What's Coming Down the Pike
Hello Ladies..! OK, I have been reading around here for a while. But I did not find a thread of this type. Over in the Kidney secition one of our brainiacs started a thread with the above name. This has all the latest and greatest new treatments in Clinical Trials. Also for those that may not be aware there is this WEB site, check out AACR. AACR has multiple conference and for those interested in gaining in depth knowledge may be a great resource. Also note that as a patient / advocate you can join for free..!
If you do a clinical trials search under Ovarian, there are 505 entries..! I know there are some exciting new treatments out there... some have not yet started the first human testing. One of them is CD47.
I mention CD47, because this could be the "silver bullet" for many types of Cancer... So this is just one of many possibilities to watch. Here is a link to some CD 47 info.. http://stemcell.stanford.edu/CD47/
Being I am being treated at Stanford, I have already raised my hand as a possible "lab rat" on CD47.
I hope this is of help to all of you...
Be Well All..!!
Ron
Comments
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Thanks Ron! I'm not
Thanks Ron! I'm not ovarian{Uterine}, but I would volunteer for "lab-rat" status in a heart beat! God forbid I ever reacure, but I saved the link you sent to my favorites. Keep on the lookout for my particular bad boy, UPSC, cancer trial! Best, Debrajo
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Hi Ron
Cousin Susan here (just so you can recognize my screen name) Thanks for your amazing love and support. I am lucky to have you in my circle of friends, doubly lucky to be related. I am researching clinical trials whenever my brain is clear enough to plow through them. Warm hugs.
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Thanks
Thanks for riding over to post on this board to tell us what's coming down the pike!
Much appreciated!!
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OH NO..!! I am busted bigscantillon said:Hi Ron
Cousin Susan here (just so you can recognize my screen name) Thanks for your amazing love and support. I am lucky to have you in my circle of friends, doubly lucky to be related. I am researching clinical trials whenever my brain is clear enough to plow through them. Warm hugs.
OH NO..!! I am busted big time now..!! Nice self portrait..! I really like the hair do.... heh...
Ron
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Time2timothy1 7 said:Thanks
Thanks for riding over to post on this board to tell us what's coming down the pike!
Much appreciated!!
Guess it is time for me to put some.. "meat and potatoes" here... although some or all may not be new, this is one of many on going articles...
http://www.cancer.org/cancer/ovariancancer/overviewguide/ovarian-cancer-overview-new-research
Mentions Avastin and Votrient. Both have had some success with other types of Cancer. I was on Votrient and it worked great...althought it was not Liver friendly for me. Yes it may not be Liver friendly for everyone..
Not as recent.. but.. http://www.ncbi.nlm.nih.gov/pubmed/21913063
More info... http://www.ovariancancer.org/report-from-asco-2013-new-research-on-ovarian-cancer/ Pazopanib = Votrient
Here is a good link... lots of info.. includes results from some Clinical Trials http://www.cancer.gov/search/results
I will add my 2 cents worth on Votrient. This is a pill that comes mostly in 200 MG dose. Max dose is 800 mg taken daily. Stability can happen in levels down to 200 MG. Side effects vary.. most common are Fatigue, diarrhea, hypertension, elevated Liver enzymes, weight loss, WHITE hair (no hair loss), some nausea, a few others. I had nasuea for only a few minutes for the first two days.. almost nothing. I did lose 14 pounds the first month. But you need regular blood work, as elevated Liver enzymes is noticed.. I started at max dose of 800 MG, and then reduced to 600 MG, Liver enzymes got acceptable on the lower dose, but my Bilirubin shot up so had to leave the (working) Votrient.
However, I can only wonder... if Votrient works for some Ovarian Cancers, than perhaps some other targeted drugs may work as well..??? Hope there are some Clinical Trials going on to prove / disprove that..!
Be Well All..!!
Ron - "I don't want a pickle.. jus wanna ride my motor sickle.."
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Welcome Cousin Susan!
Ron's been talking about his beloved Michigan cousin for so long. It's good to finally put a face to the name, even if it's a drawing
Come back often and feel better!
Ron - you are a fountain of knowledge, even more so since you're retired.
Luv,
Alexandra
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THANK YOU, RON & WELCOME SUSAN!scantillon said:Hi Ron
Cousin Susan here (just so you can recognize my screen name) Thanks for your amazing love and support. I am lucky to have you in my circle of friends, doubly lucky to be related. I am researching clinical trials whenever my brain is clear enough to plow through them. Warm hugs.
Thank you for all the info, Ron. My radiation oncologist just attended a meeting about something coming up for breast cancer. She couldn't say what, but said it sounds promising.
Welcome, Susan! I'm in Michigan, too! Just a small bio on me: OVCA in 2000 and a recurrance in 2006. Breast cancer dx in October 2013 - currently undergoing radiation.
I wish you both well, and hope that you'll visit often. We're a great group here!
Prayers & (((HUGS)))
Monika0 -
Thanks so much for postingAlexandra said:Welcome Cousin Susan!
Ron's been talking about his beloved Michigan cousin for so long. It's good to finally put a face to the name, even if it's a drawing
Come back often and feel better!
Ron - you are a fountain of knowledge, even more so since you're retired.
Luv,
Alexandra
Thanks so much for posting this. GREAT info!
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Thank you, RonDee5678 said:Thanks so much for posting
Thanks so much for posting this. GREAT info!
Thank you for taking care of us ladies! And welcome Susan! Ron, I admire your motor sickle and Susan, I think your picture is very cute!
Kelly
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OK, kind of related. Inlovesanimals said:Thank you, Ron
Thank you for taking care of us ladies! And welcome Susan! Ron, I admire your motor sickle and Susan, I think your picture is very cute!
Kelly
OK, kind of related. In April I will be attending an annual Cancer conference in San Diego. This conference is from AACR - American Association for Cancer Research.. I am going as a Patient / Advocate, which means I have to make a large poster and presentation. But this conference will have the smartest researchers from all over... tell us all the latest and greatest findings. I hope to make many of the special presentations and also try to take good notes. If I learn of anything juicy for O.C, I will post it here.
http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx <=link to the conference info.
http://www.aacr.org/home/survivors--advocates.aspx
Oh yes, thanks ladies for the kind words...! Try and smile at least once a day... I do..!
Be Well All..!!!
Ron
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PD-1 / PDl-1GSRon said:OK, kind of related. In
OK, kind of related. In April I will be attending an annual Cancer conference in San Diego. This conference is from AACR - American Association for Cancer Research.. I am going as a Patient / Advocate, which means I have to make a large poster and presentation. But this conference will have the smartest researchers from all over... tell us all the latest and greatest findings. I hope to make many of the special presentations and also try to take good notes. If I learn of anything juicy for O.C, I will post it here.
http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx <=link to the conference info.
http://www.aacr.org/home/survivors--advocates.aspx
Oh yes, thanks ladies for the kind words...! Try and smile at least once a day... I do..!
Be Well All..!!!
Ron
Hey ladies... not sure if you are aware but.. one of the new buzz words are Immune-Checkpoint Inhibitors. All kinds of stuff about PD-1 and PDL-1 treatments. So far some good news on Lung Cancer.. but there are some trials that include O.C. patients.. Here is the latest scoop I found..
This one is already dated 2012, but is worth reading..
http://clincancerres.aacrjournals.org/content/19/6/1363
PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction
Here is another interesting link
http://annonc.oxfordjournals.org/content/early/2013/11/26/annonc.mdt405.abstract
And one more...
http://www.ncbi.nlm.nih.gov/pubmed/23975756
Tired now.. later
Ron
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Well.. This is not my normalGSRon said:PD-1 / PDl-1
Hey ladies... not sure if you are aware but.. one of the new buzz words are Immune-Checkpoint Inhibitors. All kinds of stuff about PD-1 and PDL-1 treatments. So far some good news on Lung Cancer.. but there are some trials that include O.C. patients.. Here is the latest scoop I found..
This one is already dated 2012, but is worth reading..
http://clincancerres.aacrjournals.org/content/19/6/1363
PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction
Here is another interesting link
http://annonc.oxfordjournals.org/content/early/2013/11/26/annonc.mdt405.abstract
And one more...
http://www.ncbi.nlm.nih.gov/pubmed/23975756
Tired now.. later
Ron
Well.. This is not my normal happy story, but if I can help someone... I have to try. I did not want to start a new thread... but there is one issue I (we.?) need to be aware of, and not fall prey to... the scammers. Now there is no one that has any kind of Cancer that does not want to be cured.. we all do..! But I feel strongly to be aware of those just trying to take our money and possibly cause harm along the way. We are easy prey, after all. We used to hear of con artists taking little old ladies hard earned savings... yes.. there are false Cancer cures. Some do nothing, some are very harmful, and some reduce our life clock's time. This is what can be good about a forum like this...
So, yesterday, I met my new lawyer.. (old case started before I heard those 3 words..). I told him this needs to be settled.. and gave him just a bit of my story. Well, he responded with a story of his own... his Uncle.. This Uncle went down to Mexico for treatment. No arguement, the guy was told it was too late, his Cancer was wide spread and an aggressive type. So, yes I can see getting desperite, as would any of us. But here was a couple in retirment, house paid for, etc.. He goes down to one of those "Clinics", they bilk him for everything... and yet he dies in the same time frame he was told before. Sad, very sad.. well his wife now has nothing... zero.. the house was mortgaged to pay for the treatments, all the savings gone... There is nothing good about this type of scenario..
Here is a link worth reading... I think it is dated, but will give you the idea. As much as we want new drugs approved ASAP, the FDA process is meant to protect us... yes sometimes it fails..! There are some new treatments soon to begin human trials... hope we all hang on to see a "cure" one day.. I pray for that..!
Oh, I must also state that yes I have tried two of the supposed cures... a dear friend urged me to do it.. he was sure it would cure me. I love him for his care and efforts.. sadly he died on Valentines Day... sigh..
http://www.quackwatch.org/01QuackeryRelatedTopics/cancer.html
Another article, but it is from 2000 http://www.ncahf.org/articles/c-d/caquackery.html Actually here is the link to more current articles.
http://www.ncahf.org/index.html
NOTE: I am not endorsing these articles, I am just providing the links for you to decide what is best for you and provide some awareness. Again we are all different and must make our own decisions.
Ron
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Thanks, Ron!GSRon said:Well.. This is not my normal
Well.. This is not my normal happy story, but if I can help someone... I have to try. I did not want to start a new thread... but there is one issue I (we.?) need to be aware of, and not fall prey to... the scammers. Now there is no one that has any kind of Cancer that does not want to be cured.. we all do..! But I feel strongly to be aware of those just trying to take our money and possibly cause harm along the way. We are easy prey, after all. We used to hear of con artists taking little old ladies hard earned savings... yes.. there are false Cancer cures. Some do nothing, some are very harmful, and some reduce our life clock's time. This is what can be good about a forum like this...
So, yesterday, I met my new lawyer.. (old case started before I heard those 3 words..). I told him this needs to be settled.. and gave him just a bit of my story. Well, he responded with a story of his own... his Uncle.. This Uncle went down to Mexico for treatment. No arguement, the guy was told it was too late, his Cancer was wide spread and an aggressive type. So, yes I can see getting desperite, as would any of us. But here was a couple in retirment, house paid for, etc.. He goes down to one of those "Clinics", they bilk him for everything... and yet he dies in the same time frame he was told before. Sad, very sad.. well his wife now has nothing... zero.. the house was mortgaged to pay for the treatments, all the savings gone... There is nothing good about this type of scenario..
Here is a link worth reading... I think it is dated, but will give you the idea. As much as we want new drugs approved ASAP, the FDA process is meant to protect us... yes sometimes it fails..! There are some new treatments soon to begin human trials... hope we all hang on to see a "cure" one day.. I pray for that..!
Oh, I must also state that yes I have tried two of the supposed cures... a dear friend urged me to do it.. he was sure it would cure me. I love him for his care and efforts.. sadly he died on Valentines Day... sigh..
http://www.quackwatch.org/01QuackeryRelatedTopics/cancer.html
Another article, but it is from 2000 http://www.ncahf.org/articles/c-d/caquackery.html Actually here is the link to more current articles.
http://www.ncahf.org/index.html
NOTE: I am not endorsing these articles, I am just providing the links for you to decide what is best for you and provide some awareness. Again we are all different and must make our own decisions.
Ron
We cannot be told often enough to be aware of the scammers and quacks who take advantage of people desperate for hope and a cure.
Praying for a real cure,
Kelly
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New Triallovesanimals said:Thanks, Ron!
We cannot be told often enough to be aware of the scammers and quacks who take advantage of people desperate for hope and a cure.
Praying for a real cure,
Kelly
Hi All..!! I hope all you ladies are properly misbehaving..! Figured I would pass this one on.. a Clinical Trail combining Anti PD-1 and another drug. For those new to the Anti PD-1 and Anti PD-L1 (often the "Anti" is left off to type less... heh). These are fairly new treatments in clinical trials mostly for other Cancers. But this trial is including Ovarian patients, which is why I posted it here. Hopefully none of you are candidates.. but if you are, hope you get a spot. A pal of mine just had his first Anti PD-L1 infusion a few days ago. It took about an hour, and the only real side effect was a fever. Fever is an expected side effect, and some think it is a sign it is working. These new drugs have had some good results so far... so stay tuned..!
https://www.smartpatients.com/trials/NCT01714739
Another one of my "watch list" treatments is CD47. This treatment has not yet started human testing, but hopefully starts this year.. CD47 is a protein that tells our immune system "don't eat me." The treatment unmasks the Cancer cells and lets our immune system slay the little dragon Bas****s. This has had a huge success in mice.. hope we are mice like enough..
Stay Well All..!!!
Ron
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Diet....GSRon said:New Trial
Hi All..!! I hope all you ladies are properly misbehaving..! Figured I would pass this one on.. a Clinical Trail combining Anti PD-1 and another drug. For those new to the Anti PD-1 and Anti PD-L1 (often the "Anti" is left off to type less... heh). These are fairly new treatments in clinical trials mostly for other Cancers. But this trial is including Ovarian patients, which is why I posted it here. Hopefully none of you are candidates.. but if you are, hope you get a spot. A pal of mine just had his first Anti PD-L1 infusion a few days ago. It took about an hour, and the only real side effect was a fever. Fever is an expected side effect, and some think it is a sign it is working. These new drugs have had some good results so far... so stay tuned..!
https://www.smartpatients.com/trials/NCT01714739
Another one of my "watch list" treatments is CD47. This treatment has not yet started human testing, but hopefully starts this year.. CD47 is a protein that tells our immune system "don't eat me." The treatment unmasks the Cancer cells and lets our immune system slay the little dragon Bas****s. This has had a huge success in mice.. hope we are mice like enough..
Stay Well All..!!!
Ron
Already olde but still has a lot of good info... Yes many of us cringe when we hear the word diet... well this video is different.. instead of telling you what not to eat.. this says what we should eat... I had changed my diet to include more of these foods, 2 years ago now... Some of the drugs mentioned were new and some were not FDA approved at that time... and the whole science is light years ahead today... just 4 years later...
http://www.ted.com/talks/william_li#t-765323
Ron
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AACRGSRon said:Diet....
Already olde but still has a lot of good info... Yes many of us cringe when we hear the word diet... well this video is different.. instead of telling you what not to eat.. this says what we should eat... I had changed my diet to include more of these foods, 2 years ago now... Some of the drugs mentioned were new and some were not FDA approved at that time... and the whole science is light years ahead today... just 4 years later...
http://www.ted.com/talks/william_li#t-765323
Ron
Hi Ladies... OK, I am at the annual AACR Conference. (American Association for Cancer Research). This is a huge conference about 28,000 people are here. And a bunch of the brainiacs in Cancer Research..! There are sessions on most types of Cancer and most of the latest treatments, plus those in or soon to be in clinical trials. There are multiple sessions during each time slot, so no way can one person see them all. BUT, I am scheduled to make a bunch of sessions that cross over to many types of Cancer.
So, here is the deal... if you have any questions, let me have them. I can not promise to get them all answered, but I will try.
Today I was sitting next to one of those brainiacs from UofMinnesota. This guy is a researcher as well as a doctor, etc. I mentioned that some drugs for one type of Cancer are now (finally) being tested for other types. He smiled and said yes there is some value and perhaps additional treatments possible. BUT, this year's buzz words related to Biomarkers. Most of you (maybe all) are all too familiar with markers like CA125. But that is just the tip of the ole iceberg. It is thought that by identifying more Biomarkers, Doctor's will KNOW what treatments will not work and which ones should work. This can be huge, as we all know taking a nasty drug that won't help you is of no value, while having the knowledge that the drug you will take is very likely to help you yields better results. Additionally, this can lead to more treatments based on the markers. Now a lot of this is over my head, but I understand getting the right treatment is a good thing..!
I must say it was humbling to sit with people that have had multiple Cancers and multiple reoccurances. But I must tell you I heard the story of a 19 year Ovarian survivor.
Be Well All..!!
Ron
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Ron,GSRon said:AACR
Hi Ladies... OK, I am at the annual AACR Conference. (American Association for Cancer Research). This is a huge conference about 28,000 people are here. And a bunch of the brainiacs in Cancer Research..! There are sessions on most types of Cancer and most of the latest treatments, plus those in or soon to be in clinical trials. There are multiple sessions during each time slot, so no way can one person see them all. BUT, I am scheduled to make a bunch of sessions that cross over to many types of Cancer.
So, here is the deal... if you have any questions, let me have them. I can not promise to get them all answered, but I will try.
Today I was sitting next to one of those brainiacs from UofMinnesota. This guy is a researcher as well as a doctor, etc. I mentioned that some drugs for one type of Cancer are now (finally) being tested for other types. He smiled and said yes there is some value and perhaps additional treatments possible. BUT, this year's buzz words related to Biomarkers. Most of you (maybe all) are all too familiar with markers like CA125. But that is just the tip of the ole iceberg. It is thought that by identifying more Biomarkers, Doctor's will KNOW what treatments will not work and which ones should work. This can be huge, as we all know taking a nasty drug that won't help you is of no value, while having the knowledge that the drug you will take is very likely to help you yields better results. Additionally, this can lead to more treatments based on the markers. Now a lot of this is over my head, but I understand getting the right treatment is a good thing..!
I must say it was humbling to sit with people that have had multiple Cancers and multiple reoccurances. But I must tell you I heard the story of a 19 year Ovarian survivor.
Be Well All..!!
Ron
Thank you for the linksRon,
Thank you for the links and all the information. I can only imagine what it is like to be at the conference. Look forward to hearing more.
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GoshGSRon said:AACR
Hi Ladies... OK, I am at the annual AACR Conference. (American Association for Cancer Research). This is a huge conference about 28,000 people are here. And a bunch of the brainiacs in Cancer Research..! There are sessions on most types of Cancer and most of the latest treatments, plus those in or soon to be in clinical trials. There are multiple sessions during each time slot, so no way can one person see them all. BUT, I am scheduled to make a bunch of sessions that cross over to many types of Cancer.
So, here is the deal... if you have any questions, let me have them. I can not promise to get them all answered, but I will try.
Today I was sitting next to one of those brainiacs from UofMinnesota. This guy is a researcher as well as a doctor, etc. I mentioned that some drugs for one type of Cancer are now (finally) being tested for other types. He smiled and said yes there is some value and perhaps additional treatments possible. BUT, this year's buzz words related to Biomarkers. Most of you (maybe all) are all too familiar with markers like CA125. But that is just the tip of the ole iceberg. It is thought that by identifying more Biomarkers, Doctor's will KNOW what treatments will not work and which ones should work. This can be huge, as we all know taking a nasty drug that won't help you is of no value, while having the knowledge that the drug you will take is very likely to help you yields better results. Additionally, this can lead to more treatments based on the markers. Now a lot of this is over my head, but I understand getting the right treatment is a good thing..!
I must say it was humbling to sit with people that have had multiple Cancers and multiple reoccurances. But I must tell you I heard the story of a 19 year Ovarian survivor.
Be Well All..!!
Ron
I don't have anything specific to ask but look forward to having you share whatever you learn. Take good notes!
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Thank you brotherGSRon said:AACR
Hi Ladies... OK, I am at the annual AACR Conference. (American Association for Cancer Research). This is a huge conference about 28,000 people are here. And a bunch of the brainiacs in Cancer Research..! There are sessions on most types of Cancer and most of the latest treatments, plus those in or soon to be in clinical trials. There are multiple sessions during each time slot, so no way can one person see them all. BUT, I am scheduled to make a bunch of sessions that cross over to many types of Cancer.
So, here is the deal... if you have any questions, let me have them. I can not promise to get them all answered, but I will try.
Today I was sitting next to one of those brainiacs from UofMinnesota. This guy is a researcher as well as a doctor, etc. I mentioned that some drugs for one type of Cancer are now (finally) being tested for other types. He smiled and said yes there is some value and perhaps additional treatments possible. BUT, this year's buzz words related to Biomarkers. Most of you (maybe all) are all too familiar with markers like CA125. But that is just the tip of the ole iceberg. It is thought that by identifying more Biomarkers, Doctor's will KNOW what treatments will not work and which ones should work. This can be huge, as we all know taking a nasty drug that won't help you is of no value, while having the knowledge that the drug you will take is very likely to help you yields better results. Additionally, this can lead to more treatments based on the markers. Now a lot of this is over my head, but I understand getting the right treatment is a good thing..!
I must say it was humbling to sit with people that have had multiple Cancers and multiple reoccurances. But I must tell you I heard the story of a 19 year Ovarian survivor.
Be Well All..!!
Ron
Ron you are nominated Honorary Chair of the ovarian board (sans ovaries). Whatever info you can get at the conference is greatly appreciated.
I am curious why Stanford anti-CD47 trial has been pushed back again http://stemcell.stanford.edu/CD47/
Are any of the 5 new PARP inhibitors close to being submitted for FDA approval?
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Ok, sorry, I have been slowAlexandra said:Thank you brother
Ron you are nominated Honorary Chair of the ovarian board (sans ovaries). Whatever info you can get at the conference is greatly appreciated.
I am curious why Stanford anti-CD47 trial has been pushed back again http://stemcell.stanford.edu/CD47/
Are any of the 5 new PARP inhibitors close to being submitted for FDA approval?
Ok, sorry, I have been slow to update here.. The conference was amazing.. And just so you all know, any of you could apply to attend next year. Next year the conference will be in Philly, Pa. Applications will be out later this year. However, if you get accepted as a patient/advocate they will work you..! But it is very educational and you will be on top of the latest Cancer happenings. So, there is a lot happening in the Cancer world, yes including Ovc. Lots more clinical trials with both current and future treatments.
Yes CD47 git pushed back... not sure why. I will be at Stanford next week and will try to find out. The session that Dr Weissmann gave had us all wide eyed. And the Anti PD-1 and PD-L1 are in trials already and have had some amazing results. Less side effects, better efficacy, a lot to like..! So this is where I suggest you ladies stay dilligent and watch out for clinical trials that you may be eligible for. I will post the link to the CD47 session... yes a lot of words that we won't understand, but then there will be a lot you will understand. It is 30 minutes and I think you will like this doctor.. Plus there are a bunch of WEB casts for viewing. More to follow...
Here is the one video link.. http://webcast.aacr.org/console/player/23028?mediaType=podiumVideo&
Ron
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