Treatment with Nexavar, how real?

Olgs
Olgs Member Posts: 10
in Liver Cancer #1
I'm looking for some additional information on liver cancer treatment with Nexavar. As I understand it is quite popular in US as a target drug for liver malignancies. We live in Russia where it is approved yet, but it is possible to participate in clinical trials.

My father has been diagnosed with HCC 15 months ago when his not so large tumor started bleeding. It was horrible as he has lost over 2 liters of blood. We were told that in case of the bleeding tumor chances are much much lover, even though the tumor was really small. Since then he had undergone another surgery to remove part of the liver, several chemo embolizations with various drugs and even specially prepared medicines that we receive from Tibet. But cancer is very persistant. AFP levels rise, new smaller tumors appear in the right lobe (left is totally clean) and although they are immediately killed by new chemo treatments there seems no end to this. It is a difficult and painful game. The only good thing is that my dad feels really well, he is active - working, travelling, taking all treatment very lightly.

But I understand that there should be some additional system treatment. That's why I'm trying to find info on Nexavar. How does it work? Does it help? And what are side effects? I want to hear smth from real people not from the web page of a pharmaceutical company. I would really appreciate some advise.

Comments

  • slg
    slg Member Posts: 200
    #2
    Nexaver
    Hi Olgs,

    I was hoping someone would have commented on this subject by now so I guess I'm it. If you can find my previous posts you will find out more about Nexavar. Yes, there are side effects but for the most part there are solutions/remedies and some even do subside.

    If you need more info feel free to email me at slg72@aol.com.
  • march00
    march00 Member Posts: 20
    #3
    Nexavar
    I just had a huge turmor removed from the left lobe, my
    surgeon said he got it all out and I currently not on any meds, However I spoke with a Heptologist and he thought that I should be on Nexavar.

    Its great that the disease is cured by the treatments, from what I
    have read I myself think that Nexavar is for inoperable liver cancer, in the final
    stages it can give your a couple more months

    Nick
  • Olgs
    Olgs Member Posts: 10
    #4
    slg said:

    Nexaver
    Hi Olgs,

    I was hoping someone would have commented on this subject by now so I guess I'm it. If you can find my previous posts you will find out more about Nexavar. Yes, there are side effects but for the most part there are solutions/remedies and some even do subside.

    If you need more info feel free to email me at slg72@aol.com.

    Thank you for your post, I
    Thank you for your post, I will read your previous comments!
  • Olgs
    Olgs Member Posts: 10
    #5
    march00 said:

    Nexavar
    I just had a huge turmor removed from the left lobe, my
    surgeon said he got it all out and I currently not on any meds, However I spoke with a Heptologist and he thought that I should be on Nexavar.

    Its great that the disease is cured by the treatments, from what I
    have read I myself think that Nexavar is for inoperable liver cancer, in the final
    stages it can give your a couple more months

    Nick

    That's smth I've heard
    That's smth I've heard before, that it is a drug of hope for those that are not eligible for any other type of treatment and that it is aimed at prolonging life. But There are opinions that it could be used as treatment in combination with other methods. That's what I'm trying to find out!
    My dad is still having chemo embolization procedures but unfortunately his AFP levels grow. That's why we are looking into all types of therapies!
  • offunspirit
    offunspirit Member Posts: 8
    #6
    Olgs said:

    That's smth I've heard
    That's smth I've heard before, that it is a drug of hope for those that are not eligible for any other type of treatment and that it is aimed at prolonging life. But There are opinions that it could be used as treatment in combination with other methods. That's what I'm trying to find out!
    My dad is still having chemo embolization procedures but unfortunately his AFP levels grow. That's why we are looking into all types of therapies!

    My husband is in a clinical
    My husband is in a clinical trial for sorafenib (Nexavar) at Johns Hopkins in Baltimore, MD. He had the TACE, chemoembolization treatment, in November and is also taking sorafenib (Nexavar)as a combination treatment. From my understanding, the simple explanation is chemoembolization will kill the cancer cells within the tumor and sorafenib is suppose to keep new blood vessels from forming that could become new tumors. The MRI in December shows the TACE procedure was successful and he goes for another MRI in January. The only side effect from the sorafenib is elevated blood pressure and he takes medication to control that. He has not experienced the blistering of hands or feet that can be a side effect. All in all, he is tolerating the Nexavar very well. I have an article from the Journal of Oncology from October 2011 titled "TACE and Sorafenib- A Good Marriage?" in pdf format I can share with you if you want to send me your email address. It is technical with medical jargon, but I searched the internet for definitions on any word I was unfamiliar with. I have not noticed where an attachment can be sent here on the discussion board and it is about 3 pages or I would share it.
  • Olgs
    Olgs Member Posts: 10
    #7
    offunspirit said:

    My husband is in a clinical
    My husband is in a clinical trial for sorafenib (Nexavar) at Johns Hopkins in Baltimore, MD. He had the TACE, chemoembolization treatment, in November and is also taking sorafenib (Nexavar)as a combination treatment. From my understanding, the simple explanation is chemoembolization will kill the cancer cells within the tumor and sorafenib is suppose to keep new blood vessels from forming that could become new tumors. The MRI in December shows the TACE procedure was successful and he goes for another MRI in January. The only side effect from the sorafenib is elevated blood pressure and he takes medication to control that. He has not experienced the blistering of hands or feet that can be a side effect. All in all, he is tolerating the Nexavar very well. I have an article from the Journal of Oncology from October 2011 titled "TACE and Sorafenib- A Good Marriage?" in pdf format I can share with you if you want to send me your email address. It is technical with medical jargon, but I searched the internet for definitions on any word I was unfamiliar with. I have not noticed where an attachment can be sent here on the discussion board and it is about 3 pages or I would share it.

    Thank you very much for your
    Thank you very much for your reply! I have found that article myself just minutes ago. I will do some additional research. But I understand your point and actually I've been thinking about the same recently. I mean if a person can take Nexavar without serious side effects and it cound enhance the effect of TACE? Then it really makes sense.
  • chime
    chime Member Posts: 1
    #8
    offunspirit said:

    My husband is in a clinical
    My husband is in a clinical trial for sorafenib (Nexavar) at Johns Hopkins in Baltimore, MD. He had the TACE, chemoembolization treatment, in November and is also taking sorafenib (Nexavar)as a combination treatment. From my understanding, the simple explanation is chemoembolization will kill the cancer cells within the tumor and sorafenib is suppose to keep new blood vessels from forming that could become new tumors. The MRI in December shows the TACE procedure was successful and he goes for another MRI in January. The only side effect from the sorafenib is elevated blood pressure and he takes medication to control that. He has not experienced the blistering of hands or feet that can be a side effect. All in all, he is tolerating the Nexavar very well. I have an article from the Journal of Oncology from October 2011 titled "TACE and Sorafenib- A Good Marriage?" in pdf format I can share with you if you want to send me your email address. It is technical with medical jargon, but I searched the internet for definitions on any word I was unfamiliar with. I have not noticed where an attachment can be sent here on the discussion board and it is about 3 pages or I would share it.

    hi offunspirit, please can u
    hi offunspirit, please can u send the attachment to my email tyangzomla@yahoo.com
    thank you
  • Olgs
    Olgs Member Posts: 10
    #9
    offunspirit said:

    My husband is in a clinical
    My husband is in a clinical trial for sorafenib (Nexavar) at Johns Hopkins in Baltimore, MD. He had the TACE, chemoembolization treatment, in November and is also taking sorafenib (Nexavar)as a combination treatment. From my understanding, the simple explanation is chemoembolization will kill the cancer cells within the tumor and sorafenib is suppose to keep new blood vessels from forming that could become new tumors. The MRI in December shows the TACE procedure was successful and he goes for another MRI in January. The only side effect from the sorafenib is elevated blood pressure and he takes medication to control that. He has not experienced the blistering of hands or feet that can be a side effect. All in all, he is tolerating the Nexavar very well. I have an article from the Journal of Oncology from October 2011 titled "TACE and Sorafenib- A Good Marriage?" in pdf format I can share with you if you want to send me your email address. It is technical with medical jargon, but I searched the internet for definitions on any word I was unfamiliar with. I have not noticed where an attachment can be sent here on the discussion board and it is about 3 pages or I would share it.

    Well, may be I finally need
    Well, may be I finally need to ask you for the file ))) I'm not sure that the one I've got on the web myself is the one I need. Could you be so kind and mail it to me at o.furmanchuk@gmail.com. Thanx!
  • slg
    slg Member Posts: 200
    #10
    Olgs said:

    Well, may be I finally need
    Well, may be I finally need to ask you for the file ))) I'm not sure that the one I've got on the web myself is the one I need. Could you be so kind and mail it to me at o.furmanchuk@gmail.com. Thanx!

    Possible you could just post
    Possible you could just post the link on this site and then everyone can access it easier.
    Thanks.
  • offunspirit
    offunspirit Member Posts: 8
    #11
    chime said:

    hi offunspirit, please can u
    hi offunspirit, please can u send the attachment to my email tyangzomla@yahoo.com
    thank you

    TACE and Sorafenib: A Good Marriage Article
    My apologies for not logging in and responding sooner. Please try the link below for the full article. If link does not work, please search Journal of Clinical Oncology website and then look for archive files. The article was published in the magazine's October 20, 2011 issue.

    http://jco.ascopubs.org/content/29/30/3949.full
  • OlafR
    OlafR Member Posts: 1
    #12
    offunspirit said:

    My husband is in a clinical
    My husband is in a clinical trial for sorafenib (Nexavar) at Johns Hopkins in Baltimore, MD. He had the TACE, chemoembolization treatment, in November and is also taking sorafenib (Nexavar)as a combination treatment. From my understanding, the simple explanation is chemoembolization will kill the cancer cells within the tumor and sorafenib is suppose to keep new blood vessels from forming that could become new tumors. The MRI in December shows the TACE procedure was successful and he goes for another MRI in January. The only side effect from the sorafenib is elevated blood pressure and he takes medication to control that. He has not experienced the blistering of hands or feet that can be a side effect. All in all, he is tolerating the Nexavar very well. I have an article from the Journal of Oncology from October 2011 titled "TACE and Sorafenib- A Good Marriage?" in pdf format I can share with you if you want to send me your email address. It is technical with medical jargon, but I searched the internet for definitions on any word I was unfamiliar with. I have not noticed where an attachment can be sent here on the discussion board and it is about 3 pages or I would share it.

    Article on Sorafenib
    Dear offunspirit,

    Would you be so kind to send me the article published in the Journal of Oncology. In the Netherlands Oncology seems to be very conservative, so I am looking abroad for alternative treatments with positive results. Any futher suggestions are welcome.
    Kind regards and thanks in advance for your time and consideration,

    Olaf
    e-mail: oreinh@gmail.com

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