Anyone have sister or sisters that are BRCA positive if you are negative (or vice versa)??

Vickierph

I was diagnosed in 1/2013 w/stage 1c OC. My mother's family - at least the one's I know of have a big history of Breast Cancer - 2 of her sisters died young 37 and 50 years old -- the one that was 37 died back in the early 1970s, the other one in the early 1990s. I also have 2 cousins who are sisters (their dad is my mom's brother) also had breast cancer in their late 40's early 50's --and both are doing well. They have not been tested for BRCA .  I was BRCA negative, much to my surprise. My younger sister is facing a possible breast cancer diagnosis -- she is having a needle biopsy of some calcifications on Tuesday and has been warned by a radiologist it has a good chance of being negative. Is there a chance she could be BRCA positive, even if I am not? She has 2 daughters, so this could be something she needs to find out. Thanks for any input. Vickie

Alexandra

Hello Vickie

If one of your parents was BRCA positive, it is possible that your sister could be BRCA+ even if you are BRCA-. It is hard to tell without testing.

In my case my father is deceased, my mother tested BRCA negative. I tested BRCA 1 positive (so my gene came from paternal side).

My only daughter had 50% chance of inheriting my gene mutation, but she tested BRCA negative.