i am going nuts, walnuts that is. so is VITAMIN E best from natural sources ? I think yes and sulpho

pete43lost_at_sea · December 2011

i am going nuts, walnuts that is. so is VITAMIN E best from natural sources ? I think yes and sulphorane, lef oncologist

the cancer defeated article says vitamin e all the types is good for health and offers a warning that the cheap vitamin e is not good for you. sounded reasonable to me, so i have ordered the more expensive vitamin e and am having more nuts in my diet.

looking for anyone critic of this with regard cancer, its not specifically colorectal, but apart of the attaining health goal i have set for myself.

even though i am trying lots of supplements and foods, most have some science behind them, now it may not be accepted. often when i float these things i am trying in public i am seeking feedback about your evaluation of the link and its facts, credibility etc etc.

the nuts title is supposed to be funny, but so far no bites.

walnuts and many nuts are the best source of this essential vitamin e, to the best of my understading.

many of you would say, i am already nuts. well don't get my diet and state of mind confused.

cancer defeated is an interesting site, i wil check it out more.

the vit e stuff was recommended by my integrative gp.

http://cancerdefeatedpublications.com/newsletters/The-WRONG-kind-of-vitamin-E.html

http://petertrayhurn.blogspot.com/2011/12/cancer-defeated-thankyou-ashley-vitamin.html

my integrative gp ashley suggested cancer defeated, its shared here in good faith. if you don't like it, don't read it, i am also interested in your assessment of it.

its got all the back issues online, for free. i presume its got a somewhat non mainstream approach but that said, at least its a source of info.

i also had a warning about not over doing vitamin c orally, whose method of action is different to the iv i get. too many antioxidants can disable some cell signaling pathsways. i spoke to a sulphorane researcher about this, who is just about publish an article on sulphorane and cancer. if i get the draft i will share it, no point holding onto the info. its a natural supplement basically a superfood thats been put into capsules. its replacing the broccoli sprouts i have been trying to grow and the broccoli sprouts i have buying to eat. this powdered supplement is supposed to more bio available and the foods. its also specifically indicated for colorectal cancers as the active ingredients comes into direct contact with our tumours if they are present in the gi track. i have not seen the study but it was describes and makes sense.

I had another call from the lef (life extension foundation) oncologist today, we discussed the specifics of every supplement, dosages, timings and general advice. great service from lef. i buy most of the supplements from iherb, lef does many some excellent quality products supplements and research. i read the new magazine cover to cover today. could not put it down. nothing exceptional for colorectal except coffee maybe

The key points is to move liver health to evening.
To take immune system assists evening as sleep is when your immune system works. this makes lots of sense but i have not researched this yet.
to take my premeal digestive aides ie alovera, enzymes, slippery eln and gut relief 30 min before meals. this should aide absorption food nutrients and supplements into the blood stream.
got some advice to get my homocystiene down from 11 to under 8 which is anticancer target.
finally got commonsense advice about spacing out my supplements more evenly to ensure they are in my blood supply for an extended period of time. so i am reducing my morning and evening supplements and adding in a lunch time dosaging. i am getting advice from the supplement cancer experts i feel, so i am implementing.
when my regime settles down i will document it. still learning to much each day about nutrition and cancer and effectively managing nutrition and supplements for maximum effect and minimum impact on lifestyle.

finally i relayed the positive news about cimetidine from yesterday onc consultation and the molecular cancer review and sent him my test results just for fun. i discussed the potential short comings of the rgcc molecular test.

this is almost the end of the medical appointments and now i can relax till 23 jan for the next cea, actually i got an unofficial cea on the 7th as a check point.

finally took the kids with me to do a live blood anaylsis, we also saw my red blood cells, white blood cells including neutrolphils, lymphocytes. greg my nauturopath friend and advisor did it as an xmass present, get timing. i needed a lift, he said my blood looked perfect. now i have a mental picture of what exactly my lymphocytes look like, i use this imagery when i am visualising healing and meditating. lots of action and movement in the blood. gregs best advice was to settle down, relax, sleep ( help your immune system ) i told him i have been struggling with balancing research, treatment with diet, rest, sleep and exercise. his care is exceptional.

this is just my journey, sharing in case its of interest. i have been priviliged to meet lots of caring, clever and kind specialists.

i know the expression here is poor, but if i don't get it recorded as i experience it, i will never do it tomorrow.

hugs,
pete

pete43lost_at_sea · December 2011

alas my humour misses the mark again, nethertheless
http://www.lef.org/magazine/mag2011/jan2011_Critical-Importance-of-Gamma-E-Tocopherol-Continues-to-Be-Overlooked_01.htm

Anti-Cancer Effects

Just as we saw with cardiovascular disease, gamma tocopherol exerts anti-cancer effects through a variety of important mechanisms, giving it an especially broad spectrum of action against a host of tumor types. At the very beginning of the cancer development process, gamma tocopherol traps reactive nitrogen species and other free radicals that cause mutations in DNA strands and render cells vulnerable to malignant transformation.18,19 This is a crucial step in the prevention of cancer.

Gamma tocopherol inhibits cancer cell growth in culture through a number of different mechanisms.20 It down-regulates control molecules known as cyclins, which trap cancer cells in the midst of their reproduction cycle and prevent them from reproducing and spreading.21 This anti-cancer effect appears to be based on a mechanism separate from the vitamin’s well-known antioxidant powers.

A cell membrane receptor called PPAR-gamma is a promising target for anticancer therapies because it affects genes that control cancer cell growth and death.22 This is why PPAR-activating drugs are being researched and developed by pharmaceutical companies as anti-cancer drugs. Gamma tocopherol is more powerful than alpha tocopherol at stimulating PPAR-gamma activity, especially in colon cancer cells.23,24 In prostate cancer cells, PPAR-gamma stimulation by gamma tocopherol resulted in a complete cessation of cancer cell growth.24

WHAT YOU NEED TO KNOW: GAMMA E
Emerging data reveal that gamma tocopherol supplies potent protection against cardiovascular disease, cancer, and even neurodegenerative conditions.
Gamma tocopherol has superior anti-inflammatory and gene regulatory activities, while alpha-tocopherol remains a potent antioxidant.
Once cancerous transformation has taken place, there are still biological opportunities to prevent full-blown tumor development. One of these ways is the induction of deliberate cell death through built-in genetic programs, a process called apoptosis. In a variety of cancer tissues, gamma tocopherol has been found to be superior to alpha tocopherol at inducing apoptosis, triggering a number of cell-death-inducing pathways.25,26 In prostate cancer cells, gamma tocopherol induced cell death by blocking synthesis of important cell membrane components.27 And gamma tocopherol also reduces the development of new blood vessel formation in tumors, depriving them of the nutrients they need to thrive.28

To date, all of these mechanisms have been shown to inhibit cancers of the colon, prostate, breast, and lung in animal models, with many more under active investigation.29

Human studies provide excellent confirmation of the unique chemoprotective effects of gamma tocopherol. A diet rich in walnuts, which contain gamma tocopherol (3 oz. contain 15.6 mg gamma tocopherol), produced a trend towards improvement in measurements of prostate-specific antigen (PSA)—a marker of prostate cancer.30 Note that one would have to eat massive amounts of walnuts each day (almost 2.5 pounds) to obtain optimal gamma tocopherol dosing. This is why supplementation with gamma tocopherol is an important component of any prevention program.

I am waiting for my gamma tocopherol order to come in.

tanstaafl · December 2011

pete43lost_at_sea said:
alas my humour misses the mark again, nethertheless
http://www.lef.org/magazine/mag2011/jan2011_Critical-Importance-of-Gamma-E-Tocopherol-Continues-to-Be-Overlooked_01.htm

Anti-Cancer Effects

Just as we saw with cardiovascular disease, gamma tocopherol exerts anti-cancer effects through a variety of important mechanisms, giving it an especially broad spectrum of action against a host of tumor types. At the very beginning of the cancer development process, gamma tocopherol traps reactive nitrogen species and other free radicals that cause mutations in DNA strands and render cells vulnerable to malignant transformation.18,19 This is a crucial step in the prevention of cancer.

Gamma tocopherol inhibits cancer cell growth in culture through a number of different mechanisms.20 It down-regulates control molecules known as cyclins, which trap cancer cells in the midst of their reproduction cycle and prevent them from reproducing and spreading.21 This anti-cancer effect appears to be based on a mechanism separate from the vitamin’s well-known antioxidant powers.

A cell membrane receptor called PPAR-gamma is a promising target for anticancer therapies because it affects genes that control cancer cell growth and death.22 This is why PPAR-activating drugs are being researched and developed by pharmaceutical companies as anti-cancer drugs. Gamma tocopherol is more powerful than alpha tocopherol at stimulating PPAR-gamma activity, especially in colon cancer cells.23,24 In prostate cancer cells, PPAR-gamma stimulation by gamma tocopherol resulted in a complete cessation of cancer cell growth.24

WHAT YOU NEED TO KNOW: GAMMA E
Emerging data reveal that gamma tocopherol supplies potent protection against cardiovascular disease, cancer, and even neurodegenerative conditions.
Gamma tocopherol has superior anti-inflammatory and gene regulatory activities, while alpha-tocopherol remains a potent antioxidant.
Once cancerous transformation has taken place, there are still biological opportunities to prevent full-blown tumor development. One of these ways is the induction of deliberate cell death through built-in genetic programs, a process called apoptosis. In a variety of cancer tissues, gamma tocopherol has been found to be superior to alpha tocopherol at inducing apoptosis, triggering a number of cell-death-inducing pathways.25,26 In prostate cancer cells, gamma tocopherol induced cell death by blocking synthesis of important cell membrane components.27 And gamma tocopherol also reduces the development of new blood vessel formation in tumors, depriving them of the nutrients they need to thrive.28

To date, all of these mechanisms have been shown to inhibit cancers of the colon, prostate, breast, and lung in animal models, with many more under active investigation.29

Human studies provide excellent confirmation of the unique chemoprotective effects of gamma tocopherol. A diet rich in walnuts, which contain gamma tocopherol (3 oz. contain 15.6 mg gamma tocopherol), produced a trend towards improvement in measurements of prostate-specific antigen (PSA)—a marker of prostate cancer.30 Note that one would have to eat massive amounts of walnuts each day (almost 2.5 pounds) to obtain optimal gamma tocopherol dosing. This is why supplementation with gamma tocopherol is an important component of any prevention program.

I am waiting for my gamma tocopherol order to come in.

delta tocotrienol
We use high gamma tocopherols as an antinflammatory and some alpha tocopheryl succinate. AFAIK, the most interesting anti-cancer claims are the delta tocotrienol vitamer, the last of the 8 vitamin E isomers, most unlike alpha tocopherol. No experience here, but there are interesting claims and pharmaceutical lab data from a patent. Might look up "Delta Gold".

pete43lost_at_sea · December 2011

tanstaafl said:
delta tocotrienol
We use high gamma tocopherols as an antinflammatory and some alpha tocopheryl succinate. AFAIK, the most interesting anti-cancer claims are the delta tocotrienol vitamer, the last of the 8 vitamin E isomers, most unlike alpha tocopherol. No experience here, but there are interesting claims and pharmaceutical lab data from a patent. Might look up "Delta Gold".

i have got most of my supplement mix locked down
almost finsished updating it, i will put it on my blog.

an amazing day, today. had the big meeting with integrative gp with wife while getting iv c.

they added iv zinc and a sub cutaneous b12 just for fun.

that was supposed to help boost the immune system and lower my homocysteine.

if this stupid cea is showing an active cancer then if it waits i will give it the healthiest body to have a fight with.

i don't like its chances. getting my k3 tomrrow, at last yippee.

hugs,
Pete

ps have you looked over this lef summary its good, a few old but interesting cases thats the basis of their colorectal protocols i suspect.
http://www.lef.org/protocols/abstracts/abstr-148.html?source=search&key=colorectal
anyone who takes the time to read this post may be rewarded if they checkout the link above.

tanstaafl · December 2011

pete43lost_at_sea said:
i have got most of my supplement mix locked down
almost finsished updating it, i will put it on my blog.

an amazing day, today. had the big meeting with integrative gp with wife while getting iv c.

they added iv zinc and a sub cutaneous b12 just for fun.

that was supposed to help boost the immune system and lower my homocysteine.

if this stupid cea is showing an active cancer then if it waits i will give it the healthiest body to have a fight with.

i don't like its chances. getting my k3 tomrrow, at last yippee.

hugs,
Pete

ps have you looked over this lef summary its good, a few old but interesting cases thats the basis of their colorectal protocols i suspect.
http://www.lef.org/protocols/abstracts/abstr-148.html?source=search&key=colorectal
anyone who takes the time to read this post may be rewarded if they checkout the link above.

good link
Its a good link to relevant abstracts.

janie1 · December 2011

pete43lost_at_sea said:
i have got most of my supplement mix locked down
almost finsished updating it, i will put it on my blog.

an amazing day, today. had the big meeting with integrative gp with wife while getting iv c.

they added iv zinc and a sub cutaneous b12 just for fun.

that was supposed to help boost the immune system and lower my homocysteine.

if this stupid cea is showing an active cancer then if it waits i will give it the healthiest body to have a fight with.

i don't like its chances. getting my k3 tomrrow, at last yippee.

hugs,
Pete

ps have you looked over this lef summary its good, a few old but interesting cases thats the basis of their colorectal protocols i suspect.
http://www.lef.org/protocols/abstracts/abstr-148.html?source=search&key=colorectal
anyone who takes the time to read this post may be rewarded if they checkout the link above.

Hey Pete. Interesting stuff
Hey Pete. Interesting stuff always. I wanted to ask how often do you blood tests, I guess particularly INR, to check clotting. If you take a lot of gamma E, tumeric, etc., is it important to check that? Do you have one main doctor that goes over all the supplements and then
Keeps track of blood chemistries? I wasn't sure if you have to carefully watch the cumulative blood-thinning issues from the various supplements, or if there are even any. Hope that makes sense.

pete43lost_at_sea · December 2011

janie1 said:
Hey Pete. Interesting stuff
Hey Pete. Interesting stuff always. I wanted to ask how often do you blood tests, I guess particularly INR, to check clotting. If you take a lot of gamma E, tumeric, etc., is it important to check that? Do you have one main doctor that goes over all the supplements and then
Keeps track of blood chemistries? I wasn't sure if you have to carefully watch the cumulative blood-thinning issues from the various supplements, or if there are even any. Hope that makes sense.

thanks janie
i played with inr myself and it was fine.

i want to kill these cancer cells before chemo, my blood might get a little thinner.

doing bloods monthly as, more tests and markers keep popping up, just realised i want to measure my selenium. checkout the blog , i have gone half way through the lef clinical study summaries.

i have been on the right track for this year, tese studies are the proof i need, now i just have to implement the advice and pray.

i have a great integrative gp, i actually have three of them, they all have a piece of the puzzle. they are not colorectal gurus yet, give them another few months.

you got to like this one. even my int gp does know about these studies, he is working off first principles, but he is absolutely fantastic as he points me in the right direction.

Development of gamma (gamma)-tocopherol as a colorectal cancer chemopreventive agent.
Campbell S, Stone W, Whaley S, et al.
Crit Rev Oncol Hematol. 2003 Sep; 47(3):249-59.
Nutritional factors play an important role in the prevention and promotion of colorectal cancer. Vitamin E is a generic term that describes a group of lipid-soluble chain-breaking antioxidants that includes tocopherols and tocotrienols. Vitamin E occurs in nature as eight structurally related forms that include four tocopherols and four tocotrienols. Vitamin E is a potent membrane-soluble antioxidant. Antioxidants like vitamin E (tocopherols) may prevent colon cancer through several different cellular and molecular mechanisms. Vitamin E in the American diet is primarily available in plant-oil rich foods such as vegetable oils, seeds and nuts and these foods vary widely in their content of alpha-tocopherol and gamma-tocopherol. Vitamin E may help prevent colon cancer by decreasing the formation of mutagens arising from the oxidation of fecal lipids, by decreasing oxidative stress in the epithelial cells of the colon and by molecular mechanisms that influence cell death, cell cycle and transcriptional events. Most epidemiological, experimental and clinical studies have evaluated the alpha-isoform and not the gamma-isoform of vitamin E. Recent epidemiological, experimental and mechanistic evidence suggests that gamma-tocopherol may be a more potent cancer chemopreventive agent than alpha-tocopherol. The differences in chemical reactivity, metabolism and biological activity may contribute to these differences in the effects of gamma-tocopherol when compared with alpha-tocopherol. The rationale supporting the development of gamma-tocopherol as a colorectal cancer preventive agent is reviewed here

Thank god i am on the lef super booster soft gel and the tocotrienols. i wonder if ashley realised how his general advise relates specifically to colorectal.

you know janie, thanks for replying, the only one besides tanstafl, i wonder why i post this health sometimes, so few hits. i wonder if this is a crc board, we can do so much more than we are.

just hugs,
pete

ps be well!!!!!!!!!!

i am going nuts, walnuts that is. so is VITAMIN E best from natural sources ? I think yes and sulpho

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