Anyone used or heard of this.....any opinions ?
What is photodynamic therapy?
Photodynamic therapy (PDT) is a medical treatment that uses a photosensitizing drug (a drug that becomes activated by light exposure) and a light source to activate the applied drug. The result is an activated oxygen molecule that can destroy nearby cells. Precancerous cells and certain types of cancer cells can be treated this way. The procedure is easily performed in a physician's office or outpatient setting.
PDT essentially has three steps. First, a light-sensitizing liquid, cream, or intravenous drug (photosensitizer) is applied or administered. Second, there is an incubation period of minutes to days. Finally, the target tissue is then exposed to a specific wavelength of light that then activates the photosensitizing medication.
Steps:
application of photosensitizer drug
incubation period
light activation
Although first used in the early 1900s, PDT in the modern sense is a fairly new, evolving science. Current PDT involves a variety of incubation times for the light-sensitizing drug and a variety of light sources depending on the target tissue. The basic premise of PDT is selective tissue destruction. Although the photosensitizer may be absorbed all over by many cells, atypical or cancerous cells take up more of the drug and retain the drug for a longer duration than normal tissues.
At present, the primary limitation of available PDT techniques is the depth of penetration of the light and ability to target cells within at most 1/3 of an inch (approximately 1 cm) of the light source. Therefore, tumors or atypical growths must be close to the surface of the skin or treatment surface for PDT to work.
PDT is currently used in a number of medical fields including oncology (cancer), dermatology (skin), and cosmetic surgery.
In oncology, it is FDA approved for non-small cell lung cancer, esophageal cancer, and precancerous changes of Barrett's esophagus. Its use is also being further investigated through clinical trials in general oncology for conditions including cancers of the cervix (mouth of uterus), prostate gland, brain, and peritoneal cavity (the abdominal space that contains the stomach, liver, and internal organs).
Comments
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hi BuzzJohn23 said:Buzz....
There are many options, why take one that's totally experimental?
If this is as popular as they suggest, why is this the first time we're
hearing of it here, on a cancer forum?
Please, allow common sense and basic intuition to prevail?
Stay well,
John
I have not heard of that but i am not seeing a lung doctor(as of yet).but as you know my team of doctors is in louisville.if you think you would want to go that way just letting you know i think there are great docs in that location.sorry i could not be of more help.....Godbless....johnnybegood0 -
More InfoJohn23 said:Buzz....
There are many options, why take one that's totally experimental?
If this is as popular as they suggest, why is this the first time we're
hearing of it here, on a cancer forum?
Please, allow common sense and basic intuition to prevail?
Stay well,
John
Here is a link from the National Cancer Institute:
http://www.cancer.gov/cancertopics/factsheet/Therapy/photodynamic
Perhaps one of the reasons we haven't heard about it, is that it is only used on cancers of the skin, just below the skin or throat where the light can penetrate.
The article indicates that there are clinical trials attempting to expand the use.
Marie who loves kitties0 -
Been Around a WhileJohn23 said:Buzz....
There are many options, why take one that's totally experimental?
If this is as popular as they suggest, why is this the first time we're
hearing of it here, on a cancer forum?
Please, allow common sense and basic intuition to prevail?
Stay well,
John
I just did a search on it John and it goes back over 3000 years ago it seems. It's been used in the past 30-40 years for cancer treatments. It's not new, it might be new to US but it's not new...
"The earliest recorded treatments that exploited a photosensitizer and a light source, in this case sunlight, for medical effect can be found in ancient Egyptian and Indian sources. Annals over 3000 years old report the use of topically applied vegetable and plant substances to produce photoreactions in skin and cause a repigmentation of depigimented skin lesions, as seen with vitilago and leukoderma."0 -
I guess I misquoted this........lemme straighten it out...PhillieG said:Been Around a While
I just did a search on it John and it goes back over 3000 years ago it seems. It's been used in the past 30-40 years for cancer treatments. It's not new, it might be new to US but it's not new...
"The earliest recorded treatments that exploited a photosensitizer and a light source, in this case sunlight, for medical effect can be found in ancient Egyptian and Indian sources. Annals over 3000 years old report the use of topically applied vegetable and plant substances to produce photoreactions in skin and cause a repigmentation of depigimented skin lesions, as seen with vitilago and leukoderma."
I will first see what Vandy has to offer ..I am just trying to have as many options open to me as possible in the event that something is particularly different about this spot or that certain regimens may not do any good...Im not going to make any decision by myself, not just yet. John, thank you for the concern and for being honest to me, I really truly appreciate it, thats what I like about here, there's no holes barred..I have checked into it and yes it has been around a while. There is a Dr in Louisville that has been using it in the esophageal and peritoneal areas with good results...I have an individual here at home that went 3 years ago and is doing very well ...but I will consider all avenues and return with questions and verdicts as soon as I make the trip Wednesday.....I meet her at 3 pm..I should be back on by 6 or 7 pm with outcome.....thank you all..buzz0 -
In relation to lymph nodes,"Photodynamic theraphyBuzzard said:I guess I misquoted this........lemme straighten it out...
I will first see what Vandy has to offer ..I am just trying to have as many options open to me as possible in the event that something is particularly different about this spot or that certain regimens may not do any good...Im not going to make any decision by myself, not just yet. John, thank you for the concern and for being honest to me, I really truly appreciate it, thats what I like about here, there's no holes barred..I have checked into it and yes it has been around a while. There is a Dr in Louisville that has been using it in the esophageal and peritoneal areas with good results...I have an individual here at home that went 3 years ago and is doing very well ...but I will consider all avenues and return with questions and verdicts as soon as I make the trip Wednesday.....I meet her at 3 pm..I should be back on by 6 or 7 pm with outcome.....thank you all..buzz
against cancer" at: physorg.com/news/2011-02-photodynamic-therapy-cancer.html
for article of 2/9/110 -
i have had photodynamic
i have had photodynamic therapy for bcc (skin cancer) and it was excellent!
worked beautiful and was non traumatic.
obviously may be different for cancer of the throat, but in my reading 5 years ago, before i had it, i have read of its uses for throat cancer, and its benefits...
if your onc suggests it, its worth while looking into its success rates, as the photosensitising cream used is completely safe to ingest, and the red light used is safe, so is a good ,safe procedure if it is suited to what you need it for...0 -
Why not colorectal?
Sounds interesting. One would think rectal cancer would be an easy target for this. Heck, I probably could have see my tumor with a mirror and a flashlight...0 -
My thoughts on it.........tootsie1 said:New to me
Hey, Buzz.
I hadn't heard of it, but it sure sounds like something to investigate. Let us know what you find out! Hope you're doing well.
*hugs*
Gail
Even if the PDT is for mostly superficial cancers it may be helpful to me if my cancer is early stage and hasn't gotten a large foothold in the throat.My issues are that I don't want to spend 6-8 weeks recouping to find that its somewhere else, and then again and again....I am waiting to see what the Onc has in store for me...I know that my liver may have some issues and I will deal with that as I need to also, But in the grand scheme, I also don't want to see my family go through the same day after day, week after week. Even when I speak that I have no issues at all with any of it, then they walk up behind me and see the tear, they know...Im still in that "limbo" stage that goes with the unknowing where I am at in this fight. Thats where I am right now, not sure whether I am coming or going, I will know more tomorrow evening and will be back with my buddies swapping stories and getting a game plan together............love to ya all....buzz0
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