interim status report on my recurrence treatment on the clinical trial.

I just started a cycle two of my clinical trial that involves Doxil and an experimental immunotherapy drug called VTX2337. Doxil is given once every four weeks. The experimental drug is given three times during the four week cycle.

This protocol has been rough for me. And, this is saying A LOT coming from someone who went through 18 weekly infusion straight without any break without developing any side effects other than blood count tanking and hair lost. I used to exercise 1 - 1.5 hour daily while I was going through the treatment.

The main reason is not Doxil. I don't develop side effects to the chemo drugs. It's the experimental drug. Its side effects are sever flu like symptoms (most immunotherapy drugs seem to have those as side effects). Boy, they were not joking. The day I get the shot, within 5-6 hours I develop severe chills and fever on an alternating cycle. The whole thing is made much worse because when I get the Doxil IV or this drug shot, I have to stay around 4-8 hours so that they can collect blood for research purpose. Remember, I am on a clinical trial, so I have to be a guinea pig. The next two days at the minimum, I am out of commission.

I hope that the fact that I have these reactions mean the drug is working (VTX2337). Earlier in the year, I was on a preventive cancer vaccine trial. They warned of similar side effects. I developed none. I flunked out of this trial (because I recurred). This time I have all the side effects they warned. So, hopefully, it's actually good that I "suffer" like this.

Anyway, a month after the initial treatment, I feel that it's already working. The creepy sensations in the abdominal and pelvic areas are mostly gone - this was also the case with the initial front line therapy earlier this year: withint 2-3 weeks, I felt that the treatment is working since the sensations abated greatly. my cancer cells proliferate very fast (zero to 100 miles in 30 seconds, sort of - meaning, clean tests and what not to recurrence with tumor implant in mere 3 weeks or so, not like most women whose CA125 rise slowly for a few months before anything is seen on the scan. If the treatment had not been working, the four weeks would have intensified these sensations greatly,, not reducing them. So I am guessing it's working.

Furthermore, today at MSKCC just before I got the second Doxil infusion, I asked them to add TSH (thyroid condition) check to my routine blood test. The result came back very encouraging: it's normal again. This is significant to me: Both at the time of initial diagnosis and the onset of recurrence, my hypothyroid condition went completely out of control though all those years the meds were able to keep in under control. When I was in remission, the number went back to normal.

So, the fact that it's back to normal is encouraging. Since CA125 is not a good marker for those on Doxil initially (if anything, it spikes for 50% of the women even when the treatment is working), I can't use that as a way to get a "peek" at treatment efficacy or lack thereof. (mine spiked 300% after the initial Doxil treatment, and though I knew intellectually all about this spike phenomenon, viscerally, I felt like somebody hit me with a brick when I saw that number - this is where the intellect disconnects from the emotion).

Between this and the abdominal/pelvic sensations that have improved vastly, I am hopeful. However, the scan scheduled 3 weeks down the road will give me a conclusive story on how I am doing. If indeed my hunch is right and the treatment is working, I will be beating the stats again with a wide margin, given the % of those labeled "platinum resistant" (which I am) who respond to the second line treatment is less than 20%.

If I am not right, I will have to eat my words, but then again, it will be the least of my problem, won't it?