Started CIMETIDIME today. Really happy not following the heard. Naturopathy warning also!

molecularly targeted naturopathy?
The Dingles - wow.

Pete, several caveats. Those odds are for the stage II + III CR cancer mortality only, nothing else. The ultimate determinants of success were perioperative cimetidine with continuous 5FU for a year, and positive CA19-9 and CSLEX biomarkers. Without the biology that produces the biomarkers, there was no advantage, and really, no need for the cimetidine. However, if one is biomarked with both CA19-9 and CSLEX, the nonsignificant 10yr trend was more like 95+% survival if treated with cimetidine+5FU, and relatively fast extinction if not treated with cimetidine - even the biomarked stage II's were all gone in 5-6 years (5Fu only).

Alone, cimetidine is rarely likely to resolve an established tumor (it has happened, that's how cimetidine's anticancer properties were initially found), usually only reducing the spread. Someday I hope my wife gets to the point she can be even more like the LEF protocol by stopping her continuous UFT-LV chemo (she's stage IV, nodes in the lymph system). We don't do some of the LEF protocol, but we do other less toxic treatments, too, to try to checkerboard the molecular targets. She'll always do lots of natural biochemistries, and cimetidine.

pete43lost_at_sea said:

thanks tanstaafl
the caveats are greatly appreciated, I keep on learning each day.
so I am curious, I will check for positive ca19-9 and cslex biomarkers with my onc?

We get on pretty well, I'll email her this thread and see her reaction.

Given I have had a full 12 rounds of folfox, finished 5 months ago.
Maybe I have missed the window where cimetidine will help my stage III.

I would really like to know my biomarker status!

Given the grim prognosis for those in the study that had positive biomarkers, I guess if I
had positive biomarkers then some more 5fu and cimetidine may be very benefical?

hugs,
pete

CA19-9, maintenance chemo
CA19-9 is most informative before surgery, or with active/smoldering disease but still not definitive without the CSLEX, and perhaps some other analyses. A nonzero CA19-9 (result more than 1 or 2), should marginally improve survival benefits by a few percent by removing an extreme non-biomarker subpopulation at surgery, ca 5-10% of stage II-III CRC patients, that simply cannot benefit from cimetidine. CA19-9 should be reasonably priced. On the Asian mainland, one can get a chinese based biomarker battery, called C-12, of 12 biomarkers (no CSLEX) for about $100. I think a CSLEX blood test is almost Japan only, CSLEX tissue staining is mostly rare research groups with the stain.

Pete, I really can't address your situation or any treatment needs. With my wife, a stage IV patient with a large cluster of para-aortic lymph nodes removed, we've decided to try to stop new cancer cell clusters "from landing" to start new mets with a CIM-UFT-LV-PSK-"2/3 LEF"+++ protocol. We do a lot to minimize the long term impact of even (mild) immunochemotherapy. Last year, her biggest named oncologist projected that this month was the expectable median time to expiry even after both FOLFOX-Avastin and FOLFIRI-Erbitux treatments....

However she later breezed through that second surgery over the nay sayers, where no new visible mets were found (surprise!), and have had several surprises for the more conventional medicine, less scientifically, minded. We'll soon see what the CT says. CEA seems to be stabilizing around 2, CA19-9 (~20) is still off its low last year even with the lymph nodes, now with some inflammatory contribution. Although these are "normal range" results, I worry about "smoldering" and would like even lower (better) numbers. We are prepared to attrition maturing micromets, nodules or "lunbg thingies" for several years to see if one can resect to a cure while covering common molecular targets for angiogenesis, and maintaining enhanced immune markers.

Pete can you share the web
Pete can you share the web site for the "chemist" I can't find it. Thanks Stephanie

pete43lost_at_sea said:

thanks tanstaafl
the caveats are greatly appreciated, I keep on learning each day.
so I am curious, I will check for positive ca19-9 and cslex biomarkers with my onc?

We get on pretty well, I'll email her this thread and see her reaction.

Given I have had a full 12 rounds of folfox, finished 5 months ago.
Maybe I have missed the window where cimetidine will help my stage III.

I would really like to know my biomarker status!

Given the grim prognosis for those in the study that had positive biomarkers, I guess if I
had positive biomarkers then some more 5fu and cimetidine may be very benefical?

hugs,
pete

CA19-9 $
Pete, typically used for the superhigh readings associated with pancreatic cancer, CA19-9 should be generally available and cheap enough for self pay. We've paid $30-50.