Acute cholinergic syndrome on Irinotecan

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Has anyone experienced this? I had a pretty intense adverse event involving flushing, sweating, disorientation/dizziness, low heartrate and hypotension during my first infusion that was controlled in the clinic with Atropine but recurred periodically for the next 12 hours at home. Going in tomorrow for my next infusion and not feeling confident about the plan to do a better job to control it this time. It was pretty scary. Has anyone else had this reaction and have advice on how to manage it at home?