Irinotecan and UGT 1A1 Genotyping

DanNH Member Posts: 184 Member
edited October 2022 in Colorectal Cancer #1

My Pam has had a harsh reaction to Folfiri since her first infusion with it. She has had 15 infusions with it so far.

So a month ago a CNP ordered a blood test, UGT1AA Genotyping. A week or so later we got the results: variant(s) detected.

We learned that what this means is that Pam cannot process Irinotecan (and some other drugs) normally; it takes her body longer than normal to process it. That explained the harsher reaction and they adjusted the dose down.

Apparently it is genetic (Gilbert Syndrome) and is passed along to some family members. Raised Bilirubin levels could be a symptom.

We never heard about this anywhere before and wanted to make everyone aware of it.