Gallbladder Cancer Info
Here is some info from an email response I just received in regards to a question I submitted to the Nagourney Cancer Institute regarding their current research and treatment for gallbladder cancer. This may be redundant for some but thought I'd share it anyway in case it is helpful for others:
Cholangiocarcinoma is quite common in Asia and rising in incidence in the western world. It is broken down into intrahepatic and extra hepatic.
Treatment with Cisplatin + Gemcitabine has provided meaningful benefit.
The biology of this disease is under investigation.
Among the gene aberrancies are kRas, P53, SMAD4.
More interesting is the finding of IDH1/2 mutations.
Our laboratory examines patients with this diagnosis to assess the role of cytotoxic chemotherapies, like the taxanes (Abraxane), antimetabolites (like Gemcitabine, 5FU) and others.
We are also extremely interested in signal transduction inhibitors that target IDH, SMAD, EGFR, FGFR, cMET, BCL2 and many others.
Our platform uses fresh biopsy material to isolate cellular aggregates (organoids) from the tumor and then conducts studies to measure drug induced cell death, synergy analyses and novel drug combinations.
To proceed we would require a biopsy specimen of about 1 cm3 (1 gram) in size. In addition ascites fluid can sometime be used for patients accumulating abdominal fluid.
Tissue must be fresh, sterile and transported to us by overnight courier. Some patients choose to travel to California to have the biopsy conducted by our surgeons.
If you would like to consider this approach, we can review the Ct’s to determine whether it can be easily done.
Robert Nagourney, MD
Medical and Laboratory Director
Nagourney Cancer Institute &
Associate Clinical Professor
University of California, Irvine
Office 562 989 6455
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