Post Tagrisso***

Hope66G

Anyone try Tagrisso and then found out it stopped working? What did you do then? Thanks.

eDivebuddy

Sorry you're going through this . it must be incredibly frustrating. I don't have an EGFR mutation but here's what I can pass along.

When Tagrisso stops working, the next steps depend heavily on what new mutations may have emerged or what’s believed to be driving resistance. Fortunately, there are some promising new options to consider.

• Targeted combinations like lazertinib + amivantamab. This combo has shown encouraging results, especially in cases where MET amplification or other EGFR-related resistance pathways are involved. It’s already approved in some settings after Tagrisso resistance. It was approved in 2024.

• Next-generation antibody-drug conjugate Drugs like datopotamab deruxtecan are designed to deliver chemotherapy directly to cancer cells using a TROP2-targeting antibody, limiting collateral damage to healthy tissue.It was just approved for EGFR mutated lung cancer as a 2nd line treatment.

Both are cutting-edge options. the NCCN recommends a liquid biopsy on progression with EGFR mutated lung cancers.. that is your best first step in choosing the right path

Hope66G

https://csn.cancer.org/discussion/comment/1723451#Comment_1723451

Thank you for your reply! I am the spouse (husband) (aka, caregiver). Things were stable but recent report, discouraging. I feel so empty inside, and feel like sobbing all the time. The pain I feel inside is great. It is nice to hear some encouraging options you mentioned. Thanks..

Hope66G

Are there any sites you'd recommend that can help me learn about any options/therapies out there? I did recently read about a promising drug that received approval in China. Did you hear about that one? "Orpathys" I think was the name of it.

eDivebuddy

Yes it's a MET 14 targeted drug currently in clinical trials. MET 14 can be an acquired resistance pathway in EGFR Cancers so it very well be an option. The first step is the liquid biopsy to find her best potions.

One of my favorite sites is Vanderbilts My Cancer Genome . It's all about cancer genetic drivers and their treatments and clinical trials.

https://www.mycancergenome.org/

While it's not doubt scary, cancer treatments are advancing rapidly.

Hope66G

https://csn.cancer.org/discussion/comment/1723455#Comment_1723455

Thank you. What is really upsetting is, the patient never smoked. I've read this is becoming more common, which, boggles my mind.

eDivebuddy

Yeah it's pretty stunning how hard it is to change the narrative