Osteoradionecrosis treatment with pentoxyphiline, clodronate, prednisolone and Vitamin E treatmene,

Mavish

Hi all,

I wonder if anyone tried above meds for in combination for Orn treatment? If so what was their condition before and after the treatment. I have ORN since 2018, following head and neck RT for tonsils cancer.

Chris

wbcgaruss

I have not tried the combination you list, and the one I am familiar with does not use Prednisolone.

I was going to use it before my last extraction, but you need to swallow the one pill whole because it is a time-release pill, and I have an issue with pills risking getting stuck, so I could not use them.

If you have had ORN since 2018, are you working with a doctor to try to resolve it?

If it has been that many years, how has it affected your jawbone where the ORN is?

Have you tried HBOT (Hyperbaric Oxygen Treatment)

I would say work with your doctor and try it, the combination is supposed to promote healing, so you have nothing to lose and healing to gain.

I will post some links below, maybe they will be helpful to you.

I hope you are working closely with a doctor on this; if not, I surely recommend you get with a doctor or medical team and address this.

It is probably best addressed at a major hospital, a teaching hospital, or an oral surgeon with experience at this.

Take Care, God Bless

NEGU (Never Ever Give Up)

Russ

The use of pentoxifylline, tocopherol and clodronate in the management of osteoradionecrosis of the jaws

https://www.thegreenjournal.com/article/S0167-8140(20)31253-6/abstract

Pentoxifylline – a review of its use in osteoradionecrosis

https://www.sciencedirect.com/science/article/abs/pii/S026643561630715X

New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol

https://link.springer.com/article/10.1186/2055-7124-18-13

Osteoradionecrosis after head and neck radiation

https://www.youtube.com/watch?v=VZBnUwMm68A

How does hyperbaric oxygen therapy work?

https://www.youtube.com/watch?v=6XFx35whGns

Healing Wounds with Hyperbaric Oxygen Therapy (HBOT)

https://www.youtube.com/watch?v=MR04LPyQT2k

Mavish

Hi Russ,

Thanks so much. I have a doctor, who prescribed them. Just want to learn others experiences. I was told they are effective in only 25% of the patients.

God bless

wbcgaruss

Very good Mavish I hope and pray that you get a full effect and the ORN is completely eliminated.

Wishing you the very best…

Take Care, God Bless

Russ