Immunotherapy for Non-Small Cell Lung Cancer using DNA Sequencing?

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surf2kona
surf2kona CSN Member Posts: 1 Member
in Lung Cancer #1

My mother-in-law who is 84 years old was diagnosese with Stage 4a non-small cell lung cancer. Its in the right lung and in some lymph nodes they tested. Nothing in the bones or brain scans. we are still waiting on DNA sequencing.

Does anyone know of a good sources for papers or information about immunotherapy treatments that work for specific DNA types?

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  • eDivebuddy
    eDivebuddy CSN Member Posts: 145 Member
    #2

    Sorry your family is going through this. Right now, there aren't any immunotherapy treatments that are reliably tailored to specific DNA mutations in NSCLC. Most targeted therapies are designed for driver mutations like EGFR or ALK, which actually tend to steer people away from immunotherapy. PD-L1 expression and tumor mutational burden (TMB) are still the main biomarkers guiding immunotherapy decisions. Once the sequencing results are in, we can better interpret what they might mean for treatment options but there’s no one-size-fits-all immunotherapy by mutation type yet. KRAS G12C does show some added responsiveness to immunotherapy, but most mutations still respond better to targeted therapy or chemotherapy when applicable.

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