Anyone has tried GENE therapy and is cured?

I_Promise
I_Promise Member Posts: 218 Member
in Brain Cancer #1
Dear all,

I am looking for people who have considered gene therapy (oncolytic virus). I truly believe that is where the cure lies. I have been reading on HSV, VSV, adenoviruses etc..

Any info would be welcome with open arms. It looks like from 2000-2010 it was all phase I/II clinical trial. A few phase 3.

I spend every night reading about each clinical trials. Comparing notes. Comparing survivals. My sisters life depends on it (AA grade 3).

I am only thinking, breathing, studying everything and anything that is gliomas.

I hate them.

Ok... back to reading articles and finding out where the most promising oncolytic viruses are being studied. If I find anything promising I will post it here.

What I like the most about gene therapy, is the permanence of it. One minute you have brain cancer, the other you don't. One day radiation and chemotherapy are going to be seen as barbaric, the dark ages.

goodnight,

Julia

Comments

  • palmyrafan
    palmyrafan Member Posts: 396
    #2
    Gene Replacement Therapy
    It has been a few months (could even be quite a few months) since I heard the latest news and it was not good. And that was gene replacement therapy did not show as much promise in the treatment of brain tumors as the scientists and researchers had hoped. The test results were inconclusive because they did not show an abundance of people being helped by the therapy as they had hoped would happen.

    Since the time the report came out, I have heard nothing else on the subject.

    Peace,
    Teresa
  • alutiiqmom
    alutiiqmom Member Posts: 256
    #3
    I am very curious about that virus also
    Hi:

    I saw on the internet that they would doing the virus therapy in California. I have not looked for some time, but I am very curious too. Please post whatever you find. The chemo and radiation is so hard on our family members and the brain is so resistant. God's blessing to you and yours.
  • I_Promise
    I_Promise Member Posts: 218 Member
    #4
    alutiiqmom said:

    I am very curious about that virus also
    Hi:

    I saw on the internet that they would doing the virus therapy in California. I have not looked for some time, but I am very curious too. Please post whatever you find. The chemo and radiation is so hard on our family members and the brain is so resistant. God's blessing to you and yours.

    current trials for gene therapy
    Dear all

    This is what I have so far in terms of gene therapy via a virus:


    1) Delta-24-RGD replication-competent adenovirus (MD anderson)
    2) DCA (University of alberta) (not a virus, but interesting)
    3) Modified Polio virus (Duke)
    4) The modified herpes virus HSV1716 (University of Glasgow)
    5) The reovirus REOLYSIN (Cedar-Sinai)
    6) The Dendritic Cell Vaccine (Cedar Sinai, UCLA, Duke)
    7) IMA950 is a therapeutic multi-peptide vaccine at the NIH
    8) The modified Measle virus (Mayo)
    9) IMA950 (A Novel Multi-Peptide Vaccine) Plus GM-CSF (in the UK)
    10) UCLA Linda Nau: have 2 studies where either the patient or a healthy volunteer immune cells are taken and exposed to the tumor. The retrained new and improved immune cells are given back to the patient so that the tumor can be killed.
    11) New Castle Disease Virus (Italy, Germany, Hebrew University)
    12) GP96 Heat Shock Protein-Peptide Complex Vaccine (San Francisco)


    But cautious... none of these trials have convinced me... most are in phase 1 or 2 where the primary objective is "is this new therapy safe?" So the risk to the participant I think is high.

    At the turn of 20th century, people with cancer would sometimes go in remission after they caught the measles (anecdotal evidence). So scientist knew that oncolytic therapy could one day work, but we did not have the technology back then. It is a ver very new science.

    I think the next 10-20 years are going to be interesting.

    Alutiiqmom:

    To answer your question about San Francisco:

    San Francisco
    GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma

    Results:

    Phase 1:

    "In the first group, study results showed tumor-specific immune response was detected after vaccination in all six patients. Researchers observed that patients whose disease was stable after surgical resection and before vaccination were more likely to respond clinically. Of the first six patients treated, five have exceeded the historical median benchmark of 6.5 months survival from time of recurrence. All six have exceeded the overall survival historical benchmark of 14.6 months from time of diagnosis."

    Phase 2:

    The trial involved 33 patients with recurrent glioblastoma treated at UCSF’s Helen Diller Family Comprehensive Cancer Center. 11 patients are still alive and being followed, including 4 beyond one year (374d, 419d, 578d, and 877 days, respectively).


    We are making progress. We are not there yet.

    But a cure will be found.

    Julia
  • alutiiqmom
    alutiiqmom Member Posts: 256
    #5
    I_Promise said:

    current trials for gene therapy
    Dear all

    This is what I have so far in terms of gene therapy via a virus:


    1) Delta-24-RGD replication-competent adenovirus (MD anderson)
    2) DCA (University of alberta) (not a virus, but interesting)
    3) Modified Polio virus (Duke)
    4) The modified herpes virus HSV1716 (University of Glasgow)
    5) The reovirus REOLYSIN (Cedar-Sinai)
    6) The Dendritic Cell Vaccine (Cedar Sinai, UCLA, Duke)
    7) IMA950 is a therapeutic multi-peptide vaccine at the NIH
    8) The modified Measle virus (Mayo)
    9) IMA950 (A Novel Multi-Peptide Vaccine) Plus GM-CSF (in the UK)
    10) UCLA Linda Nau: have 2 studies where either the patient or a healthy volunteer immune cells are taken and exposed to the tumor. The retrained new and improved immune cells are given back to the patient so that the tumor can be killed.
    11) New Castle Disease Virus (Italy, Germany, Hebrew University)
    12) GP96 Heat Shock Protein-Peptide Complex Vaccine (San Francisco)


    But cautious... none of these trials have convinced me... most are in phase 1 or 2 where the primary objective is "is this new therapy safe?" So the risk to the participant I think is high.

    At the turn of 20th century, people with cancer would sometimes go in remission after they caught the measles (anecdotal evidence). So scientist knew that oncolytic therapy could one day work, but we did not have the technology back then. It is a ver very new science.

    I think the next 10-20 years are going to be interesting.

    Alutiiqmom:

    To answer your question about San Francisco:

    San Francisco
    GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma

    Results:

    Phase 1:

    "In the first group, study results showed tumor-specific immune response was detected after vaccination in all six patients. Researchers observed that patients whose disease was stable after surgical resection and before vaccination were more likely to respond clinically. Of the first six patients treated, five have exceeded the historical median benchmark of 6.5 months survival from time of recurrence. All six have exceeded the overall survival historical benchmark of 14.6 months from time of diagnosis."

    Phase 2:

    The trial involved 33 patients with recurrent glioblastoma treated at UCSF’s Helen Diller Family Comprehensive Cancer Center. 11 patients are still alive and being followed, including 4 beyond one year (374d, 419d, 578d, and 877 days, respectively).


    We are making progress. We are not there yet.

    But a cure will be found.

    Julia

    thank you Julia
    Hi Julia:
    Thank you for sharing that information and putting it in layman terms. I find it very hard to look up information when I am so worried about my daughter. Did you research on the Burzynski Clinic in Katy, Texas. Initially, I was all excited but then my friend researched the doctor and he was listed in several articles in Quackwatch. Having said that, a doctor at a clinic in Alaska told me she would take her daughter to him and get any opinion at least. Again, confusing and conflicting reports. I wish you the best. God Bless you and yours. A cure will be found. Yes it will.
    Edna

Discussion Boards