The Cancer Survivors Network (CSN) is a peer support community for cancer patients, survivors, caregivers, families, and friends! CSN is a safe place to connect with others who share your interests and experiences.

Thank you for being a part of the Cancer Survivor Network community. Survivors and caregivers like you have played a unique role in fostering an online environment that encourages connection among those needing support, community, and education. On May 28, the Network will be discontinued. More details are available here . If you have any questions, contact CSNSupportTeam@cancer.org. Thanks again for the support you’ve provided each other over the years. We remain committed to supporting you in other ways throughout your cancer journey.

Of interest to those who are NED with BRCA mutation

Alexandra
Alexandra CSN Member Posts: 1,308
in Ovarian Cancer #1

New trial NCT01847274, sponsored by Tesaro, Inc. not yet recruiting. 

A Maintenance Study With Niraparib Versus Placebo in Patients With Platinum Sensitive Ovarian Cancer

Niraparib, formerly known as MK-4827, is an orally active and potent poly (ADP-ribose) polymerase, or PARP inhibitor. A Phase 1/2 monotherapy study has been completed in more than 100 patients with advanced solid tumors. Based upon the results of the Phase 1/2 study and published data from other trials of PARP inhibitors, TESARO plans to further evaluate niraparib at a dose of 300 milligrams once daily in each of two Phase 3 studies as a maintenance therapy in patients with platinum sensitive ovarian cancer and in germline BRCA breast cancer.

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study of niraparib as maintenance in platinum sensitive ovarian cancer patients who have either gBRCAmut or a tumor with high-grade serous histology and who have responded to their most recent chemotherapy containing a platinum agent. Niraparib or placebo (in a 2:1 ratio) will be administered once daily continuously during a 28-day cycle.

 

I emailed Tesaro today and received reply within minutes. I'm waiting for the list of local investigators, which I will post here once available.

Like Care

Comments

  • lovesanimals
    lovesanimals CSN Member Posts: 1,366 Member
    #2
    Thanks for the information

    I do not know yet if I carry the BRCA mutation but I hope to find out soon after my August 1 meeting with a genetic counselor.

    Kelly

    Like Care

Discussion Boards