Looking for advice

Hello all. I have only posted once or twice here but I read the posts almost every day. My 54 year old husband, Rickie, was diagnosed with stage IV EC October 8th. He is being treated at MD Anderson in Houston. When he was first diagnosed we were told the tumor was quite large encompassing his whole esophagus. From the reports is says that it "starts at 20 cms and involves the entire length of the esophagus from 20 cms to 40 cms and extends distally into the stomach for about 4 cms to 44cms". There is metastatic involvement of multiple lymph nodes as well as a few "hot spots" on his spine and sternum. Not being a candidate for surgery, the doctors decided to treat with palliative chemotherapy. No other organs are involved that we know of at this time. From what I have read and researched it seems that a tumor this large in unusual. I was wondering if anyone else has experienced this. Although he has lost 90 lbs, he presently weighs around 185 lbs and Dr. Ajani does not think a feeding tube is necessary. He received the first round of chemo, which he tolerated well except for constipation. The chemo gave somewhat mixed results, and so we elected to join a clinical trial for IMC-1121B ramucirumab. In 2 weeks we will have finished 6 weeks on the trial and will have a CT scan to see how he is progressing. If it is getting worse we will discontinue it and try something else. We know that this is not curable, but we hope and pray for time.
The last few days have been difficult as he was having a lot of pain in his back. They upped his pain medication which seemed to help. Yesterday we had a scare as his blood pressure (which is usually somewhat high) dropped. We visited our oncologist in our hometown and he administered IV fluids yesterday and again today as well as iron. Rickie has always been one to drink lots of water during the day and has continued to do so. He also drinks gatorade. We know that all the meds cause constipation and he is suffering through a severe case of it now. Does anyone have any experience with this either? He takes Miralax daily but nothing seems to be helping at this time. Since the chemo he has been able to eat fairly well, however he has developed alot of clear mucous lately that usually comes up with the first few bites of his meal. Our doctor at MD Anderson has not really given us any indication on the progression of the disease. I know in so many of the stories I have read the liver has been involved and at this time my husband has not had that. I guess I am just concerned that it is getting worse and feel that no one there wants to put that out in the open. We are trying to stay positive but it is difficult. It's amazing how your world can be turned upside down so quickly. As I said we pray for time; time for us as a family, time for new developments in medications, and time to understand.