"Colorectal Cancer Treatments and Therapy Innovations"

coloCan

www.cancernetwork.com/colorectal-cancer/content/article/10165/2143619

according to Dr Leonard Saltz (see middle for comments on KRAS testing)

pete43lost_at_sea

always great steve

from the link

We thought we had something in terms of the BRAFmutation, but in fact the trial of the BRAF inhibitor vemurafenib by itself was ineffective in BRAF-mutated colorectal cancer. We are looking at strategies now that might augment that, and I hope that the combination or use of multiple targeted agents and rationally designed therapies for specific mutational profiles and identification of specific treatable subgroups is going to change the way we treat this disease. We will just have to see how that plays out over the next few years

 

if anyone is interested in braf antibody therapy get a quote from hallwang. It was proposed day1 of recurrence 2, but i checked and i am braf negative. this therapy does not appear to be in the us based on the article.

coloCan

pete43lost_at_sea said:

always great steve

from the link

We thought we had something in terms of the BRAFmutation, but in fact the trial of the BRAF inhibitor vemurafenib by itself was ineffective in BRAF-mutated colorectal cancer. We are looking at strategies now that might augment that, and I hope that the combination or use of multiple targeted agents and rationally designed therapies for specific mutational profiles and identification of specific treatable subgroups is going to change the way we treat this disease. We will just have to see how that plays out over the next few years

 

if anyone is interested in braf antibody therapy get a quote from hallwang. It was proposed day1 of recurrence 2, but i checked and i am braf negative. this therapy does not appear to be in the us based on the article.

We don't hear much on BRAF here;i'd read a study on

Vem......and have come across a number of items being investigated for BRAF (or PIK3/AKT or PTEN.)...Vemurafenib seemed to be effective in less than 10% of BRAF mutant CRCs

Something called Gabexate Mesilate  was being studied for KRAS,BRAF and PIK3CA mutations;another was  called CEP-32496,a BRAF(V600E)inhibitor

I just came across this article below on nano tech and hyperthermia

www.nanowerk.com/spotlight/spotid=30633.php

Hope  your treatment proves successful;keep fighting Pete

pete43lost_at_sea

coloCan said:

We don't hear much on BRAF here;i'd read a study on

Vem......and have come across a number of items being investigated for BRAF (or PIK3/AKT or PTEN.)...Vemurafenib seemed to be effective in less than 10% of BRAF mutant CRCs

Something called Gabexate Mesilate  was being studied for KRAS,BRAF and PIK3CA mutations;another was  called CEP-32496,a BRAF(V600E)inhibitor

I just came across this article below on nano tech and hyperthermia

www.nanowerk.com/spotlight/spotid=30633.php

Hope  your treatment proves successful;keep fighting Pete

THANKS STEVE

its not a common mutation for us crc's, thank god really, its a negative prognostic indicator, but tht could change if we have an effective way of targeting the braf mutation.

do you know that most of your great research ends up on my blog, the relevant stuff for me, or really interesting, which most of the research you share here is.

thanks again, if i make it, which I will, well it will be largely due to what I have learned here from many clever folks.

hugs,

Pete

tanstaafl

such faint, ineffective pharma criticism by MSKCC

I feel underwhelmed by this guy's criticism of 1.4 months here, and [$xxx,000] there by taking meaningul, competitive actions.

If MSKCC were such hot sh, er, stuff, they'd do  better than my wife with the adjuncts like cimetidine, metformin, celecoxib, aspirin, vit D3/K2/B6, PSK, etc being evaluated from Dx day 1, instead of waiting for others do it.