that if you are on avastin and your cancer progresses you do still do better if you stay on Avastin (6 months longer survival overall, but only 4 onths better if measured from teh point where your cancer is deemed to have still progressed) than if you come off it. This is important as often doctors response to cancer progression on chemo is to stop or change that chemo and in the case of avastin that may not be the best thing. :It suggests, even in progressing cancer blocking VEGF slows the overall rate to death in CRC.

    Worth making your docs aware of this if you are in this position but also on a personal level it doesn't address the issues of quality of life on and off avastin- only measures time till death as the end point.

    steve

    Link to abstract
    Unable to provide link to artilce as I read it through a subscribers portal

    here is abstract which you probably have seen

    Beyond progression

    you may be able to get full article from one of the authors. or have your ONC follow-up.

    Our ONC intends to keep my wife on Avastin after completion of 1st line and this may be why.


    You may be able to review Grothey's comments about this from about 2008 doing google scholar search.