Method to predict your response to Cetuximab/Erbitux?

coloCan
coloCan Member Posts: 1,944 Member
edited January 2012 in Colorectal Cancer #1
reuters.com/article/2012/idUS116929+20-Jan-2012+HUG20120120

(Warning:the above is a press release)

Much more should be coming from this ASCO Gastro meeting



Also, new type of CT requiring considerable less radiation:

newswise.com/articles/view/584868/?sc=dwhn

Comments

  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #2
    steve you are a legend
    a few good things out of germany. i got to go for a holiday, and soon!!!!!!!!!

    all three of my onc's are at asco, i wonder if they will have different perspectives for me, onc 1 and onc3 are back 23rd. they will be jet lagged.

    and its great that you posted this, i am having this same issue
    about ct scans and radiation with my hospital.
    http://petertrayhurn.blogspot.com/2012/01/ken-seles-help-needed.html

    thanks,
    Pete
  • coloCan
    coloCan Member Posts: 1,944 Member
    #3
    pete43lost_at_sea said:

    steve you are a legend
    a few good things out of germany. i got to go for a holiday, and soon!!!!!!!!!

    all three of my onc's are at asco, i wonder if they will have different perspectives for me, onc 1 and onc3 are back 23rd. they will be jet lagged.

    and its great that you posted this, i am having this same issue
    about ct scans and radiation with my hospital.
    http://petertrayhurn.blogspot.com/2012/01/ken-seles-help-needed.html

    thanks,
    Pete

    If your oncs are like mine, they tend to rely upon what current
    ASCO policy is in treating our specific type(s) of tumor. I used to bring mine copies of items i printed off internet that mentioned genes/proteins/pathways,etc that some research team somewhere came across and she, my onc, would try to explain how much more needed to be done before it directly influenced treatments..Most oncs, for a variety of reasons, are not that versed in alernative/complementary treatments neither.....But i think all of us to do what each feels must be done ......steve

    PS: as we all know, no one country or region of this planet has a monooply on cancer research
  • coloCan
    coloCan Member Posts: 1,944 Member
    #4
    pete43lost_at_sea said:

    steve you are a legend
    a few good things out of germany. i got to go for a holiday, and soon!!!!!!!!!

    all three of my onc's are at asco, i wonder if they will have different perspectives for me, onc 1 and onc3 are back 23rd. they will be jet lagged.

    and its great that you posted this, i am having this same issue
    about ct scans and radiation with my hospital.
    http://petertrayhurn.blogspot.com/2012/01/ken-seles-help-needed.html

    thanks,
    Pete

    as long as this duplicated,might as well toss out some more
    stuff some might be interested in, such as testing for circulating tumor cells:

    clinicaloncology.com/View/Article.aspx?d=Solid+Tumors&id=148&i=January+2012&i_id=808&a_id=
    20044

    Also on CTCs:sciencedaily.com/releases/2012/01/120116095535.htm

    and something called Pericytes:ivanhoe.com/channels/p_printStory.cfm?storyid=28764

    nanowerk.com/newsid=( now type in any one of these for an article on nano and cancer)
    23808.php
    24007.php
    24006.php
    24011.php
    23754.php
  • PhillieG
    PhillieG Member Posts: 4,866 Member
    #5
    Well...
    If it's anything like how they predict the weather I think they should stick with putting their hand outside and see if it comes back wet, dry, cold, hot, or not at all.
    So does this "prediction" mean that if insurance companies deem you unworthy of the drugs due to a "prediction", you won't be able to use the meds (or YOU have to pay for them)? To me, using the words "cancer" & "prediction" is not how this disease should be handled. Also, what if they "predict" that you will do well and you don't? Can you sue?

    It's an interesting article Steve, thanks for posting it.
    Food for thought
    ;-)
    -p
  • coloCan
    coloCan Member Posts: 1,944 Member
    #6
    PhillieG said:

    Well...
    If it's anything like how they predict the weather I think they should stick with putting their hand outside and see if it comes back wet, dry, cold, hot, or not at all.
    So does this "prediction" mean that if insurance companies deem you unworthy of the drugs due to a "prediction", you won't be able to use the meds (or YOU have to pay for them)? To me, using the words "cancer" & "prediction" is not how this disease should be handled. Also, what if they "predict" that you will do well and you don't? Can you sue?

    It's an interesting article Steve, thanks for posting it.
    Food for thought
    ;-)
    -p

    Here's something else i just read on effectiveness of oxi:
    http://ecancer.org/news/2348

    "Study showed oxaliplatin improved colon cancer patient survival" in stage IIIers who did adjuvant Tx that added oxi to 5FU
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #7
    CT radiation reduction
    GE's Veo is an intensive computation CT software package that uses data more efficiently to reduce radiation exposure, perhaps 96-98% according to the news release. Personally, I would be more interested in reducing the radiation of recent vintage CT machines, say 50%-67%, and get better images. It will be interesting to see whether licensing or similar research allows these improvements in other brand CTs (e.g. Phillips, Siemens, Toshiba).
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #8
    coloCan said:

    Here's something else i just read on effectiveness of oxi:
    http://ecancer.org/news/2348

    "Study showed oxaliplatin improved colon cancer patient survival" in stage IIIers who did adjuvant Tx that added oxi to 5FU

    improvements always welcome?
    Question is, are there treatments that outperform oxaliplatin at stage III CC for lower cost, lower toxicity, for radically better outcomes by years? The non-American data strongly suggest "yes" for cimetidine+ oral UFT (+LV) + PSK for 65-70% of stage III patients (without biomarkers), and 90+% for those with biomarkers measured positive.
    * Note UFT, a generic oral 5FU prodrug with a powerful HIF-1a inhibitor (important molecular target), is not yet available in the US, Australia, Canada (UFT is approved in UK) and some of the least developed countries.
  • coloCan
    coloCan Member Posts: 1,944 Member
    #9
    tanstaafl said:

    CT radiation reduction
    GE's Veo is an intensive computation CT software package that uses data more efficiently to reduce radiation exposure, perhaps 96-98% according to the news release. Personally, I would be more interested in reducing the radiation of recent vintage CT machines, say 50%-67%, and get better images. It will be interesting to see whether licensing or similar research allows these improvements in other brand CTs (e.g. Phillips, Siemens, Toshiba).

    New article on resistance to Cetuximab just issued at,among
    other sites:medicalxpress.com/news/2012-01-resistance-colon-cancer-treatment.html

    as well as one on how inflammation can kead to CRC:medicalxpress.com/print246455346.html

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