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Kras and Her2

3butterfly
3butterfly CSN Member Posts: 5 Member
in Lung Cancer #1

Hi

More biopsy results are coming in for my mom and I am still waiting for the Dr to call. Does anyone else have Her2 positive and Kras positive adenocarcinoma?

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  • eDivebuddy
    eDivebuddy CSN Member Posts: 155 Member
    #2

    I do not have HER2 or a KRAS mutation. Also I'm not a doctor, and her oncologist will be the authority.

    HER2 (also known as ErbB2) and KRAS 12C both have targeted therapies available. How they are used will be up to her treating oncologist and tumor board. The dominant driver of her cancer is likely to be key in her treatment decisions.

    If her tumor shows HER2 amplification or 3+ protein expression, it strongly suggests HER2 may be the dominant driver, making HER2-targeted therapies like Enhertu or trastuzumab more effective.

    However, if LESP1 or STK11 are present, KRAS is more likely to be the driver. In this case, sotorasib (Lumakras) and adagrasib (Krazati) are approved for KRAS 12C mutations. Immune checkpoint inhibitors are also used for KRAS-mutated cancers, especially with high PD-L1 expression or tumor mutation burdens.

    Ultimately, a multidisciplinary team of specialists, called a tumor board, will review her unique case. The oncologist will review all test results, including NGS and other biomarkers, to determine the most effective treatment plan. While the presence of HER2 and KRAS mutations makes her cancer somewhat more complex, it’s not insurmountable.

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  • 3butterfly
    3butterfly CSN Member Posts: 5 Member
    #3

    This is all alot to learn. Thank you so much for your information. Maybe that is the hold up of calling us they are reviewing the options? Hopefully they call tomorrow or very soon. Trying to understand all the results coming in is very overwhelming. And as she is also in heart failure and has a brain aneurysm this is a huge complication for them all to figure out what is best.

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  • eDivebuddy
    eDivebuddy CSN Member Posts: 155 Member
    #4

    There's always so much information,new swords and acronyms sometimes I feel like you need a translator to understand anything.

    Tumor boards generally meet on a regular schedule. Depending on the institution they can vary widely in frequency. Genetic testing, while vastly improved, can still take a while as well.

    Hopefully it's soon.

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