saliva glands can they be transplanted
I had radiation to the head and neck and it fried 1 part of my saliva gland. All I have is the sticky part and it makes eveything hang in my throat. Although I have a feeding tube I cough alot because of that saliva. I found a doctor that can help me swallow food again by reconstructing my throat and removing my voice box but if I don't have both parts of the saliva it might be really hard. Does anyone have any experience in this? BNSmith
Comments
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More Info
Hello-could you please post what kind of cancer you had and the treatments you went through
including surgeries, radiation, chemotherapy etc. to help understand your status.
How long has it been since you finished treatment?
It takes awhile sometimes till the saliva comes back and the gagging stops.
And also if you had radiation on your throat area it takes awhile for healing and the swelling to go
down so you can swallow again maybe you need to just be patient and give it more time.
Many on here have been through some difficult treatments and have very limited saliva and I
have had 4 throat dilations where they slowly expand the throat again which you may consider
and it helps you to swallow again.
I have read these forums for quite awhile and have never heard of having a voice box removed so you
could swallow again so more information on your treatment and situation would be very helpful to the
group to help give you information that might help you.
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I struggled with thick saliva
I struggled with thick saliva for a while. I learned that the same products that help with no saliva will work with thick. Now I use xylamelts during times when I'm heavily distracted, and for the rest lozenges like Pur and Therabreath. There are buckets of products, sprays, washes, etc. I wouldn't give up hope, just try one, keep if it works, move on if it doesn't.
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more infowbcgaruss said:More Info
Hello-could you please post what kind of cancer you had and the treatments you went through
including surgeries, radiation, chemotherapy etc. to help understand your status.
How long has it been since you finished treatment?
It takes awhile sometimes till the saliva comes back and the gagging stops.
And also if you had radiation on your throat area it takes awhile for healing and the swelling to go
down so you can swallow again maybe you need to just be patient and give it more time.
Many on here have been through some difficult treatments and have very limited saliva and I
have had 4 throat dilations where they slowly expand the throat again which you may consider
and it helps you to swallow again.
I have read these forums for quite awhile and have never heard of having a voice box removed so you
could swallow again so more information on your treatment and situation would be very helpful to the
group to help give you information that might help you.
Thanks for responding to my thread. I had a sarcoma at the base of the skull where all the nerves go to the brain!! It was in 2005 and I had 35 radiation treatments. I was eating ok for a couple of years then as years kept coming my eating kept getting worse and I have been on a feeding tube for 3 years now. I can't even swallow water. Emory Univ in Atlanta did the surgery and Rome, Ga did my radiation treatments. But oh if I had it to do over I would definitely gotten a second opinion. Anyway at Mt Sinai Hosp in New York there is a doctor named Dr Mark Urken that reconstructs the throat and inserts a prosthesis that diverts the food into the esophagus. My problem is that everything goes into my lungs and I end up in the hospital with pneumonia. I have been in the hospital 3 times in the last 5months. The surgery is sort of a laryngotracheal procedure. I was hoping that if I do get to eat again it would be helpful to have saliva to help send it down because on top of everything else the right side of my tongue is paralyzed so that makes it even harder to move food in the mouth. But I am still glad to be alive and PRAISING the LORD for letting me live. Thanks again for your input.
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thick salivaAnotherSurvivor said:I struggled with thick saliva
I struggled with thick saliva for a while. I learned that the same products that help with no saliva will work with thick. Now I use xylamelts during times when I'm heavily distracted, and for the rest lozenges like Pur and Therabreath. There are buckets of products, sprays, washes, etc. I wouldn't give up hope, just try one, keep if it works, move on if it doesn't.
Thanks for your input. I will try some of those, I have seen them in the store but just went right on by. So far everything I have tried doesn't work. Thanks again for the info.
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SALIVA MIRACLE
Hey BJN,
The entrance to my esophagus was fibrosed closed, and my saliva glands were fried into extinction by treatment in the Rad Dungeon, so I was a PEG feeder, and had the joy of periodically excavating from my mouth, large quantities of industrial grade viscosity mucus, no saliva, for 11 years. In 2011 I had my esophagus reconstructed (with after market parts), along with a laryngectomy after which I was at long last, and more than joyfully able to swallow again; liquids only, but I love it. A few months after the dance in the surgical suite, I was noticing that the viscosity of my mucus was becoming not so much industrial grade and more fluidy, alright cool enough, that's all good. Then, one day, while getting a routine follow-up evaluation, my ENT informed me that the fluid in my mouth was not mucus, but was.............wait for it ..................in fact saliva! I was way more than amazed; my saliva glands were unextincted, and once again pumping out that wonderful, and I believe all to often under appreciated, fluid- saliva! Now, I am thankfully here to tell you that, for me, that re-awakening of my salivary glands was truly, undoubtedly, unmistakably an amazing miracle!! I have not heard of anyone else who has had a similar experience, so I consider myself most extremely fortunate to have experienced this wonderful change in my salivary glands functioning. Once your esophagus is reconstructed, saliva may not be the most significant factor for swallowing, but you will probably have to wait until the healing is in to find out what factors will be important for your swallowing. So, hang in there, as you deal with the many wait and sees that you are dealing with as you go through the esophagus reconstruction and laryngectomy odyssey. I send my very best wishes for you on your re-swallowing adventure.
Patrick
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saliva miraclepatricke said:SALIVA MIRACLE
Hey BJN,
The entrance to my esophagus was fibrosed closed, and my saliva glands were fried into extinction by treatment in the Rad Dungeon, so I was a PEG feeder, and had the joy of periodically excavating from my mouth, large quantities of industrial grade viscosity mucus, no saliva, for 11 years. In 2011 I had my esophagus reconstructed (with after market parts), along with a laryngectomy after which I was at long last, and more than joyfully able to swallow again; liquids only, but I love it. A few months after the dance in the surgical suite, I was noticing that the viscosity of my mucus was becoming not so much industrial grade and more fluidy, alright cool enough, that's all good. Then, one day, while getting a routine follow-up evaluation, my ENT informed me that the fluid in my mouth was not mucus, but was.............wait for it ..................in fact saliva! I was way more than amazed; my saliva glands were unextincted, and once again pumping out that wonderful, and I believe all to often under appreciated, fluid- saliva! Now, I am thankfully here to tell you that, for me, that re-awakening of my salivary glands was truly, undoubtedly, unmistakably an amazing miracle!! I have not heard of anyone else who has had a similar experience, so I consider myself most extremely fortunate to have experienced this wonderful change in my salivary glands functioning. Once your esophagus is reconstructed, saliva may not be the most significant factor for swallowing, but you will probably have to wait until the healing is in to find out what factors will be important for your swallowing. So, hang in there, as you deal with the many wait and sees that you are dealing with as you go through the esophagus reconstruction and laryngectomy odyssey. I send my very best wishes for you on your re-swallowing adventure.
Patrick
Hey Patrick, I don't know if you realized that the thread was from me. I have been meaning to ask you about the saliva glands and I keep forgetting. That is good to know about how yours came back. Also are you strictly on liquids now or can you eat soft foods like potatoes, pasta and eggs? I sure hope my glands come back to life it would make eating and my stomach feel alot better. Thanks for the input. Brenda
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SMOOTHIE OPERATORBJNsmith53 said:saliva miracle
Hey Patrick, I don't know if you realized that the thread was from me. I have been meaning to ask you about the saliva glands and I keep forgetting. That is good to know about how yours came back. Also are you strictly on liquids now or can you eat soft foods like potatoes, pasta and eggs? I sure hope my glands come back to life it would make eating and my stomach feel alot better. Thanks for the input. Brenda
Hey Brenda,
I did recognize that you had posted your question. I am on an all smoothie diet all of the time because I am missing a majority of my tongue due to the BOT surgery, and then, after my laryngectomy I lost a bit more of it; and after my last surgery in 1/17 to remove some tumors from the soft palate in my mouth, I lost another bit more of my tongue, along with the two molars, on the right side, that prior to the last surgery, allowed me to eat some easily disintergrated foods like chips. I just returned from the International Association of Laryngectomees Annual Meeting and Voice Institute, which was held in Orlando last week, and I as usual, brought my trusty NutriBullet Rx with me and enjoyed blended meals in the hotel restaurant, Applebee's, as well as some blended meals in my room. The Meeting and Voice Institute were tremendous for the social and educational experiences which I and the other attendees enjoyed.
Patrick
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I had esophageal atresia at birth, and had my top windpipe part disconnected from my lung and then re-connected down below where it should have been...a day or two after my birth. It was in 1950, so the procedure was unusual and I have an ugly scar running the length of one of my posterior scapula....it tends to get adhesions and pulls my thoracic spine into a bit of a curve. As I have aged, my allergies have gotten worsed......I usually get a bad cold after a bad allergy attack, and by the time the cold runs its' course, I have hacked up a lot of thick mucous & post nasal drip. Even when I don't have a cold, I tend to expectorate a goodly amount of mucous w/ post nasal drip. Well, I have a friend that had throat cancer so he now has no active saliva glands after they were radiated. Is it possible that my post nasal drip can be mitigated by removing a saliva gland ? My PND is so irritating and quite often active. I am always hacking up some mucous,. If so, could I contribute a removed saliva gland to my friend for transplantation, so he can have some saliva again ? Will removing one or some saliva glands lessen my post nasal drip ?
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Hello Tim and welcome to the CSN H&N forum. I am sorry you have had to deal with issues surrounding this situation since shortly after birth. But I would say you are also amazingly Blessed to be in a place where something like that could be done in 1950, it sounds like quite a medical feat. I can commiserate with you on the allergy as I seem to have my share of sinus problems and an occasional infection.
To the best of my knowledge, I think they can remove saliva glands if necessary. Will it help your situation, I don’t know. As far as transplanting a saliva gland from one person to another I have never heard of it. Also between two people, there would be the possibility of rejection which would need to be addressed if this is possible at all. As far as being able to do anything to mitigate dry mouth and damaged saliva glands after H&N radiation or any medical procedures there is nothing that can be done at this point, I wish there was. I do know some people in our local H&N support group have had acupuncture and other things they have tried to mitigate this condition with mixed results. Some got relief to some extent and others noticed no difference, you just have to give things a try and sometimes you end up with positive results.
I found this in an article from 2020--Trends in Molecular Medicene
The vast majority of the 550,000 patients who undergo head and neck cancer radiotherapy annually and more than 4 million patients with Sjögren’s syndrome worldwide live with salivary gland dysfunction.
- There currently exists no U.S. Food and Drug Administration–approved permanent solution to salivary gland hypofunction and resulting xerostomia.
- Stem cell transplant to replace functional salivary gland tissue is an attractive therapeutic option.
- Advances in gene therapy have resulted in a number of studies investigating the replacement of key glandular components as a regenerative strategy.
- However, there still exists a clinical bottleneck, with the majority of products or strategies failing to reach phase 4.
Permanent damage to the salivary glands and resulting hyposalivation and xerostomia have a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients rely on lifelong treatments that alleviate the symptoms, but no long-term restorative solutions exist. Recent advances in adult stem cell enrichment and transplantation, bioengineering, and gene transfer have proved successful in rescuing salivary gland function in a number of animal models that reflect human diseases and that result in hyposalivation and xerostomia. By overcoming the limitations of stem cell transplants and better understanding the mechanisms of cellular plasticity in the adult salivary gland, such studies provide encouraging evidence that a regenerative strategy for patients will be available in the near future.
You can search "salivary gland transplant" and there is info there about doing some kind of transplant for severe dry eye involving minor salivary gland transplantation for severe dry eye but it is not yet viable for dry mouth.
I think if you want to pursue this you will need to start with a skilled ENT or a large hospital, or a teaching hospital to see if any or all of this is viable yet.
In the meantime here is an article from cancer.net on dealing with dry mouth.
And lastly Tim I wish you the best on alleviating your problem, I hope you can find a solution.
And if you find I am incorrect on any of this or find some good information on your searching please let us know.
Take care, God Bless-Russ
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