Questions about DOXIL

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So my fiance is battling stage 4 breast cancer that mataticized in her bones. Shes been through all kinds of treatments before hand but now that it spread to other places in her bones they decided to put her on doxil. She has recieved 2 treatments this far. And the second one kicked her butt! And I mean it's been a horriable month. Loss of appetite and loss of fatigue and i mean shes been stuck in bed or the couch and only leaving the house for doctor appointments only. So it's been a tough journey right now. And her tumor markers jumped up so I'm nervous. Is this normal? And how long did it take anyone of you to start seeing positive results from this treatment!? We would truly love any feed back! Thank you very much and merry christmas and god bless you all!