permanent liver damage from chemo, irinotecan may lead to increased mortality after liver surgery UP

pete43lost_at_sea said:

how to minimise folfox liver damage with adomet
how to minimise folfox liver damage with adomet

game set and match to good quality research and patience

another food supplement that our doctors have not advised about.
http://en.wikipedia.org/wiki/S-Adenosyl_methionine

this post has been flagged, if it gets deleted so does one medically approved treatment to minimise liver damage while on folfox. see the trial data.

its too late for my liver my folfox is finished.

consider the livers saved by this thread, adomet means less drop off folfox and goto more dangerous chemos. just think about it.

cheers all

pete

The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retrospective analysis in patients affected by resected colorectal cancer treated with adjuvant FOLFOX regimen.
Vincenzi B, Santini D, Frezza AM, Berti P, Vespasiani U, Picardi A, Tonini G.
SourceUniversity Campus Bio-Medico, Medical Oncology , Via Alvaro del Portillo 200, 00128 Rome , Italy +39 06 225411123 ; +39 06 225411208 ; b.vincenzi@unicampus.it.

Abstract
Background: Hepatic toxicity is often related to chemotherapy agent administration, and it represents one of the principal causes of dose reduction and chemotherapy delays or discontinuation. S-Adenosyl methionine (AdoMet) supplementation is effective in the treatment of a variety of liver injuries, but it has never been evaluated in the prevention of chemotherapy-induced liver damage. Patients and methods: A total of 105 patients affected by resected colorectal cancer (CRC) were enrolled. Forty-five were treated with FOLFOX IV adjuvant regimen without administering AdoMet, 60 were treated with the same regimen plus supplementation with AdoMet. Liver enzyme levels were assessed before starting the treatment and every therapy cycle. Liver toxicity, chemotherapy course delays, discontinuations and dose reductions due to liver toxicity were recorded. Results: Aspartate aminotransferase (AST) (p < 0.001), alanine transaminase (ALT) (p = 0.003), bilirubin (p = 0.04) and gamma-glutamyltransferase (γ-GT) (p = 0.002) median level at the end of adjuvant therapy were significantly lower in patients treated with Adome. Patients supplemented with AdoMet experimented a lower grade of liver toxicity (p = 0.002) and had a reduced need of course delay (p < 0.0001) and dose reduction (p = 0.031). Conclusions: The results of our study demonstrate a protective effect of AdoMet supplementation in patients affected by resected CRC treated with FOLFOX IV adjuvant regimen.

PMID:21406026[PubMed - in process]

pete43lost_at_sea said:

thanks kenny
hi kenny,

i am starting adomet tomorrow, will let you know the results.

would you mind posting or pming your liver numbers and i'll send you mine.

cheers,
pete

pete43lost_at_sea said:

thanks raquel
hi raquel,

i have to work on my expression, sometimes i am to blunt, or the meaning gets lost.
but the studies are cut and pasted and really speak for themselves.

hugs,
pete

ron50 said:

It is a matter of perspective
Back in 98 I asked my oncologist what the long term side effects of my chemo would be . His exact words were Ï don't know and I really can't worry about it. If we find something that kills cancer and is survivable to the patient we are obliged to use it". We had a good discussion and in the end I agreed that yes desperate situations require desperate meaures. I have suffered some pretty bad long term effects of chemo ,or so they think. BUT I have equally bad side effects from arthritis drugs ,so I guess I have a 50/50 average. BUT I am still alive and the past 13 + year has not been all bad I have Lived ,Loved,worked and played. My philosophy is to consder things before I do them but once I have reached a descision there is no regrets and I don't worry about what ifs. Worry will kill you long before what you are worried about.
Don't get downhearted Pete and don't give up,once you get used to them ,feet taste pretty good. Just remember that some of the worlds greatest thinkers and inovators thought outside the box.
Gail don't forget that I was an aggressive st3c with 6/13 nodes affected ,you can beat it and hang around to a granny and if you don't mind me saying you look perfectly fine to my old eyes.
I am and always will be an accidental tourist of ca . I don't know anything special that helps me survive I just do it and try to support all those who are fighting it. We are all in the same boat please be kind to eack other,Hugs to all .Ron.