St. John's Wort

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St. John's Wort is not usually known for an anti-cancer effect, but this abstract indicates it may be useful: https://www.ncbi.nlm.nih.gov/pubmed/30063472

Cancer cells disseminate to other parts of the body during metastasis through the process of intravasation. The hypericin and hyperforin [St. John's Wort] effect has been described to understand the signal mechanisms that stimulate or stunt cancer cell sprouting to metastasis on colon adenocarcinoma cells HT-29 and its resistant form HT-29-OxR. We focused on the key points of adhesion proteins (cadherin, integrin, selectin and syndecan) and also proteins participating in or contributing to the process of cancer cell migration and adhesion through genes expression and proteins levels. Treatment effects were identified as a consequence of decreased cell adhesion, changes of expression in the adhesive proteins as well as basal membrane degradation associated with changes in the expression of matrix proteinases and in their activity. Finally, the cells affected by hypericin or hyperforin were evaluated by monitoring the cancer cell adhesion properties and proliferation processes.

This summary article covers a lot of supplements, but mentions a correlation between taking St. John's Wort and a 65% reduction in the initial incidence of colon cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814533/

There were also statistically significantly inverse associations of fish oil: HR: 0.65 (95% CI: 0.42, 0.99), methylsulfonylmethane (MSM): HR: 0.46 (95% CI: 0.23, 0.93), and St. John's wort: HR: 0.35 (95% CI: 0.14, 0.85) with CRC risk.