Second opinion? How do you know when you should seek one?

seatown

Got the results from my latest CT scan last week.  Long story short, it shows “something” on my spleen. My gyn/onc surgeon thinks it may be a recurrence of my primary peritoneal cancer. My CA-125 number has been slowly rising since summer & is now 44. The surgeon presented several options but recommended a 90-day period of “benign neglect” with no monitoring during that time, but with the addition of the oral drug Arimidex. Have already been on Carboplatin/Taxol in 2012 with good results. Then last year, after positive biopsies, had Carbo/Taxol again with the addition of Avastin (which apparently didn't work for me). I chose the recommended new option but worry that I should seek more aggressive treatment. Reading the literature about recurrences scares me, although I know many people are in far worse situations. Been thinking about seeking an appointment with a leading figure in gynecological cancers—not that my present docs aren’t highly regarded. How do you decide what to do?