MDX-1106, part three

foxhd said:

Others
Yes others are doing well. In the earlier phase 1 study some have been off the drug and have had continued response. I was told that one fellow had decided to opt out of the trial because of the committment. The doc reconvinced him to stay and he is now in full recovery.

That sounds great! I wonder
That sounds great! I wonder how long he has been in recovery.

foxhd said:

Getting better.
..OK...now here is the thing....I had my little breakdown. I am over it. Hurray for me!! Now lets hope it is long term. I am no longer a person with cancer. I am someone recovering from cancer.....have to remain positive , right? I mean, it isn't all gone. But going....Now lets focus on taking care of you guys. You better get used to crappy jokes and a weird sense of humor. I am a health care provider, but I'm also a biker so Maybe I can't be trusted. Wait, I'm a golfer, so maybe I lie a little. No wait, I also play guitar. Things can sound pretty good.........In any event.......How yu doin?

I am so happy for you
...Fox - you have been an inspiration to me. And crying....I read this last night and cried...thought about what to say....was so overwhelmed...read it today...and again tears of joy for you. I try for putting myself in another's shoes...but when it comes to a dx like yours....I can not imagine having mets. But then again, I guess my mind might have gone there as a possibility .... and now with you going before everyone with the trial and recovering....recovering from this disease! I have no choice but to noiminate you as the kidney cancer poster boy for courage and bravery and hope. JLY (Jan Loves You.)

j_rod said:

more info on mdx1106
I just found a website on http://www.ackc.org/kidney-cancer-information/asco-2010-reports/mdx-1106-trial/

It is looking promising. Bristol Meyers bought it in 2009. Studies are very promising. They are preparing for phase II. They are recruting - but as the article says, "they are recruiting 50-60 lung cancer patients even though the research in phase one is more promising for RCC." They put in a blurb that "maybe some pressure from the RCC community might increase the number of RCC participants is needed." They also state that the possible reason for the higher number of recruits for lung cancer patients is a greater - maybe I am interpreting this incorrectly - is the urgency/higher profile of the disease of lung cancer. Correct me if I am wrong in my interpretation of the article but that is what I got from it. I already emailed them with my thoughts. How about it folks? How about an email campaign to Bristol Meyers Squid from all of us?

Jan, the strategy behind the recruitment must be primarily driven by considerations of return on investment (in drug research).

The only seriously effective treatment for RCC is surgery (insofar as it's a possible complete cure and nothing else offers that, save in a small %age of cases). Also RCC is far less common than cancers like breast, liver, lung, colorectal all of which have more to gain from drug treatments.

Melanoma is interestingly related to RCC in terms of promising leads for new drugs. The bottom line is that many new ideas which may benefit RCC patients are trialled on the big number cancers first. We don't have to be too cynical either - it's important in trials to have sufficient numbers of subjects to make statistically significant interpretations of results possible and when this can't be achieved quickly in RCC it can be to our benefit if the work is carried out in another malady sooner and, if promising, can then be tried out on RCC.

foxhd said:

trials
I like to think that the MDX trial for kidney cancer was chosen because they anticipated good results. This would make it easier to get through the red tape and to market. Who knows how many cancers this can help. A little change here and there.This drug may have many applications. Someone asked me if I bought stock in the company yet. Then they asked why not?....mmmmmm....

The Fonz...
Would say "EXACTAMUNDO!"

FYI: Bristol is BMY on the NYSE, currently trading at just over $34

Excited!!
I am so happy for your progress. Keep us posted. My son will taking the leap into the IL2 word 6/11. Fingers crossed.

myboys2 said:

Excited!!
I am so happy for your progress. Keep us posted. My son will taking the leap into the IL2 word 6/11. Fingers crossed.

mdx1106
I'm new to this site, but these posts are so inspirational. In 2010 I had left kidney removed but mets where found in lungs in nov 2011. I just finished the il-2 with no help. My next stage in the fight is a trial with mdx 1106 and also an oral. The posts that i have read are uplifting and i sure appreciate them. Good luck and God bless all of you, keep up the good fight!!

foxhd said:

MDX
I stuttered.

Stuttering...
Probably a side effect of MDX, better report it.

foxhd said:

Benefits of MDX
...Here's the thing....I am so fortunate to have the opportunity to be on MDX......Especially since I had been diagnosed with Basal Cell Ca also a couple weeks ago. The good news is the medication has reduced the lesion and sugery has eliminated it. But today, I also find that I have melanoma....sheesh....Now to see another oncologist, have it removed and await for what's next....I have most of June and early July booked for motorcycle trips. Just can't avoid the sun. I hope the MDX keeps on working.....

One stone two birds
As far as I know, MDX works on melanoma as well. So, there you go...

Jon