PALB2, variant p.Y1183

alandebby
alandebby Member Posts: 2 Member
edited September 2017 in Ovarian Cancer #1

I was diagnoised with stage III Ovarian cancer in October of 2013.  Surgery and chemotherapy afterwards.  In January of 2014, I was informed that I had the PALB2 gene mutaiton.  This gene mutation partners with the BRCA 2 gene mutation and therby increases risk of breast, pancreatic, colon and ovarian cancers.  

My geneticist , who specializes in this gene mutation, has encouraged me to try to find others who have this same gene mutation with the same variant (p.Y1183) because chances are we are related.  If we can find the common family history line of orgin, we might possibly be albe to then move forward and be able to warn others in the family line of their possible risk of the gene mutation.

 

I've been blessed thus far to continue to be a previvor,  but it would be so great to be able to inform others of their possible risk.  If anyone has suggestions as to how to go about this, I would appreciate input.

Comments

  • KCFirefly
    KCFirefly Member Posts: 1
    edited November 2017 #2
    I also have the PALB2 mutation

    I was diagnosed with Stage 1A mucinous adenocarcinoma in February 2017 after a unilateral salpingo oopherectomy. I then had a laprscopic hysterectomy and omentectomy along with removal of lymph nodes and a few months of chemo (carbo/taxol). I finished chemo in August. I'm on Youtube if you want the details, as Anxiety Girl.

  • thebes219
    thebes219 Member Posts: 1
    #3
    I have the same variant

    I was diagnosed with stage 3 breast cancer in 2011. I discovered I had the palb2 mutation (Y1183 variant) a couple of years ago and I just found your post while doing a google search. Both sides of my family had a history of BC so I'm not certain from which parent I inherited the mutation. I also have been doing genealogy for some time so I would be interested to discover if we are indeed related. Please feel free to send me a PM. Thanks, Karen

     

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