anyone heard of PTEN?

grannyc
grannyc Member Posts: 63
in Colorectal Cancer #1
My TCM guy put me on brocoli seeds to help turn on my PTEN...I guess my PTEN went on vacation and is not attacking my cancer cells. I have learned some interesting things from him and the supplements he has me on seem to be helping with my side effect from the Xeloda.

I posted a couple of days ago about being so emotional since recurrance so I asked him about it and he said he thought my hormone levels are messed up and the chemo isn't helping that so we are trying something for low Tyroid to see if that will help.

I hope I continue to feel good as I am going on vacation in about a week and a half to DC and I live in Washington state so the trip itself will be a long day.

Grannyc

Comments

  • Buckwirth
    Buckwirth Member Posts: 1,258 Member
    #2
    PTEN is a protein that regulates cell growth
    http://www.breastcancer.org/risk/new_research/20071211a.jsp

    http://en.wikipedia.org/wiki/PTEN_(gene)
    In molecular biology, phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene.[2] Mutations of this gene are a step in the development of many cancers.

    Not sure how broccoli seeds can un-mutate a gene...
  • sharpy102
    sharpy102 Member Posts: 368 Member
    #3
    PTEN
    PTEN inhibits the conversion of phoshatydil-inositol diphosphate (PIP2) into phosphatydil-inositol triphosphate (PIP3) which if formed, it would then activate both K-Ras and Akt both that are helping in cell survival, cell proliferation and cell growth. I think there's so far no treatment that can somehow overexpress PTEN, or activate, or restore the mutation in the existing PTEN that's why most treatments try to target either K-Ras itself, or components downstream that K-Ras would activate. I think Akt is also being targeted for chemo treatments...I hope this made sense to you. Thought I'd share with you what I've learned last semester...
    Good luck! I hope at least this information above cheers you up! :)
  • Buzzard
    Buzzard Member Posts: 3,043 Member
    #4
    sharpy102 said:

    PTEN
    PTEN inhibits the conversion of phoshatydil-inositol diphosphate (PIP2) into phosphatydil-inositol triphosphate (PIP3) which if formed, it would then activate both K-Ras and Akt both that are helping in cell survival, cell proliferation and cell growth. I think there's so far no treatment that can somehow overexpress PTEN, or activate, or restore the mutation in the existing PTEN that's why most treatments try to target either K-Ras itself, or components downstream that K-Ras would activate. I think Akt is also being targeted for chemo treatments...I hope this made sense to you. Thought I'd share with you what I've learned last semester...
    Good luck! I hope at least this information above cheers you up! :)

    Don't know about cheering up but sure as heck amazes me....
    at your knowledge level...Keep up the great work there young lady...I expect nothing but great things out of you...love ya Sophie....take care......

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