My husband started Afinitor 12 days ago after Votrient stopped working for him after 5 1/2 months. Well he is only 12 days in and he has a bad rash, severe back pain and his face and eyes are swollen and puffy. His Renal Oncologist took him off of Afinitor until at least next week when he goes back to Duke. I am curious if any of you that have been on Afinitor have had this happen? If so were you able to go back on it or did you have to switch to other treatment options? The triage nurse talked like he would not go back on it next week with this happening already. Oh he is also more fatique and staying in bed at least 15-16 hours a day.