HU5F9-GR with Avelumab clinical trial

longdistance_caregiver
longdistance_caregiver Member Posts: 5
in Ovarian Cancer #1

Hello,

I'm a new member and only just found this forum. My mom has been battling a second round of Ovarian since 2016 (was previously 10 years in remission). After running through all the platin-based chemos, her cancer is now considered platinum resistant. Doctor is out of options other than putting her on Tamoxifen, but CA-125 numbers are going up (on it for about a month). I'm also having my mom take curcumin. (on it for a couple of weeks).

We are looking into the clinical trial above and I wanted to know if anyone else has had any experience good or bad with either drug or the combined trial. I know the Avelumab phase III trial for Ovarian cancer was ended (failed to obtain progression free survival) but it is being looked at again in combo with this new drug.


 

We're trying to decide if we should give the Tamoxifen longer to work or pursue the trial. Not able to do both.

 

Many thanks!

Comments

  • Tethys41
    Tethys41 Member Posts: 1,382 Member
    #2
    Tamoxifen

    Hi longdistance,

    I am a little confused by your question.  Does your mom have a stromatal tumor?  They generally don't use Tamoxifen for the more common form of ovarian cancer, epithellial.

    Or are you saying she is on Topotecan?  

    Maybe a second opinion would give you more information to work with.

     

  • longdistance_caregiver
    longdistance_caregiver Member Posts: 5
    #3
    Tethys41 said:

    Tamoxifen

    Hi longdistance,

    I am a little confused by your question.  Does your mom have a stromatal tumor?  They generally don't use Tamoxifen for the more common form of ovarian cancer, epithellial.

    Or are you saying she is on Topotecan?  

    Maybe a second opinion would give you more information to work with.

     

    Tamoxifen

    Hi Tethys

    She was on Topetecan awhile back but now it is Tamoxifen. I honestly don't know what kind of ovarian cancer she has and am not familiar with either of those terms. I'm trying to help her from afar so don't have all of the info.

    The question was more relating to the clinical trial on HU5F-G4 and Avelumab together and whether anyone else was familiar with it or is taking part in it

    Thank you

  • longdistance_caregiver
    longdistance_caregiver Member Posts: 5
    #4
    longdistance_caregiver said:

    Tamoxifen

    Hi Tethys

    She was on Topetecan awhile back but now it is Tamoxifen. I honestly don't know what kind of ovarian cancer she has and am not familiar with either of those terms. I'm trying to help her from afar so don't have all of the info.

    The question was more relating to the clinical trial on HU5F-G4 and Avelumab together and whether anyone else was familiar with it or is taking part in it

    Thank you

    Clinical trial

    I should add that the first doctor stopped chemo with my mom as it wasn't working except the taxotare which was just destroying her and that the clinical trial is what came out of the 2nd opinion. At any rate, looks like we're proceeding with the screening process on the clinical trial. If we get accepted, I'd be happy to share our experiences with the forum.

    Best

  • Tethys41
    Tethys41 Member Posts: 1,382 Member
    #5
    Good luck

    I would probably opt for the trial, if I was in her shoes.  I hope all goes well.

Discussion Boards