Clinical Trial KRAS G12C - Adagrasib (MRTX849) + TNO155 = Acne

Jennifer7000

Hello everyone,

I have searched some terms and found no on point results, hence my new topic creation here.

I have metastisised colon cancer with KRAS G12C mutation and have just started a drug trial with the new targeting drug, Adagrasib (Merati's MRTX849) combined with SHP2 inhibitor TNO155.

I have 2 main side effects from I believe the TNO155: water retention, and acne. For the first one I'm researching natural diuretics.

For the acne - I'm desperately trying to connect with people who have acne from targeted therapies (not chemo - I think this is different?) to discuss solutions. I'm also really looking for any non-chemical solutions as well due to possible interactions with these trial drugs.

Anyone with experience with acne from targeted therapies?
Anyone with experience with those specific trial drugs?

Fingers crossed!

P.S. This KRAS mutation is more common in lung cancer than colon - and so there will be more lung cancer patients on this trial, that's why I posted in 2 discussion boards. Hope thats ok.