New drug combo for uterine serous carcinoma

Tamlen
Tamlen Member Posts: 343 Member
in Uterine/Endometrial Cancer #1

I came across this today, thought some of you might be interested:

New drug combo improves survival of women with rare uterine cancer

Comments

  • Northwoodsgirl
    Northwoodsgirl Member Posts: 571
    #2
    New drug serous uterine cancer
    Very interesting Phase 2 clinical trial results! Thank you for posting. Every day of extended survival helps to get us closer to a cure or prevention!
    Lori
  • Abbycat2
    Abbycat2 Member Posts: 644 Member
    #3
    Finally, a study that shows the benefit

    of Herceptin in the treatment of UPSC. I have been reading about women with UPSC who test positive for HER2/neu. A relative of mine had Her2/neu breast cancer- an aggressive form- so I read a lot about it and learned about the targeted therapy called Herceptin. Herceptin is given intravenously but is not considered to be chemotherapy. It's good to see research on this rare cancer. Thanks for sharing.

  • EZLiving66
    EZLiving66 Member Posts: 1,483 Member
    #4
    Love to hear this good news

    Love to hear this good news as being Stage II, UPSC, doesn't seem to get much notice in medical research.

    Thank you!!

    Love,

    Eldri

  • evolo58
    evolo58 Member Posts: 293 Member
    #5
    I don't have HER-2 (I

    I don't have HER2, according to my genetic testing results (I continue to be a real outlier in a real odd cancer ... great), but this could be encouraging for so many women.

    What puzzles me, though, is that the DFR (I've heard different periods of time, by the way, from different sources ... some up to a year to a year and a half), is so slight with this additional treatment. If it provided, perhaps, another two or three years, my ears would really perk up. Even an extra year. But it's only a few months. 

    This is proof we really need to know so much more about the Type 2s in general. So much more.

  • LisaPizza
    LisaPizza Member Posts: 358 Member
    #6
    evolo58 said:

    I don't have HER-2 (I

    I don't have HER2, according to my genetic testing results (I continue to be a real outlier in a real odd cancer ... great), but this could be encouraging for so many women.

    What puzzles me, though, is that the DFR (I've heard different periods of time, by the way, from different sources ... some up to a year to a year and a half), is so slight with this additional treatment. If it provided, perhaps, another two or three years, my ears would really perk up. Even an extra year. But it's only a few months. 

    This is proof we really need to know so much more about the Type 2s in general. So much more.

    I haven't read the details,

    I haven't read the details, but the average can be misleading. I assume it includes people who didn't respond at all, and people who had much longer lasting responses. Not expected to be a cure, it adds to the options. I wonder if given after a surgery and other treatments intended to cure, say stage 2 or 3, if it increases the percentage who never relapse.

  • Donna Faye
    Donna Faye Member Posts: 427 Member
    #7
    Interesting

    My gyn onc is one of the doctors on this trial. Interesting read.

  • Kindellano
    Kindellano Member Posts: 2
    edited October 2018 #8
    1st post here. Diagnosed 4

    1st post here. Diagnosed 4/2014 

    My Patti is in the middle of a recurrence of this UPSC, and we're told this next round of chemo will also have the HER2/Neu Herceptin suppressor. Hoping for good results. 

    Curious if anyone has tried alternative efforts. We're juicing, and looking into PEMF and ozone therapy. If anyone has any experience with these adjunctive options, please let us know. 

    Thanks

  • NoTimeForCancer
    NoTimeForCancer Member Posts: 3,486 Member
    #9
    Kindellano, I am so sorry to

    Kindellano, I am so sorry to hear about your Patti.  I cannot answer your question, but suspect some of the other wonderful ladies will be along.  Please let Patti know she is not alone and come back to tell us how she is doing.  

  • zsazsa1
    zsazsa1 Member Posts: 568 Member
    edited October 2018 #10
    The updated NCCN guidelines

    The updated NCCN guidelines as of October 17, 2018 recommend testing for Her2/Neu, and if positive, herceptin.  I'm not getting help in this from Hartford Hospital, but I went down to Yale for a consult, and they are doing the testing.  If my tumor has Her2/Neu, I will then have to fight the insurer to cover herceptin.

    Interestingly, a new study just came out that showed that herceptin seemed to have been of benefit in triple negative breast cancer, even if the Her2/Neu receptor was NOT present.

    Kindellano, the researcher at Yale said that he has seen good responses to herceptin in UPSC.

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