Metformin question

takingcontrol58

Red Dahlia said:

Hello Takingcontrol58,

I looked up my report and it says Endometrial Cancer panel. It says the genes evaluated were BRCA1, BRCA2, CHEK2, EPCAM, MLH1, MLH2, MSH2, MSH6, MUTYH, PMS2, POLD1, PTEN, TP53.  

All were reported as negative.  These do not to seem to correlate with what you were tested for. Thanks for the info. On insulin growth factor

Full Genomic Panel from Foundation One

Red Dahlia,
I looked up all the genes you had evaluated- they are all included in the Foundation One profile (except I didn't see MLH2).
Mine were all negative as well.

My test was done in February 2015- they update the panel periodically.  You weren't tested for many of the genes tied to
endometrial cancer. BRCA1 and BRCA2 is more is breast and ovarian cancer. MSH2, MSH6, PMS2, MLH1 (Lynch Syndrome)
PTEN and TP53 are tied to endometrial cancer.  But endometrial cancer has more frequent mutations in the PI3K/AKT/Mtor pathway than
any other tumor type studied by The Cancer Genome Atlas (TCGA). According to my Foundation One genomic test, 21-43% of endometrioid
tumors have a mutation on this pathway.

As I mentioned, the Foundation One panel tests for over 315 mutations.  You need to be tested for many more gene mutations to
figure out what may be mutated. It is odd that they only tested you for a few genes that are relevant to endometrial cancer.

A great article to read to become familiar with all the genes tied to endometrial cancer is at www.pubmed.gov- called
"Integrated genomic characterization of endometrial carcinoma", from Nature Magazine August 2013. I don't have the pub med
number but hopefully you can find it by the title. Let me know if you can't find the article.

I also had two other gene mutations- RB1, and SF3B1.  I give them to you so you can see if they show up when you get your genomic
analysis. I had four gene mutations in total.

This is all like solving a mystery.  Good luck with your gene testing.

Takingcontrol58